Sargassum fusiforme improves memory and reduces amyloid plaque pathology in an Alzheimer's disease mouse model

Abstract

We hypothesized that the seaweed-derived LXRβ agonist 24(S)-Saringosterol enhances cognition in an animal model of AD without affecting plasma and hepatic triglycerides. Activation of liver X receptors (LXRs) by full LXR agonists was found to improve cognition in Alzheimer's disease (AD) mice. However, these full LXR agonists induce LXRα-mediated hypertriglyceridemia and hepatic steatosis, hampering their use in the clinic. Previously, we found that a lipid extract of the 24(S)-Saringosterol-containing seaweed Sargassum fusiforme did mainly activate LXRβ 1 .