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http://hdl.handle.net/1942/30686
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DC Field | Value | Language |
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dc.contributor.author | Verleden, S.E. | - |
dc.contributor.author | Vos, R. | - |
dc.contributor.author | Mertens, V. | - |
dc.contributor.author | Willems-Widyastuti, A. | - |
dc.contributor.author | De Vleeschauwer, S.I. | - |
dc.contributor.author | DUPONT, Tim | - |
dc.contributor.author | Verleden, G.M. | - |
dc.contributor.author | Van Raemdonck, D.E. | - |
dc.contributor.author | Vanaudenaerde, B.M. | - |
dc.date.accessioned | 2020-03-06T07:43:40Z | - |
dc.date.available | 2020-03-06T07:43:40Z | - |
dc.date.issued | 2011 | - |
dc.date.submitted | 2020-03-06T07:26:48Z | - |
dc.identifier.citation | Journal of Heart and Lung Transplantation, Journal of Heart and Lung Transplantation, 30 (6) , p. 667-673 -673 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30686 | - |
dc.description.abstract | BACKGROUND: Chronic lung allograft dysfunction (CLAD) remains a major risk factor for death after lung transplantation. Previous data suggested that within CLAD at least 2 phenotypes are present: a neutrophilic type (nCLAD or neutrophilic reversible allograft dysfunction [NRAD]), reversible with azithromycin therapy, vs a low neutrophilic type, non-responsive to azithromycin (fibrotic bronchiolitis obliterans syndrome [fBOS]). We aimed to further characterize this dichotomy by measuring multiple proteins in the bronchoalveolar lavage (BAL) fluid of 28 lung recipients.METHODS: Patients were retrospectively subdivided by the absence or presence of CLAD and subsequently by their response to azithromycin, resulting in 3 groups: 10 stable, 9 responsive (nCLAD/NRAD), and 9 non-responsive (fBOS). Enzyme-linked immunosorbent assay was used to measure 32 different proteins.RESULTS: Protein variations were predominantly present in the nCLAD/NRAD group, whereas no differences were observed in the fBOS group compared with control. MCP-1 (p < 0.01), RANTES (p < 0.05), IL-beta (p < 0.01), IL-8 (p < 0.01), TIMP-1 (p < 0.01), MMP-8 (p < 0.01), MMP-9 (p < 0.01), HGF (p < 0.001), MPO (p < 0.01), and bile acid (p < 0.05) concentrations were upregulated in nCLAD/NRAD compared with fBOS, whereas PDGF-AA (p < 0.05) was downregulated.CONCLUSIONS: These data provide further evidence that within CLAD there is a heterogeneity of phenotypes with different mechanisms involved. Further investigation is warranted to unravel the pathophysiology of both phenotypes. J Heart Lung Transplant 2011;30:667-73 (C) 2011 International Society for Heart and Lung Transplantation. All rights reserved. | - |
dc.language.iso | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.publisher | - | |
dc.subject.other | bronchiolitis obliterans syndrome | - |
dc.subject.other | chronic lung allograft dysfunction | - |
dc.subject.other | lung transplantation | - |
dc.subject.other | neutrophilic reversible allograft dysfunction | - |
dc.subject.other | bronchoalveolar lavage | - |
dc.subject.other | lung rejection | - |
dc.title | Heterogeneity of chronic lung allograft dysfunction: Insights from protein expression in broncho alveolar lavage | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 673 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 667-673 | - |
dc.identifier.volume | 30 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | journal-article | - |
dc.identifier.doi | 10.1016/j.healun.2010.12.008 | - |
dc.identifier.pmid | 21276737 | - |
dc.identifier.scopus | 2-s2.0-79955877424 | - |
dc.identifier.isi | WOS:000290834600009 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-79955877424&partnerID=MN8TOARS | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.identifier.eissn | - | |
dc.identifier.eissn | - | |
local.provider.type | Orcid | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Verleden, S.E.; Vos, R.; Mertens, V.; Willems-Widyastuti, A.; De Vleeschauwer, S.I.; DUPONT, Tim; Verleden, G.M.; Van Raemdonck, D.E. & Vanaudenaerde, B.M. (2011) Heterogeneity of chronic lung allograft dysfunction: Insights from protein expression in broncho alveolar lavage. In: Journal of Heart and Lung Transplantation, Journal of Heart and Lung Transplantation, 30 (6) , p. 667-673 -673. | - |
item.fulltext | No Fulltext | - |
item.contributor | Verleden, S.E. | - |
item.contributor | Vos, R. | - |
item.contributor | Mertens, V. | - |
item.contributor | Willems-Widyastuti, A. | - |
item.contributor | De Vleeschauwer, S.I. | - |
item.contributor | DUPONT, Tim | - |
item.contributor | Verleden, G.M. | - |
item.contributor | Van Raemdonck, D.E. | - |
item.contributor | Vanaudenaerde, B.M. | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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