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http://hdl.handle.net/1942/30667
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DC Field | Value | Language |
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dc.contributor.author | DILLEN, Yorg | - |
dc.contributor.author | KEMPS, Hannelore | - |
dc.contributor.author | BRONCKAERS, Annelies | - |
dc.contributor.author | GERVOIS, Pascal | - |
dc.contributor.author | WOLFS, Esther | - |
dc.date.accessioned | 2020-03-04T11:22:46Z | - |
dc.date.available | 2020-03-04T11:22:46Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-04T10:26:49Z | - |
dc.identifier.citation | TRANSLATIONAL STROKE RESEARCH, 11 (1) , p. 60 -79 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30667 | - |
dc.description.abstract | Adult neurogenesis in the subventricular zone is a topic of intense research, since it has vast implications for the fundamental understanding of the neurobiology of the brain and its potential to being harnessed for therapy in various neurological disorders. Investigation of adult neurogenesis has been complicated by the difficulties with characterization of neural stem cells in vivo. However, recent single-cell transcriptomic studies provide more detailed information on marker expression in neural stem cells and their neuronal lineage, which hopefully will result in a more unified discussion. Regulation of the multiple biological steps in adult neurogenesis comprises intrinsic mechanisms as well as extrinsic factors which together orchestrate the process. In this review, we describe the regulating factors and their cellular sources in the physiological condition and provide an overview of the regulating factors mediating stroke-induced stimulation of neurogenesis in the subventricular zone. While there is ongoing debate about the longevity of active post-natal neurogenesis in humans, the subventricular zone has the capacity to upregulate neurogenesis in response to ischemic stroke. Though, the stroke-induced neurogenesis in humans does not seem to translate into adequate functional recovery, which opens discussion about potential treatment strategies to harness this neuroregenerative response. Various therapeutic approaches are explored in preclinical and clinical studies to target endogenous neurogenesis of which some are discussed in this review. | - |
dc.description.sponsorship | This study was funded by grants of "Fonds voor Wetenschappelijk Onderzoek" (FWO) Vlaanderen and Research Funds of Hasselt University. Yorg Dillen is a predoctoral researcher of the "Fonds Wetenschappelijk Onderzoek" (FWO) Vlaanderen. Pascal Gervois, Esther Wolfs, Yorg Dillen and Annelies Bronckaers are funded by FWO grants 12U7718N, G0A7514N, 1134717N, FWO1522518. Hannelore Kemps is funded by the Special Research Fund (BOF) of Hasselt University" (Grant number 18NI06BOF). | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.rights | Springer Science+Business Media, LLC, part of Springer Nature 2019 | - |
dc.subject.other | Adult neurogenesis | - |
dc.subject.other | Subventricular zone | - |
dc.subject.other | Ischemic stroke | - |
dc.subject.other | Neural stem cells | - |
dc.subject.other | Stroke therapy | - |
dc.title | Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 79 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 60 | - |
dc.identifier.volume | 11 | - |
local.format.pages | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bronckaers, A (reprint author), Hasselt Univ, UHasselt, Biomed Res Inst BIOMED, Res Grp Morphol, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | annelies.bronckaers@uhasselt.be | - |
dc.description.other | Bronckaers, A (reprint author), Hasselt Univ, UHasselt, Biomed Res Inst BIOMED, Res Grp Morphol, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. annelies.bronckaers@uhasselt.be | - |
local.publisher.place | ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.source.type | Review | - |
dc.identifier.doi | 10.1007/s12975-019-00717-8 | - |
dc.identifier.pmid | 31309427 | - |
dc.identifier.isi | WOS:000511871000007 | - |
dc.contributor.orcid | Bronckaers, Annelies/0000-0001-8969-873X; Wolfs, | - |
dc.contributor.orcid | Esther/0000-0001-9277-6524 | - |
dc.identifier.eissn | 1868-601X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.contributor | DILLEN, Yorg | - |
item.contributor | KEMPS, Hannelore | - |
item.contributor | BRONCKAERS, Annelies | - |
item.contributor | GERVOIS, Pascal | - |
item.contributor | WOLFS, Esther | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.fullcitation | DILLEN, Yorg; KEMPS, Hannelore; BRONCKAERS, Annelies; GERVOIS, Pascal & WOLFS, Esther (2020) Adult Neurogenesis in the Subventricular Zone and Its Regulation After Ischemic Stroke: Implications for Therapeutic Approaches. In: TRANSLATIONAL STROKE RESEARCH, 11 (1) , p. 60 -79. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1868-4483 | - |
crisitem.journal.eissn | 1868-601X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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yorg.pdf Restricted Access | Published version | 1.25 MB | Adobe PDF | View/Open Request a copy |
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