Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30372
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dc.contributor.authorPEREZ FONT, Lena-
dc.contributor.authorCardonne, Miriam-
dc.contributor.authorKEMPS, Hannelore-
dc.contributor.authorMEESEN, Raf-
dc.contributor.authorSalmon, Oneida-
dc.contributor.authorGonzález, Fidel-
dc.contributor.authorLAMBRICHTS, Ivo-
dc.contributor.authorRIGO, Jean-Michel-
dc.contributor.authorBRONE, Bert-
dc.contributor.authorBRONCKAERS, Annelies-
dc.date.accessioned2020-01-23T08:48:15Z-
dc.date.available2020-01-23T08:48:15Z-
dc.date.issued2019-
dc.date.submitted2020-01-23T07:37:19Z-
dc.identifier.citationFrontiers in Neuroscience, 13 (Art N° ARTN 561)-
dc.identifier.urihttp://hdl.handle.net/1942/30372-
dc.description.abstractDespite the high prevalence and devastating outcome, only a few treatment options for cerebral ischemic stroke exist. Based on the nitric oxide (NO)-stimulating capacity of Non-pulsed Sinusoidal Electromagnetic Field (NP-SEMF) and the possible neuroprotective role of NO in ischemic stroke, we hypothesized that NP-SEMF is able to enhance survival and neurological outcome in a rat model of cerebral ischemia. The animals, in which ischemic injury was induced by occlusion of both common carotid arteries, received 20 min of NP-SEMF of either 10 or 60 Hz daily for 4 days. NP-SEMF dramatically increased survival, reduced the size of the infarcted brain area and significantly improved the neurological score of the surviving rats. Corresponding to previous reports, NP-SEMF was able to induce NO production in vitro. The importance of NO as a key signaling molecule was highlighted by inhibition of the NP-SEMF beneficial effects in the rat stroke model after blocking NO synthase (NOS). Our results indicate for the first time that NP-SEMF exposure (13.5 mT at 60 and 10 Hz) improves the survival and neurological outcome of rats subjected to cerebral ischemia and that this effect is mediated by NO, underlining the great therapeutic potential of NP-SEMF as a therapy for ischemic stroke.-
dc.description.sponsorshipThis work was supported by the Belgian Development Cooperation through VLIR-UOS (Flemish Interuniversity Council-University Cooperation for Development) in the context of the Institutional University Cooperation Program with Universidad de Oriente and the Institutional Research Founds of the Centro Nacional de Electromagnetismo Aplicado, Cuba, and through BOF-BILA, doctoral grants in the framework of the bilateral cooperation, University Hasselt. AB benefits from a research grant of the FWO (Research Foundation – FlandersGrant Nos. 1266015N and 1522518N).-
dc.language.isoen-
dc.publisherFRONTIERS MEDIA SA-
dc.rights2019 Font, Cardonne, Kemps, Meesen, Salmon, González, Lambrichts, Rigo, Brône and Bronckaers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.-
dc.subject.othercerebral ischemia-
dc.subject.othernitric oxide-
dc.subject.otherelectromagnetic field-
dc.subject.otherendothelial cell-
dc.subject.otherneuroprotection-
dc.titleNon-pulsed Sinusoidal Electromagnetic Field Rescues Animals From Severe Ischemic Stroke via NO Activation-
dc.typeJournal Contribution-
dc.identifier.volume13-
local.bibliographicCitation.jcatA1-
local.publisher.placeAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnrARTN 561-
dc.source.typeArticle-
dc.identifier.doi10.3389/fnins.2019.00561-
dc.identifier.pmid31275094-
dc.identifier.isiWOS:000472043600001-
dc.identifier.eissn-
local.provider.typePdf-
local.uhasselt.uhpubyes-
item.contributorPEREZ FONT, Lena-
item.contributorCardonne, Miriam-
item.contributorKEMPS, Hannelore-
item.contributorMEESEN, Raf-
item.contributorSalmon, Oneida-
item.contributorGonzález, Fidel-
item.contributorLAMBRICHTS, Ivo-
item.contributorRIGO, Jean-Michel-
item.contributorBRONE, Bert-
item.contributorBRONCKAERS, Annelies-
item.fulltextWith Fulltext-
item.validationecoom 2020-
item.fullcitationPEREZ FONT, Lena; Cardonne, Miriam; KEMPS, Hannelore; MEESEN, Raf; Salmon, Oneida; González, Fidel; LAMBRICHTS, Ivo; RIGO, Jean-Michel; BRONE, Bert & BRONCKAERS, Annelies (2019) Non-pulsed Sinusoidal Electromagnetic Field Rescues Animals From Severe Ischemic Stroke via NO Activation. In: Frontiers in Neuroscience, 13 (Art N° ARTN 561).-
item.accessRightsOpen Access-
crisitem.journal.eissn1662-453X-
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