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DC Field | Value | Language |
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dc.contributor.author | Vos, R. | - |
dc.contributor.author | Vanaudenaerde, B.M. | - |
dc.contributor.author | De Vleeschauwer, S.I. | - |
dc.contributor.author | WIDYASTUTI, Anna | - |
dc.contributor.author | Dupont, L.J. | - |
dc.contributor.author | Van Raemdonck, D.E. | - |
dc.contributor.author | Verleden, G.M. | - |
dc.date.accessioned | 2020-03-17T09:20:35Z | - |
dc.date.available | 2020-03-17T09:20:35Z | - |
dc.date.issued | 2009 | - |
dc.date.submitted | 2020-03-17T08:32:58Z | - |
dc.identifier.citation | Transplantation Proceedings, 41 (8) , p. 3409 -3413 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30812 | - |
dc.description.abstract | Background. C-reactive protein (CRP), an acute-phase marker of systemic inflammation, may also be a local regulator of the pulmonary immune system. Its role in lung transplantation (LT), however, is unclear. We hypothesized that CRP in bronchoalveolar lavage (BAL) fluid might be associated with airway inflammation or remodeling. Therefore, it could play a role in the development of bronchiolitis obliterans syndrome (BOS).Patients and Methods. A total of 100 LT recipients who had undergone transplantation between August 2001 and August 2005 were included in the current cross-sectional study. Patients who were evaluated at 90 days after LT were categorized as either stable (n = 36), colonized (n = 25), or suffering from infection (n = 16) or acute rejection (n = 23). BAL CRP, cell differentials, and interleukin (IL), IL8, transforming growth factor beta (TGF beta), and vascular endothelial growth factor (VEGF) protein levels, as well as blood leukocytosis, plasma CRP, and forced expiratory value in 1 second (FEV1; % predicted) were compared between groups. We analyzed the correlation of BAL CRP with inflammatory or remodeling markers and FEV1.Results. Compared with stable LT recipients, BAL CRP was significantly increased in patients with infection or acute rejection (P < .0001), but not in those with colonization. Generally, BAL CRP levels positively correlated with BAIL total cell count, neutrophilia, and IL8 levels, as well as with plasma CRP levels (P < .0001). An inverse correlation was observed with BAL macrophages (P < .01), VEGF (P < .0001), and FEV1 (P < .0001). Only a trend for a positive, respectively inverse correlation was seen for BAIL IL6 and TGF beta.Conclusions. The current data corroborate a possible role for CRP in airway inflammation after LT. Its importance for BOS should therefore be further elucidated. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.publisher | - | |
dc.rights | © 2009 by Elsevier Inc. All rights reserved. | - |
dc.subject.other | Bronchiolitis-Obliterans-Syndrome | - |
dc.subject.other | Systemic Inflammation | - |
dc.subject.other | Allograft-Rejection | - |
dc.subject.other | Elevated Levels | - |
dc.subject.other | Expression | - |
dc.subject.other | Tnf | - |
dc.title | C-Reactive Protein in Bronchoalveolar Lavage Fluid is Associated With Markers of Airway Inflammation After Lung Transplantation | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3413 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 3409 | - |
dc.identifier.volume | 41 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | journal-article | - |
dc.identifier.doi | 10.1016/j.transproceed.2009.09.029 | - |
dc.identifier.pmid | 19857759 | - |
dc.identifier.scopus | 2-s2.0-70350518921 | - |
dc.identifier.isi | WOS:000271546600113 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-70350518921&partnerID=MN8TOARS | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.contributor.orcid | #NODATA# | - |
dc.identifier.eissn | 1873-2623 | - |
local.provider.type | Orcid | - |
local.uhasselt.uhpub | no | - |
item.contributor | Vos, R. | - |
item.contributor | Vanaudenaerde, B.M. | - |
item.contributor | De Vleeschauwer, S.I. | - |
item.contributor | WIDYASTUTI, Anna | - |
item.contributor | Dupont, L.J. | - |
item.contributor | Van Raemdonck, D.E. | - |
item.contributor | Verleden, G.M. | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Vos, R.; Vanaudenaerde, B.M.; De Vleeschauwer, S.I.; WIDYASTUTI, Anna; Dupont, L.J.; Van Raemdonck, D.E. & Verleden, G.M. (2009) C-Reactive Protein in Bronchoalveolar Lavage Fluid is Associated With Markers of Airway Inflammation After Lung Transplantation. In: Transplantation Proceedings, 41 (8) , p. 3409 -3413. | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Research publications |
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C_reactive_Protein.pdf Restricted Access | Published version | 158.81 kB | Adobe PDF | View/Open Request a copy |
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