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http://hdl.handle.net/1942/30839
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DC Field | Value | Language |
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dc.contributor.author | Ono, Masafumi | - |
dc.contributor.author | Chichareon, Ply | - |
dc.contributor.author | Tomaniak, Mariusz | - |
dc.contributor.author | Kawashima, Hideyuki | - |
dc.contributor.author | Takahashi, Kuniaki | - |
dc.contributor.author | Kogame, Norihiro | - |
dc.contributor.author | Modolo, Rodrigo | - |
dc.contributor.author | Hara, Hironori | - |
dc.contributor.author | Gao, Chao | - |
dc.contributor.author | Wang, Rutao | - |
dc.contributor.author | Walsh, Simon | - |
dc.contributor.author | Suryapranata, Harry | - |
dc.contributor.author | da Silva, Pedro Canas | - |
dc.contributor.author | Cotton, James | - |
dc.contributor.author | Koning, Rene | - |
dc.contributor.author | Akin, Ibrahim | - |
dc.contributor.author | Rensing, Benno J. W. M. | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Wykrzykowska, Joanna J. | - |
dc.contributor.author | Piek, Jan J. | - |
dc.contributor.author | Juni, Peter | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Storey, Robert F. | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2020-03-19T09:27:56Z | - |
dc.date.available | 2020-03-19T09:27:56Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-17T10:59:55Z | - |
dc.identifier.citation | CLINICAL RESEARCH IN CARDIOLOGY, 109(9), p. 1125-1139 | - |
dc.identifier.issn | 1861-0684 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30839 | - |
dc.description.abstract | Background The efficacy of antiplatelet therapies following percutaneous coronary intervention (PCI) may be affected by body mass index (BMI). Methods and results This is a prespecified subgroup analysis of the GLOBAL LEADERS trial, a prospective, multicenter, open-label, randomized controlled trial in an all-comer population undergoing PCI, comparing the experimental strategy (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with a reference regimen (12-month aspirin monotherapy following 12-month DAPT). A total of 15,968 patients were stratified by baseline BMI with prespecified threshold of 27 kg/m2. Of those, 6973 (43.7%) patients with a BMI < 27 kg/m2 had a higher risk of all-cause mortality at 2 years than those with BMI = 27 kg/m2 (adjusted HR 1.24, 95% CI 1.02-1.49). At 2 years, the rates of the primary endpoint (all-cause mortality or new Q-wave myocardial infarction) were similar between treatment strategies in either BMI group (pinteraction = 0.51). In acute coronary syndrome, however, the experimental strategy was associated with significant reduction of the primary endpoint compared to the reference strategy in patients with BMI < 27 kg/m2 (HR 0.69, 95% CI 0.51-0.94), but not in the ones with BMI = 27 kg/m2 (pinteraction = 0.047). In chronic coronary syndrome, there was no between-group difference in the efficacy and safety of the two antiplatelet strategies. Conclusions Overall, BMI did not influence the treatment effect seen with ticagrelor monotherapy; however, a beneficial effect of ticagrelor monotherapy was seen in ACS patients with BMI < 27 kg/m(2). | - |
dc.description.sponsorship | GLOBAL LEADERS study was sponsored by the European Clinical Research. Institute, which received funding from Biosensors International, AstraZeneca and the Medicines Company. The study funders had no role in trial design; data collection, analysis or interpretation; or writing of the report. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | - |
dc.subject.other | Body mass index | - |
dc.subject.other | Percutaneous coronary intervention | - |
dc.subject.other | Drug-eluting stent | - |
dc.subject.other | Dual antiplatelet therapy | - |
dc.subject.other | Ticagrelor monotherapy | - |
dc.subject.other | Acute coronary syndrome | - |
dc.title | The association of body mass index with long‑term clinical outcomes after ticagrelor monotherapy following abbreviated dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a prespecifed sub‑analysis of the GLOBAL LEADERS Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1139 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1125 | - |
dc.identifier.volume | 109 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Serruys, PW (reprint author), NUIG Natl Univ Ireland, Dept Cardiol, Univ Rd, Galway H91 TK33, Ireland.; Serruys, PW (reprint author), Imperial Coll London, NHLI, London, England. | - |
dc.description.notes | patrick.w.j.c.serruys@gmail.com | - |
dc.description.other | Serruys, PW (reprint author), NUIG Natl Univ Ireland, Dept Cardiol, Univ Rd, Galway H91 TK33, Ireland; Imperial Coll London, NHLI, London, England. patrick.w.j.c.serruys@gmail.com | - |
local.publisher.place | TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1007/s00392-020-01604-1 | - |
dc.identifier.pmid | 32006156 | - |
dc.identifier.isi | WOS:000515718100002 | - |
dc.identifier.eissn | 1861-0692 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.accessRights | Open Access | - |
item.fullcitation | Ono, Masafumi; Chichareon, Ply; Tomaniak, Mariusz; Kawashima, Hideyuki; Takahashi, Kuniaki; Kogame, Norihiro; Modolo, Rodrigo; Hara, Hironori; Gao, Chao; Wang, Rutao; Walsh, Simon; Suryapranata, Harry; da Silva, Pedro Canas; Cotton, James; Koning, Rene; Akin, Ibrahim; Rensing, Benno J. W. M.; Garg, Scot; Wykrzykowska, Joanna J.; Piek, Jan J.; Juni, Peter; Hamm, Christian; Steg, Philippe Gabriel; Valgimigli, Marco; Windecker, Stephan; Storey, Robert F.; Onuma, Yoshinobu; VRANCKX, Pascal & Serruys, Patrick W. (2020) The association of body mass index with long‑term clinical outcomes after ticagrelor monotherapy following abbreviated dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a prespecifed sub‑analysis of the GLOBAL LEADERS Trial. In: CLINICAL RESEARCH IN CARDIOLOGY, 109(9), p. 1125-1139. | - |
item.contributor | Ono, Masafumi | - |
item.contributor | Chichareon, Ply | - |
item.contributor | Tomaniak, Mariusz | - |
item.contributor | Kawashima, Hideyuki | - |
item.contributor | Takahashi, Kuniaki | - |
item.contributor | Kogame, Norihiro | - |
item.contributor | Modolo, Rodrigo | - |
item.contributor | Hara, Hironori | - |
item.contributor | Gao, Chao | - |
item.contributor | Wang, Rutao | - |
item.contributor | Walsh, Simon | - |
item.contributor | Suryapranata, Harry | - |
item.contributor | da Silva, Pedro Canas | - |
item.contributor | Cotton, James | - |
item.contributor | Koning, Rene | - |
item.contributor | Akin, Ibrahim | - |
item.contributor | Rensing, Benno J. W. M. | - |
item.contributor | Garg, Scot | - |
item.contributor | Wykrzykowska, Joanna J. | - |
item.contributor | Piek, Jan J. | - |
item.contributor | Juni, Peter | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Storey, Robert F. | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Serruys, Patrick W. | - |
crisitem.journal.issn | 1861-0684 | - |
crisitem.journal.eissn | 1861-0692 | - |
Appears in Collections: | Research publications |
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