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http://hdl.handle.net/1942/30782
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DC Field | Value | Language |
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dc.contributor.author | van Gestel, Nicole A. P. | - |
dc.contributor.author | Gabriels, Floor | - |
dc.contributor.author | Geurts, Jan A. P. | - |
dc.contributor.author | Hulsen, Dennis J. W. | - |
dc.contributor.author | Wyers, Caroline E. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | Ito, Keita | - |
dc.contributor.author | Hofmann, Sandra | - |
dc.contributor.author | Arts, Jacobus J. | - |
dc.contributor.author | van Rietbergen, Bert | - |
dc.date.accessioned | 2020-03-12T13:10:01Z | - |
dc.date.available | 2020-03-12T13:10:01Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-02-19T10:49:05Z | - |
dc.identifier.citation | MATERIALS, 12 (21) (Art N° 3481) | - |
dc.identifier.uri | http://hdl.handle.net/1942/30782 | - |
dc.description.abstract | Bioactive glass (BAG) granules (S53P4) have shown good clinical results in one-stage treatment of osteomyelitis. During this treatment, a cortical window is created, and infected bone is debrided, which results in large defects that affect the mechanical properties of the bone. This study aimed to evaluate the role of BAG granules in load-bearing bone defect grafting. First, the influence of the geometry of the cortical window on the bone bending stiffness and estimated failure moments was evaluated using micro finite element analysis (mu FE). This resulted in significant differences between the variations in width and length. In addition, mu FE analysis showed that BAG granules contribute to bearing loads in simulated compression of a tibia with a defect grafted with BAG and a BAG and bone morsel mixture. These mixtures potentially can unload the cortical bone that is weakened by a large defect directly after the operation by up to approximately 25%, but only in case of optimal load transfer through the mixture. | - |
dc.description.sponsorship | This research was partly funded by the Women in Science and Engineering (WISE) funds of the Eindhoven University of Technology (WISE-2014-1004081). The APC was funded by Bonalive (R) Biomaterials Ltd. research funding. | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | osteomyelitis | - |
dc.subject.other | treatment | - |
dc.subject.other | bioactive glass granules | - |
dc.subject.other | stiffness | - |
dc.subject.other | mechanical properties | - |
dc.subject.other | finite element analysis | - |
dc.subject.other | load sharing | - |
dc.title | The Implantation of Bioactive Glass Granules Can Contribute the Load-Bearing Capacity of Bones Weakened by Large Cortical Defects | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 21 | - |
dc.identifier.volume | 12 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | van Rietbergen, B (reprint author), Eindhoven Univ Technol, Orthopaed Biomech, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands.; van Rietbergen, B (reprint author), Maastricht Univ, Med Ctr, Res Sch CAPHRI, Dept Orthopaed Surg, POB 5800, NL-6229 HX Maastricht, Netherlands. | - |
dc.description.notes | n.a.p.v.gestel@tue.nl; floor.gabriels@log-ten.com; j.geurts@mumc.nl; | - |
dc.description.notes | d.hulsen@jbz.nl; cwyers@viecuri.nl; jvdbergh@viecuri.nl; k.ito@tue.nl; | - |
dc.description.notes | s.hofmann@tue.nl; j.arts@mumc.nl; b.v.rietbergen@tue.nl | - |
dc.description.other | van Rietbergen, B (reprint author), Eindhoven Univ Technol, Orthopaed Biomech, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands, Maastricht Univ, Med Ctr, Res Sch CAPHRI, Dept Orthopaed Surg, POB 5800, NL-6229 HX Maastricht, Netherlands. n.a.p.v.gestel@tue.nl; floor.gabriels@log-ten.com; j.geurts@mumc.nl; d.hulsen@jbz.nl; cwyers@viecuri.nl; jvdbergh@viecuri.nl; k.ito@tue.nl; s.hofmann@tue.nl; j.arts@mumc.nl; b.v.rietbergen@tue.nl | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 3481 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.3390/ma12213481 | - |
dc.identifier.pmid | 31652996 | - |
dc.identifier.isi | WOS:000502798800022 | - |
dc.contributor.orcid | Geurts, Jan/0000-0002-0973-572X; Wyers, Caroline/0000-0001-7662-3990; | - |
dc.contributor.orcid | van Gestel, Nicole/0000-0003-0162-490X; Hofmann, | - |
dc.contributor.orcid | Sandra/0000-0002-2568-8388; Hulsen, Dennis/0000-0002-0850-1999 | - |
dc.identifier.eissn | 1996-1944 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.fullcitation | van Gestel, Nicole A. P.; Gabriels, Floor; Geurts, Jan A. P.; Hulsen, Dennis J. W.; Wyers, Caroline E.; VAN DEN BERGH, Joop; Ito, Keita; Hofmann, Sandra; Arts, Jacobus J. & van Rietbergen, Bert (2019) The Implantation of Bioactive Glass Granules Can Contribute the Load-Bearing Capacity of Bones Weakened by Large Cortical Defects. In: MATERIALS, 12 (21) (Art N° 3481). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
item.accessRights | Open Access | - |
item.contributor | van Gestel, Nicole A. P. | - |
item.contributor | Gabriels, Floor | - |
item.contributor | Geurts, Jan A. P. | - |
item.contributor | Hulsen, Dennis J. W. | - |
item.contributor | Wyers, Caroline E. | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | Ito, Keita | - |
item.contributor | Hofmann, Sandra | - |
item.contributor | Arts, Jacobus J. | - |
item.contributor | van Rietbergen, Bert | - |
crisitem.journal.eissn | 1996-1944 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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nicole.pdf | Published version | 3.99 MB | Adobe PDF | View/Open |
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