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http://hdl.handle.net/1942/30678
Title: | An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach | Authors: | DERA, Rafael DILIEN, Hanne ADRIAENSENS, Peter GUEDENS, Wanda CLEIJ, Thomas |
Issue Date: | 2020 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | MACROMOLECULAR CHEMISTRY AND PHYSICS, 221(5) (Art N° 1900466) | Abstract: | Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the foreign body response. In this work, phosphodiester-crosslinked hydrogels are produced by a simple free-radical polymerization of a phosphotriester crosslinker. In a second step, this material is transformed to the phosphodiester, by heating it up to 60 degrees C in phosphate-buffered saline. Compared to earlier methods, there is no need for acids, bases, or oxidizing agents to achieve this final conversion to the phosphodiester. This method thus reduces the risk to damage or degrade any sensitive biomolecules that might be of interest to tissue engineers, such as various growth factors or other proteins. The phosphotriester crosslinker is readily synthesized out of common laboratory chemicals in multigram quantities with good yield and easy workup and purification. | Notes: | Dilien, H (reprint author), Maastricht Univ, Fac Sci & Engn, Sensor Engn, Urmonderbaan 22,Chemelot Ctr Court Gebouw 200, NL-6167 RD Geleen, Netherlands. Hanne.dilien@maastrichtuniversity.nl |
Other: | Dilien, H (reprint author), Maastricht Univ, Fac Sci & Engn, Sensor Engn, Urmonderbaan 22,Chemelot Ctr Court Gebouw 200, NL-6167 RD Geleen, Netherlands. Hanne.dilien@maastrichtuniversity.nl | Keywords: | biomaterials;hydrogels;phosphodiesters | Document URI: | http://hdl.handle.net/1942/30678 | ISSN: | 1022-1352 | e-ISSN: | 1521-3935 | DOI: | 10.1002/macp.201900466 | ISI #: | WOS:000509798300001 | Rights: | 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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