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http://hdl.handle.net/1942/30429
Title: | Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds | Authors: | SCHEPERS, Melissa MARTENS, Nikita TIANE, Assia VANBRABANT, Kenneth Liu, Hong-Bing Lütjohann, Dieter Mulder, Monique VANMIERLO, Tim |
Issue Date: | 2020 | Publisher: | WOLTERS KLUWER MEDKNOW PUBLICATIONS | Source: | Neural Regeneration Research, 15 (5) , p. 790 -795 | Abstract: | Edible marine algae, or seaweeds, are a rich source of several bioactive compounds including phytosterols, carotenoids, and polysaccharides. Over the last decades, seaweed-derived constituents turned out to not only reside in the systemic circulation, but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions. Therefore, seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties, rendering them interesting candidates for the management of several neurodegenerative disorders. In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity, enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties. Though, the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids, phenols and polysaccharides have recently gained more interest. In this review, we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols. | Keywords: | algae;carotenoids;neuro-active;phenols;phytosterols;polysaccharides;seaweed | Document URI: | http://hdl.handle.net/1942/30429 | ISSN: | 1673-5374 | e-ISSN: | 1876-7958 | DOI: | 10.4103/1673-5374.268894 | ISI #: | WOS:000507630200003 | Rights: | Open access statement: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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NeuralRegenRes155790-5234287_143222.pdf | Published version | 607.92 kB | Adobe PDF | View/Open |
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