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http://hdl.handle.net/1942/30743
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DC Field | Value | Language |
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dc.contributor.author | Kranenburg, A.R. | - |
dc.contributor.author | WIDYASTUTI, Anna | - |
dc.contributor.author | Mooi, W.J. | - |
dc.contributor.author | Saxena, P.R. | - |
dc.contributor.author | Sterk, P.J. | - |
dc.contributor.author | de Boer, W.I. | - |
dc.contributor.author | Sharma, H.S. | - |
dc.date.accessioned | 2020-03-11T07:51:33Z | - |
dc.date.available | 2020-03-11T07:51:33Z | - |
dc.date.issued | 2005 | - |
dc.date.submitted | 2020-03-11T07:30:11Z | - |
dc.identifier.citation | Journal of Pathology, 206 (1) , p. 28 -38 | - |
dc.identifier.issn | 0022-3417 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30743 | - |
dc.description.abstract | An important feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, the molecular mechanisms of which are poorly understood. In this study, the role of fibroblast growth factors (FGF-1 and FGF-2) and their receptor, FGFR-1, was assessed in bronchial airway wall remodelling in patients with COPD (FEV1 < 75%; n = 15) and without COPD (FEV1 > 85%; n = 16). FGF-1 and FGFR-1 were immunolocalized in bronchial epithelium, airway smooth muscle (ASM), submucosal glandular epithelium, and vascular smooth muscle. Quantitative digital image analysis revealed increased cytoplasmic expression of FGF-2 in bronchial epithelium (0.35 +/- 0.03 vs 0.20 +/- 0.04, p < 0.008) and nuclear localization in ASM (p < 0.0001) in COPD patients compared with controls. Elevated levels of FGFR-1 in ASM (p < 0.005) and of FGF-1 (p < 0.04) and FGFR-I (P < 0.001) in bronchial epithelium were observed. In cultured human ASM cells, FGF-1 and/or FGF-2 (10 ng/ml) induced cellular proliferation, as shown by [H-3]thymidine incorporation and by cell number counts. Steady-state mRNA levels of FGFR-1 were elevated in human ASM cells treated with either FGF-1 or FGF-2. The increased bronchial expression of fibroblast growth factors and their receptor in patients with COPD, and the mitogenic response of human ASM cells to FGFs in vitro suggest a potential role for the FGF/FGFR-1 system in the remodelling of bronchial airways in COPD. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. | - |
dc.subject.other | chronic obstructive pulmonary disease | - |
dc.subject.other | fibroblast growth factor | - |
dc.subject.other | airway remodelling | - |
dc.subject.other | airway smooth muscle | - |
dc.subject.other | gene expression | - |
dc.subject.other | human | - |
dc.title | Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF-1, FGF-2, and FGFR-1 | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 38 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 28 | - |
dc.identifier.volume | 206 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | journal-article | - |
dc.identifier.doi | 10.1002/path.1748 | - |
dc.identifier.pmid | 15772985 | - |
dc.identifier.scopus | 2-s2.0-18144406878 | - |
dc.identifier.isi | WOS:000228732600004 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-18144406878&partnerID=MN8TOARS | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.identifier.eissn | 1096-9896 | - |
local.provider.type | Orcid | - |
local.uhasselt.uhpub | no | - |
local.uhasselt.international | yes | - |
item.contributor | Kranenburg, A.R. | - |
item.contributor | WIDYASTUTI, Anna | - |
item.contributor | Mooi, W.J. | - |
item.contributor | Saxena, P.R. | - |
item.contributor | Sterk, P.J. | - |
item.contributor | de Boer, W.I. | - |
item.contributor | Sharma, H.S. | - |
item.fullcitation | Kranenburg, A.R.; WIDYASTUTI, Anna; Mooi, W.J.; Saxena, P.R.; Sterk, P.J.; de Boer, W.I. & Sharma, H.S. (2005) Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF-1, FGF-2, and FGFR-1. In: Journal of Pathology, 206 (1) , p. 28 -38. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0022-3417 | - |
crisitem.journal.eissn | 1096-9896 | - |
Appears in Collections: | Research publications |
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Andor_Kranenburg.pdf Restricted Access | Published version | 673.06 kB | Adobe PDF | View/Open Request a copy |
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