Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30606
Title: | Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial) | Authors: | Chang, Chun Chin Spitzer, Ernest Chichareon, Ply Takahashi, Kuniaki Modolo, Rodrigo Kogame, Norihiro Tomaniak, Mariusz Komiyama, Hidenori Yap, Sing-Chien Hoole, Stephen P. Gori, Tommaso Zaman, Azfar Frey, Bernhard Ferreira, Rui Cruz Bertrand, Olivier F. Koh, Tian Hai Sousa, Amanda Moschovitis, Aris van Geuns, Robert-Jan Steg, Philippe Gabriel Hamm, Christian Juni, Peter VRANCKX, Pascal Valgimigli, Marco Windecker, Stephan Serruys, Patrick W. Soliman, Osama Onuma, Yoshinobu |
Issue Date: | 2019 | Publisher: | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | Source: | AMERICAN JOURNAL OF CARDIOLOGY, 124 (12) , p. 1833 -1840 | Abstract: | Q-wave myocardial infarction (QWMI) comprises 2 entities. First, a clinically evident MI, which can occur spontaneously or be related to a coronary procedure. Second, silent MI which is incidentally detected on serial electrocardiographic (ECG) assessment. The prevalence of silent MI after percutaneous coronary intervention (PCI) in the drug-eluting stent era has not been fully investigated. The GLOBAL LEADERS is an all-corners multicenter trial which randomized 15,991 patients who underwent PCI to 2 antiplatelet treatment strategies. The primary end point was a composite of all-cause death or nonfatal new QWMI at 2-years follow-up. ECGs were collected at discharge, 3-month and 2-year visits, and analyzed by an independent ECG core laboratory following the Minnesota code. All new QWMI were further reviewed by a blinded independent cardiologist to identify a potential clinical correlate by reviewing clinical information. Of 15,968 participants, ECG information was complete in 14,829 (92.9%) at 2 years. A new QWMI was confirmed in 186 (1.16%) patients. Transient new Q-waves were observed in 28.5% (53 of 186) of them during the follow-up. The majority of new QWMI (78 %, 146 of 186) were classified as silent MI due to the absence of a clinical correlate. Silent MI accounted for 22.1% (146 of 660) of all MI events. The prevalence of silent MI did not differ significantly between treatment strategies (experimental vs reference: 0.88% vs 0.98%, p = 0.5027). In conclusion, we document the prevalence of silent MI in an all-corners population undergoing PCI in this large-scale randomized trial. | Notes: | Serruys, PW (reprint author), Imperial Coll London, NHLI, London, England. patrick.w.j.c.serruys@gmail.com |
Other: | Serruys, PW (reprint author), Imperial Coll London, NHLI, London, England. patrick.w.j.c.serruys@gmail.com | Keywords: | Q-Wave;Classification;Novacode | Document URI: | http://hdl.handle.net/1942/30606 | ISSN: | 0002-9149 | e-ISSN: | 1879-1913 | DOI: | 10.1016/j.amjcard.2019.08.049 | ISI #: | WOS:000503909900005 | Rights: | (C) 2019 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
chun.pdf Restricted Access | Published version | 1.14 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
1
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
4
checked on Jul 27, 2024
Page view(s)
34
checked on Jul 20, 2022
Download(s)
2
checked on Jul 20, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.