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http://hdl.handle.net/1942/30662
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2020-03-04T08:58:29Z | - |
dc.date.available | 2020-03-04T08:58:29Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-03T15:11:51Z | - |
dc.identifier.citation | ACTA CARDIOLOGICA, 75 (1) , p. 49 -53 | - |
dc.identifier.issn | 0001-5385 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30662 | - |
dc.description.abstract | Background: Absence of beta-blocker use independently predicts appropriate therapy. Following cardiac resynchronisation therapy (CRT) implant, reverse remodelling and protection against bradycardia allows for beta-blocker dose uptitration. The differential dosing effects on the occurrence of a first episode of appropriate therapy in primary prevention CRT-defibrillator (CRT-D) patients remains unstudied. Methods and Results: Changes in beta-blocker dose following CRT-D in consecutive primary prevention patients implanted between 2008 and 2015 were retrospectively studied. Beta-blocker dose was expressed as percent of target dose. Uptitration of beta-blocker dose following implant was calculated as the change in percent of target dose between implant and 6-months follow-up. Results from a prospectively maintained database of all device analysis were used to determine the occurrence of appropriate therapy. A total of 162 patients (68 +/- 8 years) were studied. One hundred and ten (68%) patients underwent uptitration (mean 47 +/- 19% in target dose) and 52 (32%) remained on a stable beta-blocker dose. During 37 +/- 22 months follow-up, the cumulative percent of appropriate therapy was 31% in patient receiving no-uptitration versus 10% in the uptitrated patients (p < 0.001). After correction for known predictors of appropriate therapy, uptitration was independently associated with an OR = 0.263 (CI = 0.103-0.675; p = 0.001) for the occurrence of appropriate therapy. Every 1%-increase in target dose for beta-blocker associated with a significant lower risk for appropriate therapy, OR = 0.982 (CI = 0.965-0.999; p = 0.042). Conclusion: Following implantation of a primary prevention CRT-D, uptitration of beta-blockers associated with a reduced occurrence of a first episode of appropriate therapy for ventricular arrhythmias. An inverse dose-response effect was seen between beta-blocker dose and appropriate therapy. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.rights | 2020 Informa UK Limited | - |
dc.subject.other | Beta-blockers | - |
dc.subject.other | appropriate therapy | - |
dc.subject.other | uptitration | - |
dc.subject.other | implantable cardioverter defibrillation | - |
dc.title | Reduced occurrence of appropriate therapy for ventricular arrhythmias after beta-blocker uptitration following implant of a primary prevention CRT-defibrillator | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 53 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 49 | - |
dc.identifier.volume | 75 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Martens, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | Pieter.martens2@zol.be | - |
dc.description.other | Martens, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. Pieter.martens2@zol.be | - |
local.publisher.place | 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1080/00015385.2018.1547469 | - |
dc.identifier.isi | WOS:000512642800007 | - |
dc.identifier.eissn | 1784-973X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.validation | ecoom 2021 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | MARTENS, Pieter; DUPONT, Matthias & MULLENS, Wilfried (2020) Reduced occurrence of appropriate therapy for ventricular arrhythmias after beta-blocker uptitration following implant of a primary prevention CRT-defibrillator. In: ACTA CARDIOLOGICA, 75 (1) , p. 49 -53. | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
crisitem.journal.issn | 0001-5385 | - |
crisitem.journal.eissn | 1784-973X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Reduced occurrence of appropriate therapy for ventricular arrhythmias after beta blocker uptitration following implant of a primary prevention CRT.pdf Restricted Access | Published version | 817.36 kB | Adobe PDF | View/Open Request a copy |
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