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http://hdl.handle.net/1942/30356| Title: | Balancing benefits and risks in the era of biologics | Authors: | Adami, Giovanni Saag, Kenneth G. Chapurlat, Roland D. Guanabens, Nuria Haugeberg, Glenn Lems, Willem F. Matijevic, Radmila Peel, Nicola Poddubnyy, Denis GEUSENS, Piet |
Issue Date: | 2019 | Publisher: | SAGE PUBLICATIONS LTD | Source: | THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 11 (Art N° UNSP 1759720X19883973) | Abstract: | Biologics are substances synthetized from biological sources used in the prevention and treatment of several diseases. Rheumatologists have many years of experience with biologics for the treatment of immune-mediated diseases and osteoporosis. Randomized clinical trials and postmarketing studies have demonstrated that treatment with biologics can result, albeit infrequently, in serious adverse events. To date, several risk mitigation strategies have been identified and implemented. The objective of the present perspective review is to examine the risk mitigation strategies of biologic treatments, with special focus on anti-tumor necrosis factors and denosumab. | Notes: | Adami, G (reprint author), Univ Verona, Rheumatol Unit, Pz Scuro 10, I-37135 Verona, Italy. adami.g@yahoo.com |
Keywords: | benefit-risk ratio;biologics;denosumab;romosozumab | Document URI: | http://hdl.handle.net/1942/30356 | ISSN: | 1759-720X | e-ISSN: | 1759-7218 | DOI: | 10.1177/1759720X19883973 | ISI #: | WOS:000492881100001 | Rights: | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
| Appears in Collections: | Research publications |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 1759720x19883973.pdf | Published version | 187.25 kB | Adobe PDF | View/Open |
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