Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30795
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dc.contributor.authorCLEMENTE BATALHA PARDAL, Diana-
dc.contributor.authorMaitre, Lea-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorRoumeliotaki, Theano-
dc.contributor.authorFossati, Serena-
dc.contributor.authorGrazuleviciene, Regina-
dc.contributor.authorGutzkow, Kristine B.-
dc.contributor.authorLepeule, Johanna-
dc.contributor.authorMARTENS, Dries-
dc.contributor.authorMcEachan, Rosie R. C.-
dc.contributor.authorMeltzer, Helle M.-
dc.contributor.authorPetraviciene, Inga-
dc.contributor.authorSlama, Remy-
dc.contributor.authorTamayo-Uria, Ibon-
dc.contributor.authorUrquiza, Jose-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorWright, John-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorVrijheid, Martine-
dc.date.accessioned2020-03-13T13:56:46Z-
dc.date.available2020-03-13T13:56:46Z-
dc.date.issued2019-
dc.date.submitted2020-02-12T10:43:28Z-
dc.identifier.citationSCIENTIFIC REPORTS, 9 (1) (Art N° 18739)-
dc.identifier.urihttp://hdl.handle.net/1942/30795-
dc.description.abstractTelomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were used. Maternal pre-pregnancy body mass index (BMI) and 4 adiposity markers in children at age 8 (6-11) years were assessed: BMI, fat mass, waist circumference, and skinfold thickness. Relative LTL was obtained. Associations of LTL with each adiposity marker were calculated using linear mixed models with a random cohort effect. For each 1 kg/ m 2 increment in maternal pre-pregnancy BMI, the child's LTL was 0.23% shorter (95%CI: 0.01,0.46%). Each unit increase in child BMI z-score was associated with 1.21% (95%CI: 0.30,2.11%) shorter LTL. Inverse associations were observed between waist circumference and LTL (-0.96% per z-score unit; 95%CI: -2.06,0.16%), and skinfold thickness and LTL (-0.10% per z-score unit; 95%CI: -0.23,0.02%). In conclusion, this large multicentric study suggests that higher child adiposity indicators are associated with short telomeres in children, and that associations are stronger for child BMI than for maternal pre-pregnancy BMI.-
dc.description.sponsorshipThis work was supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 308333 - the HELIX project. INMA data collection was supported by grant C/from the Instituto de Salud Carlos III. This project has received funding from the European Union's Horizon 2020 research and innovation program under Grant Agreement No 774548. Tim S. Nawrot was funded by the EU Program "Ideas" (ERC-2012-StG 310898). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. We are grateful to all the participating families in the six countries who took part in this study.-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.-
dc.titleObesity is associated with shorter telomeres in 8 year-old children-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume9-
local.format.pages8-
local.bibliographicCitation.jcatA1-
dc.description.notesVrijheid, M (reprint author), Inst Global Hlth Barcelona, ISGlobal, C Doctor Aiguader 88, Barcelona 08003, Spain.; Vrijheid, M (reprint author), Univ Pompeu Fabra, Placa Merce 10, Barcelona 08002, Spain.; Vrijheid, M (reprint author), CIBER Epidemiol & Salud Publ CIBERESP, Ave Monforte de Lemos 3-5, Madrid, Spain.-
dc.description.notesmartine.vrijheid@isglobal.org-
dc.description.otherVrijheid, M (reprint author), Inst Global Hlth Barcelona, ISGlobal, C Doctor Aiguader 88, Barcelona 08003, Spain, Univ Pompeu Fabra, Placa Merce 10, Barcelona 08002, Spain, CIBER Epidemiol & Salud Publ CIBERESP, Ave Monforte de Lemos 3-5, Madrid, Spain. martine.vrijheid@isglobal.org-
local.publisher.placeMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr18739-
dc.source.typeArticle-
dc.identifier.doi10.1038/s41598-019-55283-8-
dc.identifier.pmid31822763-
dc.identifier.isiWOS:000502002400001-
dc.contributor.orcidSlama, Remy/0000-0002-8980-8529; lepeule, johanna/0000-0001-8907-197X;-
dc.contributor.orcidFossati, Serena/0000-0002-7484-5837; Tamayo Uria,-
dc.contributor.orcidIbon/0000-0002-8183-7106-
dc.identifier.eissn-
local.provider.typewosris-
local.uhasselt.uhpubyes-
item.validationecoom 2020-
item.fullcitationCLEMENTE BATALHA PARDAL, Diana; Maitre, Lea; Bustamante, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Grazuleviciene, Regina; Gutzkow, Kristine B.; Lepeule, Johanna; MARTENS, Dries; McEachan, Rosie R. C.; Meltzer, Helle M.; Petraviciene, Inga; Slama, Remy; Tamayo-Uria, Ibon; Urquiza, Jose; Vafeiadi, Marina; Wright, John; NAWROT, Tim & Vrijheid, Martine (2019) Obesity is associated with shorter telomeres in 8 year-old children. In: SCIENTIFIC REPORTS, 9 (1) (Art N° 18739).-
item.contributorCLEMENTE BATALHA PARDAL, Diana-
item.contributorMaitre, Lea-
item.contributorBustamante, Mariona-
item.contributorChatzi, Leda-
item.contributorRoumeliotaki, Theano-
item.contributorFossati, Serena-
item.contributorGrazuleviciene, Regina-
item.contributorGutzkow, Kristine B.-
item.contributorLepeule, Johanna-
item.contributorMARTENS, Dries-
item.contributorMcEachan, Rosie R. C.-
item.contributorMeltzer, Helle M.-
item.contributorPetraviciene, Inga-
item.contributorSlama, Remy-
item.contributorTamayo-Uria, Ibon-
item.contributorUrquiza, Jose-
item.contributorVafeiadi, Marina-
item.contributorWright, John-
item.contributorNAWROT, Tim-
item.contributorVrijheid, Martine-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
crisitem.journal.issn2045-2322-
crisitem.journal.eissn2045-2322-
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