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http://hdl.handle.net/1942/3063
Title: | Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting | Authors: | STINISSEN, Piet RAUS, Jef |
Issue Date: | 1999 | Publisher: | ACTA MEDICA BELGICA | Source: | ACTA NEUROLOGICA BELGICA, 99(1). p. 65-69 | Abstract: | Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by autoreactive T cells with specificity for myelin antigens. The identity of the brain antigens, which are the primary targets of the autoimmune process remains unknown, but myelin basic protein (MBP) is a likely candidate. We will overview some of the experimental evidence, suggesting that MBP reactive T cells hold a central position in the pathogenesis of MS, and discuss how these autoreactive T cells can be therapeutically targeted by T cell vaccination. | Notes: | Limburgs Univ Ctr, Dr L Willems Inst, B-3590 Diepenbeek, Belgium.Stinissen, P, Limburgs Univ Ctr, Dr L Willems Inst, Univ Campus, B-3590 Diepenbeek, Belgium. | Keywords: | multiple sclerosis; autoreactive T cells; autoimmunity; immunotherapy; myelin basic protein | Document URI: | http://hdl.handle.net/1942/3063 | ISI #: | 000079794900011 | Type: | Journal Contribution | Validations: | ecoom 2000 |
Appears in Collections: | Research publications |
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