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http://hdl.handle.net/1942/30373
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DC Field | Value | Language |
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dc.contributor.author | Torre-Muruzabal, Teresa | - |
dc.contributor.author | DEVOGHT, Jens | - |
dc.contributor.author | Van Den Haute, Chris | - |
dc.contributor.author | Van Der Perren, Anke | - |
dc.contributor.author | BRONE, Bert | - |
dc.contributor.author | Baekelandt, Veerle | - |
dc.date.accessioned | 2020-01-23T09:22:25Z | - |
dc.date.available | 2020-01-23T09:22:25Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-01-23T07:20:45Z | - |
dc.identifier.citation | Acta Neuropathologica Communications, 7 (1) (Art N° ARTN 160) | - |
dc.identifier.uri | http://hdl.handle.net/1942/30373 | - |
dc.description.abstract | Aggregation of alpha-synuclein (α-SYN) is the pathological hallmark of several diseases named synucleinopathies, including Parkinson's disease (PD), which is the most common neurodegenerative motor disorder. Alpha-SYN has been linked to synaptic function both in physiological and pathological conditions. However, the exact link between neuronal activity, α-SYN toxicity and disease progression in PD is not clear. In this study, we aimed to investigate the effect of chronic neuromodulation in an α-SYN-based rat model for PD using chemogenetics. To do this, we expressed excitatory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) combined with mutant A53T α-SYN, using two different recombinant adeno-associated viral (rAAV) vectors (serotypes 2/7 and 2/8) in rat substantia nigra (SN) and investigated the effect on motor behavior, synapses and neuropathology. We found that chronic neuromodulation aggravates motor deficits induced by α-SYN, without altering dopaminergic neurodegeneration. In addition, neuronal activation led to changes in post-translational modification and subcellular localization of α-SYN, linking neuronal activity to the pathophysiological role of α-SYN in PD. | - |
dc.description.sponsorship | This work was supported by the FWO Flanders (Projects G.0927.14, G080517 N, PhD fellowship to Teresa Torre-Muruzabal and postdoctoral fellowship to Anke Van der Perren), the KU Leuven (OT/14/120, C14/18/102), the ERA-NET JPco-fuND 2015 SYNACTION, and the Medical Foundation Queen Elisabeth. | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.rights | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.subject.other | α-Synuclein | - |
dc.subject.other | DREADDs | - |
dc.subject.other | Neuronal activity | - |
dc.subject.other | Parkinson's disease | - |
dc.title | Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | ARTN 160 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1186/s40478-019-0814-3 | - |
dc.identifier.pmid | 31640762 | - |
dc.identifier.isi | WOS:000491886700002 | - |
dc.identifier.eissn | - | |
local.provider.type | - | |
local.uhasselt.uhpub | yes | - |
item.fullcitation | Torre-Muruzabal, Teresa; DEVOGHT, Jens; Van Den Haute, Chris; Van Der Perren, Anke; BRONE, Bert & Baekelandt, Veerle (2019) Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease. In: Acta Neuropathologica Communications, 7 (1) (Art N° ARTN 160). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
item.contributor | Torre-Muruzabal, Teresa | - |
item.contributor | DEVOGHT, Jens | - |
item.contributor | Van Den Haute, Chris | - |
item.contributor | Van Der Perren, Anke | - |
item.contributor | BRONE, Bert | - |
item.contributor | Baekelandt, Veerle | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2051-5960 | - |
crisitem.journal.eissn | 2051-5960 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Torre-Muruzabal-2019.pdf | Published version | 2.02 MB | Adobe PDF | View/Open |
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