Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30880
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | GYSELAERS, Wilfried | - |
dc.contributor.author | Thilaganathan, Basky | - |
dc.date.accessioned | 2020-03-27T09:57:18Z | - |
dc.date.available | 2020-03-27T09:57:18Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-03-10T13:17:28Z | - |
dc.identifier.citation | JOURNAL OF PHYSIOLOGY-LONDON, 597 (18) , p. 4695 -4714 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30880 | - |
dc.description.abstract | It is generally accepted today that there are two different types of preeclampsia: an early-onset or placental type and a late-onset or maternal type. In the latent phase, the first one presents with a low output/high resistance circulation eventually leading in the late second or early third trimester to an intense and acutely aggravating systemic disorder with an important impact on maternal and neonatal mortality and morbidity; the other type presents initially as a high volume/low resistance circulation, gradually evolving to a state of circulatory decompensation usually in the later stages of pregnancy, with a less severe impact on maternal and neonatal outcome. For both processes, numerous dysfunctions of the heart, kidneys, arteries, veins and interconnecting systems are reported, most of them presenting earlier and more severely in early- than in late-onset preeclampsia; however, some very specific dysfunctions exist for either type. Experimental, clinical and epidemiological observations before, during and after pregnancy are consistent with gestation-induced worsening of subclinical pre-existing chronic cardiovascular dysfunction in early-onset preeclampsia, and thus sharing the pathophysiology of cardiorenal syndrome type II, and with acute volume overload decompensation of the maternal circulation in late-onset preeclampsia, thus sharing the pathophysiology of cardiorenal syndrome type 1. Cardiorenal syndrome type V is consistent with the process of preeclampsia superimposed upon clinical cardiovascular and/or renal disease, alone or as part of a systemic disorder. This review focuses on the specific differences in haemodynamic dysfunctions between the two types of preeclampsia, with special emphasis on the interorgan interactions between heart and kidneys, introducing the theoretical concept that the pathophysiological processes of preeclampsia can be regarded as the gestational manifestations of cardiorenal syndromes. | - |
dc.description.sponsorship | The authors acknowledge the numerous discussions within the meetings of the International Working Group on Maternal Hemodynamics, which have substantially contributed to the concept of this work. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2019 The Authors. The Journal of Physiology C 2019 The Physiological Society | - |
dc.subject.other | Preeclampsia | - |
dc.subject.other | Cardiorenal syndrome | - |
dc.subject.other | Early onset preeclampsia | - |
dc.subject.other | Late onset preeclampsia | - |
dc.subject.other | Maternal hemodynamics | - |
dc.title | Preeclampsia: a gestational cardiorenal syndrome | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4714 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | 4695 | - |
dc.identifier.volume | 597 | - |
local.format.pages | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Gyselaers, W (reprint author), Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Schiepse Bos 6, B-3600 Genk, Belgium.; Thilaganathan, B (reprint author), St Georges Univ Hosp NHS Fdn Trust, Fetal Med Unit, 4th Floor Lanesborough Wing,Blackshaw Rd, London SW17 0QT, England. | - |
dc.description.notes | wilfried.gyselaers@zol.be; basky@pobox.com | - |
dc.description.other | Gyselaers, W (reprint author), Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Schiepse Bos 6, B-3600 Genk, Belgium. Thilaganathan, B (reprint author), St Georges Univ Hosp NHS Fdn Trust, Fetal Med Unit, 4th Floor Lanesborough Wing,Blackshaw Rd, London SW17 0QT, England. wilfried.gyselaers@zol.be; basky@pobox.com | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.source.type | Review | - |
dc.identifier.doi | 10.1113/JP274893 | - |
dc.identifier.isi | WOS:000481096000001 | - |
dc.contributor.orcid | Gyselaers, Wilfried/0000-0002-5778-434X | - |
dc.identifier.eissn | - | |
dc.identifier.eissn | 1469-7793 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.accessRights | Restricted Access | - |
item.contributor | GYSELAERS, Wilfried | - |
item.contributor | Thilaganathan, Basky | - |
item.fullcitation | GYSELAERS, Wilfried & Thilaganathan, Basky (2019) Preeclampsia: a gestational cardiorenal syndrome. In: JOURNAL OF PHYSIOLOGY-LONDON, 597 (18) , p. 4695 -4714. | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0022-3751 | - |
crisitem.journal.eissn | 1469-7793 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
gyselaers.pdf Restricted Access | Published version | 1.23 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.