Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30370
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEven, Aviel-
dc.contributor.authorMORELLI, Giovanni-
dc.contributor.authorBroix, Loïc-
dc.contributor.authorScaramuzzino, Chiara-
dc.contributor.authorTurchetto, Silvia-
dc.contributor.authorGladwyn-Ng, Ivan-
dc.contributor.authorLe Bail, Romain-
dc.contributor.authorShilian, Michal-
dc.contributor.authorFreeman, Stephen-
dc.contributor.authorMagiera, Maria-
dc.contributor.authorJijumon, A-
dc.contributor.authorKrusy, Nathalie-
dc.contributor.authorMalgrange, Brigitte-
dc.contributor.authorBRONE, Bert-
dc.contributor.authorDietrich, Paula-
dc.contributor.authorDragatsis, Ioannis-
dc.contributor.authorJanke, Carsten-
dc.contributor.authorSaudou, Frédéric-
dc.contributor.authorWeil, Miguel-
dc.contributor.authorNguyen, Laurent-
dc.date.accessioned2020-01-23T08:21:59Z-
dc.date.available2020-01-23T08:21:59Z-
dc.date.issued2019-
dc.date.submitted2020-01-23T07:33:29Z-
dc.identifier.citationSCIENCE ADVANCES, 5 (12) (Art N° ARTN eaax2705)-
dc.identifier.urihttp://hdl.handle.net/1942/30370-
dc.description.abstractMicrotubules are polymerized dimers of -and -tubulin that underlie a broad range of cellular activities. Acetylation of -tubulin by the acetyltransferase ATAT1 modulates microtubule dynamics and functions in neurons. However, it remains unclear how this enzyme acetylates microtubules over long distances in axons. Here, we show that loss of ATAT1 impairs axonal transport in neurons in vivo, and cell-free motility assays confirm a requirement of -tubulin acetylation for proper bidirectional vesicular transport. Moreover, we demonstrate that the main cellular pool of ATAT1 is transported at the cytosolic side of neuronal vesicles that are moving along axons. Together, our data suggest that axonal transport of ATAT1-enriched vesicles is the predominant driver of -tubulin acetylation in axons.-
dc.description.sponsorshipA.E.’s stay at GIGA Research Institute of the University of Liège was funded by EMBO Short-Term Fellowships (ASTF 174-2016); his stay at F.S.’s lab was supported by TAU Global Research and Training Fellowship, Ela Kodesz Institute, and the Scientific and Academic Cooperation Office of the French embassy in Tel Aviv. A.E., M.S., and M.W.’s research was supported by the Israel Science Foundation (grant no. 1688/16). C.S. was supported by a Postdoctoral fellowship from FRM and by EMBO LTF (ALTF 693-2015). S.T., L.B., L.N., and B.M. are PhD fellow, Postdoctoral fellow, Senior Research Associates and Director from FRS-FNRS, respectively. This work was supported by the FRS-FNRS, the Fonds Léon Fredericq (L.N. and B.M.), the Fondation Médicale Reine Elisabeth (L.N. and B.M.), the Fondation Simone et Pierre Clerdent (L.N.), the Belgian Science Policy [IAP-VII network P7/20 (L.N.) and IAP-VII network P7/10 (B.B.)], and the ERANET Neuron STEM-MCD and NeuroTalk (L.N.); grants from Agence Nationale de la Recherche [ANR-14-CE35-0027-01 PASSAGE (F.S.), ANR-15-JPWG-0003-05 JPND CIRCPROT (F.S.), ANR-15-IDEX-02 NeuroCoG (F.S.), ANR-10-IDEX-0001-02, and ANR-11-LBX-003 (C.J.) in the framework of the “Investissements d’avenir” program]; the LABEX celtisphybio 8 (C.J.); and the Fondation pour la Recherche Médicale (FRM, équipe labellisée, to F.S.). C.J. is supported by the Institut Curie, the French National Research Agency (ANR) award ANR-17-CE13-0021 and the Fondation pour la Recherche Medicale (FRM) grant DEQ20170336756. J.A.S. was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 675737 and the FRM grant FDT201904008210. M.M.M. was supported by the Fondation Vaincre Alzheimer (grant no. FR-16055p).-
dc.language.isoen-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.rightsCopyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).-
dc.subject.otherTubulin Acetyltransferase 1-
dc.subject.otherBinding-
dc.subject.otherMec-17-
dc.subject.otherGlycolysis-
dc.subject.otherDeficiency-
dc.subject.otherMechanisms-
dc.subject.otherInhibitor-
dc.subject.otherEnergy-
dc.subject.otherModel-
dc.subject.otherLeads-
dc.titleATAT1-enriched vesicles promote microtubule acetylation via axonal transport-
dc.typeJournal Contribution-
dc.identifier.issue12-
dc.identifier.volume5-
local.bibliographicCitation.jcatA1-
local.publisher.place1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnrARTN eaax2705-
local.relation.h2020675737-
dc.source.typeArticle-
dc.identifier.doi10.1126/sciadv.aax2705-
dc.identifier.pmid31897425-
dc.identifier.isiWOS:000505069600030-
dc.identifier.eissn-
local.provider.typePdf-
local.uhasselt.uhpubyes-
item.contributorEven, Aviel-
item.contributorMORELLI, Giovanni-
item.contributorBroix, Loïc-
item.contributorScaramuzzino, Chiara-
item.contributorTurchetto, Silvia-
item.contributorGladwyn-Ng, Ivan-
item.contributorLe Bail, Romain-
item.contributorShilian, Michal-
item.contributorFreeman, Stephen-
item.contributorMagiera, Maria-
item.contributorJijumon, A-
item.contributorKrusy, Nathalie-
item.contributorMalgrange, Brigitte-
item.contributorBRONE, Bert-
item.contributorDietrich, Paula-
item.contributorDragatsis, Ioannis-
item.contributorJanke, Carsten-
item.contributorSaudou, Frédéric-
item.contributorWeil, Miguel-
item.contributorNguyen, Laurent-
item.accessRightsRestricted Access-
item.fullcitationEven, Aviel; MORELLI, Giovanni; Broix, Loïc; Scaramuzzino, Chiara; Turchetto, Silvia; Gladwyn-Ng, Ivan; Le Bail, Romain; Shilian, Michal; Freeman, Stephen; Magiera, Maria; Jijumon, A; Krusy, Nathalie; Malgrange, Brigitte; BRONE, Bert; Dietrich, Paula; Dragatsis, Ioannis; Janke, Carsten; Saudou, Frédéric; Weil, Miguel & Nguyen, Laurent (2019) ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. In: SCIENCE ADVANCES, 5 (12) (Art N° ARTN eaax2705).-
item.fulltextWith Fulltext-
crisitem.journal.issn2375-2548-
crisitem.journal.eissn2375-2548-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
Even-2019.pdf
  Restricted Access		Published version1.69 MBAdobe PDFView/Open    Request a copy
Show simple item record

SCOPUSTM   
Citations

2
checked on Sep 2, 2020

WEB OF SCIENCETM
Citations

29
checked on Apr 30, 2024

Page view(s)

46
checked on Sep 6, 2022

Download(s)

8
checked on Sep 6, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.