Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30658
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alagappan, V. K. T. | - |
dc.contributor.author | McKay, S. | - |
dc.contributor.author | WIDYASTUTI, Anna | - |
dc.contributor.author | Garrelds, I. M. | - |
dc.contributor.author | Bogers, A. J. J. C. | - |
dc.contributor.author | Hoogsteden, H. C. | - |
dc.contributor.author | Hirst, S. J. | - |
dc.contributor.author | Sharma, H. S. | - |
dc.date.accessioned | 2020-03-04T08:16:18Z | - |
dc.date.available | 2020-03-04T08:16:18Z | - |
dc.date.issued | 2005 | - |
dc.date.submitted | 2020-03-04T08:13:47Z | - |
dc.identifier.citation | Cell Biochemistry and Biophysics, 43 (1) , p. 119 -129 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30658 | - |
dc.description.abstract | Airflow obstruction in chronic airway disease is associated with airway and pulmonary vascular remodeling, of which the molecular mechanisms are poorly understood. Paracrine actions of angiogenic factors released by resident or infiltrating inflammatory cells following activation by proinflammatory cytokines in diseased airways could play a major role in the airway vascular remodeling process. Here, the proinflammatory cytokines interleukin (IL)-1 beta, and tumor necrosis factor (TNF)-alpha were investigated on cell cultures of human airway smooth muscle (ASM) for their effects on mRNA induction and protein release of the angiogenic peptide, vascular endothelial growth factor (VEGF). IL-1 beta (0.5 ng/mL) and TNF-alpha (10 ng/mL) each increased VEGF mRNA (3.9 and 1.7 kb) expression in human ASM cells, reaching maximal levels between 16 and 24 and 4 and 8 h, respectively. Both cytokines also induced a time-dependent release of VEGF, which was not associated with increased ASM growth. Preincubation of cells with I mu M dexamethasone abolished enhanced release of VEGF by TNF-alpha. The data suggest that human ASM cells express and secrete VEGF in response to proinflammatory cytokines and may participate in paracrine inflammatory mechanisms of vascular remodeling in chronic airway disease. | - |
dc.language.iso | en | - |
dc.publisher | Humana Press Inc. | - |
dc.rights | Copyright 2005 by Humana Press Inc | - |
dc.subject.other | cytokine | - |
dc.subject.other | vascular endothelial growth factor | - |
dc.subject.other | airway smooth muscle | - |
dc.subject.other | enzyme-linked immunosorbent assay | - |
dc.subject.other | human | - |
dc.title | Proinflammatory Cytokines Upregulate mRNA Expression and Secretion of Vascular Endothelial Growth Factor in Cultured Human Airway Smooth Muscle Cells | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencedate | JAN 13-15, 2004 | - |
local.bibliographicCitation.conferencename | 1st International Conference on Recent Advances in Biomedical and Therapeutic Sciences | - |
local.bibliographicCitation.conferenceplace | Bundelkhand Univ, Jhansi, INDIA | - |
dc.identifier.epage | 129 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 119 | - |
dc.identifier.volume | 43 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1385/CBB:43:1:119 | - |
dc.identifier.pmid | 16043889 | - |
dc.identifier.isi | WOS:000231426700012 | - |
dc.identifier.eissn | 1559-0283 | - |
local.provider.type | CrossRef | - |
local.uhasselt.uhpub | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Alagappan, V. K. T. | - |
item.contributor | McKay, S. | - |
item.contributor | WIDYASTUTI, Anna | - |
item.contributor | Garrelds, I. M. | - |
item.contributor | Bogers, A. J. J. C. | - |
item.contributor | Hoogsteden, H. C. | - |
item.contributor | Hirst, S. J. | - |
item.contributor | Sharma, H. S. | - |
item.fullcitation | Alagappan, V. K. T.; McKay, S.; WIDYASTUTI, Anna; Garrelds, I. M.; Bogers, A. J. J. C.; Hoogsteden, H. C.; Hirst, S. J. & Sharma, H. S. (2005) Proinflammatory Cytokines Upregulate mRNA Expression and Secretion of Vascular Endothelial Growth Factor in Cultured Human Airway Smooth Muscle Cells. In: Cell Biochemistry and Biophysics, 43 (1) , p. 119 -129. | - |
item.accessRights | Restricted Access | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Alagappan2005_Article_ProinflammatoryCytokinesUpregu.pdf Restricted Access | Published version | 207.25 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
40
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
47
checked on Oct 5, 2024
Page view(s)
22
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.