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http://hdl.handle.net/1942/30593
Title: | Sargassum fusiforme improves memory and reduces amyloid plaque pathology in an Alzheimer's disease mouse model | Authors: | BOGIE, Jeroen HOEKS, Cindy SCHEPERS, Melissa TIANE, Assia CUYPERS, Ann Leijten, F. Chintapakorn, Y. Suttyut, T. Pornpakakul, S. Struik, D. Kerksiek, A. Liu, H. HELLINGS, Niels Martinez-Marinez, P. Jonker, J. DEWACHTER, Ilse Sijbrands, E. Walter, J. HENDRIKS, Jerome Groen, A. Staels, B. Luetjohann, D. Mulder, M. VANMIERLO, Tim |
Issue Date: | 2019 | Publisher: | WILEY | Source: | GLIA, 67 , p. E430 -E430 (Art N° T11-001B) | Abstract: | We hypothesized that the seaweed-derived LXRβ agonist 24(S)-Saringosterol enhances cognition in an animal model of AD without affecting plasma and hepatic triglycerides. Activation of liver X receptors (LXRs) by full LXR agonists was found to improve cognition in Alzheimer's disease (AD) mice. However, these full LXR agonists induce LXRα-mediated hypertriglyceridemia and hepatic steatosis, hampering their use in the clinic. Previously, we found that a lipid extract of the 24(S)-Saringosterol-containing seaweed Sargassum fusiforme did mainly activate LXRβ 1 . | Document URI: | http://hdl.handle.net/1942/30593 | Link to publication/dataset: | https://www.eventclass.org/contxt_glia2019/online-program/session?s=PS+II+-+11#e417 | ISSN: | 0894-1491 | e-ISSN: | 1098-1136 | ISI #: | WOS:000502867402142 | Rights: | Copyright © 2020 EventClass GmbH. All rights reserved. | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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