Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30570
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dc.contributor.advisorReniers-
dc.contributor.authorBIANCHI, Anna-
dc.contributor.authorSelva, A.-
dc.contributor.authorColautti, P.-
dc.contributor.authorBortot, D.-
dc.contributor.authorMazzucconi, D.-
dc.contributor.authorPola, A.-
dc.contributor.authorAgosteo, S.-
dc.contributor.authorPetringa, G.-
dc.contributor.authorCirrone, G.A.P.-
dc.contributor.authorRENIERS, Brigitte-
dc.contributor.authorParis, A.-
dc.contributor.authorStruelens, L.-
dc.contributor.authorVanhavere, F.-
dc.contributor.authorConte, V.-
dc.date.accessioned2020-02-21T10:47:06Z-
dc.date.available2020-02-21T10:47:06Z-
dc.date.issued2020-
dc.date.submitted2020-02-19T14:04:33Z-
dc.identifier.citationRADIATION PHYSICS AND CHEMISTRY, 171 (Art N° 108730)-
dc.identifier.issn0969-806X-
dc.identifier.urihttp://hdl.handle.net/1942/30570-
dc.description.abstractA sealed miniaturized Tissue Equivalent Proportional Counter (mini-TEPC) able to work in gas-steady modality was developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL – INFN, Legnaro, Italy). The aim of the present work is to compare the response of this mini-TEPC with that of a silicon microdosimeter based on a monolithic telescope. Pairwise measurements were performed at the 62 MeV proton clinical Spread Out Bragg Peak (SOBP) of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). The dose mean lineal energy values were derived from the spectra measured with the two detectors and compared with the total doseaveraged LET calculated by means of Geant4 Monte Carlo simulations. Finally, the possibility to apply the Microdosimetric Kinetic Model (MKM) to reproduce RBE variations with depth along the Spread Out Bragg Peak was investigated.-
dc.description.sponsorshipThis work was supported by the 5th Scientific Commission of the Italian Institute for Nuclear Physics (INFN), the Belgian nuclear research Centre SCK•CEN and Hasselt University. This work has been partially supported by the ENEN+ project that has received funding from the EURATOM research and training Work Programme 2016 – 2017 – 1 #755576.-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.rights2020 Elsevier Ltd. All rights reserved-
dc.subject.otherMicrodosimetry-
dc.subject.otherProton therapy-
dc.subject.otherMini-TEPC-
dc.subject.otherSilicon telescope-
dc.subject.otherBeam quality-
dc.titleMicrodosimetry with a sealed mini-TEPC and a silicon telescope at a clinical proton SOBP of CATANA-
dc.typeJournal Contribution-
local.bibliographicCitation.authorsChantler, Christopher-
local.bibliographicCitation.conferencedateMAY 27-31, 2019-
local.bibliographicCitation.conferencename3rd International Conference on Dosimetry and its Applications (ICDA)-
local.bibliographicCitation.conferenceplaceInst Super Tecnico, Lisbon, PORTUGAL-
dc.identifier.volume171-
local.format.pages7-
local.bibliographicCitation.jcatA1-
local.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND-
dc.relation.referencesAgosteo, S., et al., 2006. A solid state microdosimeter based on a monolithic silicon telescope. Radiat. Protect. Dosim. 122 (1-4), 382–386. Agosteo, S., et al., 2010. Study of a silicon telescope for solid state microdosimetry: preliminary measurements at the therapeutic proton beam line of CATANA. Radiat. Meas. 45, 1284–1289. Allison, J., et al., 2016. Recent developments in GEANT4. Nucl. Instrum. Methods A 835, 186–225. Chaudary, P., et al., 2014. Relative biological effectiveness along monoenergetic and modulated Bragg peaks of a 62-MeV therapeutic proton beam: a preclinical assessment. Int. J. Radiat. Oncol. Biol. Phys. 90 (1), 27–35. Chiriotti, S., et al., 2015. Equivalence of pure propane and propane TE gases for microdosimetric measurements. Radiat. Protect. Dosim. 166 (1-4), 242–246. Cirrone, G.A.P., et al., 2005. The geant4 toolkit capability in the hadron therapy field: simulation of a transport beam line. Nucl. Phys. B 150, 54–57. Conte, V., et al., 2013. Lineal energy calibration of mini tissue equivalent gas- proportional counters (TEPC), Multidisciplinary Applications of Nuclear Physics with Ion Beams (ION BEAMS ’12). AIP Conf. Proc. 1530, 171–178. Conte, V., et al., 2019. Microdosimetry at the CATANA 62 MeV proton beam with a sealed miniaturized TEPC. Phys. Med. 62, 114–122. De Nardo, L., et al., 2004. Mini-TEPCs for radiation therapy. Radiat. Protect. Dosim. 108 (4), 345–352. Debrot, E., et al., 2018. SOI microdosimetry and modified MKM for evaluation of relative biological effectiveness for a passive proton therapy radiation field. Phys. Med. Biol. 63. Gerdung, S., et al., 1995. Operation and application of tissue equivalent proportional counters. Radiat. Protect. Dosim. 61, 381–404. International Commission on Radiation Units and Measurement (ICRU), 1983. Microdosimetry. Report. vol. 36. International Commission on Radiation Units and Measurement (ICRU), 2007. Prescribing, Recording, and Reporting Proton Beam Therapy. Report. 78. Kase, Y., et al., 2006. Microdosimetric measurements and estimation of human cell survival for heavy-ion beams. Radiat. Res. 166, 629–638. Kellerer, A.M., et al., 1972. The theory of dual radiation action. Curr. Top. Radiat. Res. 8, 85–158. Magrin, G., 2018. Microdosimetry in Ion-Beam Therapy: Studying and Comparing Outcomes from Different Detectors. arXiv preprint arXiv:1802.06705. . Menzel, H.G., et al., 1990. Microdosimetric specification of radiation quality in neutron radiation therapy. Int. J. Radiat. Biol. 57, 865–883. P Cirrone, G.A., et al., 2004. A 62-MeV proton beam for the treatment of ocular melanoma at Laboratori Nazionali del Sud-INFN. IEEE Trans. Nucl. Sci. 51 (3), 860–865. Paganetti, H., 2014. Relative Biological Effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Phys. Med. Biol. 59 (22), R419–R472. Petringa, G., et al., 2017. Development and analysis of the track-LET, dose-LET and RBE calculations with a therapeutical proton and ion beams using Geant4 Monte Carlo code. Phys. Med. 42 (1), 9. Romano, F., et al., 2014. A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. Phys. Med. Biol. 59, 2863–2882. Rosenfeld, A.B., et al., 2000. A new silicon detector for microdosimetry applications in proton therapy. IEEE Trans. Nucl. Sci. 47 (4), 1386–1394. Wambersie, A., et al., 1990. The role of microdosimetry in radiotherapy. Radiat. Protect. Dosim. 31, 421–432. Ward, J.F., 1985. Biochemistry of DNA lesions. Radiat. Res. 104 (2s), S103–S111. Ziegler, J.F., et al., 2010. SRIM the stopping and range of ions in matter. Nucl. Instrum. Methods B 268, 1818–1823.-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr108730-
dc.identifier.doi10.1016/j.radphyschem.2020.108730-
dc.identifier.isiWOS:000525947600053-
dc.identifier.eissn-
local.provider.typePdf-
local.uhasselt.uhpubyes-
local.uhasselt.internationalyes-
item.validationecoom 2021-
item.accessRightsOpen Access-
item.fullcitationBIANCHI, Anna; Selva, A.; Colautti, P.; Bortot, D.; Mazzucconi, D.; Pola, A.; Agosteo, S.; Petringa, G.; Cirrone, G.A.P.; RENIERS, Brigitte; Paris, A.; Struelens, L.; Vanhavere, F. & Conte, V. (2020) Microdosimetry with a sealed mini-TEPC and a silicon telescope at a clinical proton SOBP of CATANA. In: RADIATION PHYSICS AND CHEMISTRY, 171 (Art N° 108730).-
item.fulltextWith Fulltext-
item.contributorBIANCHI, Anna-
item.contributorSelva, A.-
item.contributorColautti, P.-
item.contributorBortot, D.-
item.contributorMazzucconi, D.-
item.contributorPola, A.-
item.contributorAgosteo, S.-
item.contributorPetringa, G.-
item.contributorCirrone, G.A.P.-
item.contributorRENIERS, Brigitte-
item.contributorParis, A.-
item.contributorStruelens, L.-
item.contributorVanhavere, F.-
item.contributorConte, V.-
crisitem.journal.issn0969-806X-
crisitem.journal.eissn1879-0895-
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