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http://hdl.handle.net/1942/30882
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DC Field | Value | Language |
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dc.contributor.author | Ter Maaten, Jozine M. | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | L'Hoyes, Wouter | - |
dc.contributor.author | Maass, Alexander H. | - |
dc.contributor.author | Damman, Kevin | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2020-03-27T16:17:26Z | - |
dc.date.available | 2020-03-27T16:17:26Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-01-28T14:43:52Z | - |
dc.identifier.citation | JOURNAL OF CARDIAC FAILURE, 25 (10) , p. 803 -811 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30882 | - |
dc.description.abstract | Introduction: Limited data are available concerning the effect of severe chronic kidney disease (CKD) on the response to cardiac resynchronization therapy (CRT) because these patients are commonly excluded from trials. Therefore, we aimed to assess the effect of CRT on renal function, reverse remodeling and outcome across all stages of CKD in a large patient population of recipients of CRT. Methods: We retrospectively evaluated 798 consecutive patients with heart failure who were undergoing CRT implantation between October 2008 and September 2016. Renal function data were available at baseline and at 6 months following CRT. Remodeling based on left ventricular end diastolic volume/left ventricular ejection fraction (LVESV/LVEF) and clinical outcome was assessed using a combined endpoint of all -cause mortality and hospitalization because of heart failure. Results: Median baseline estimated glomerular filtration rate was 62.8 (43.6-77.8) mL/min/1.73 m2. Of the patients, 33.6% were in CKD stage 3, 11.0% in stage 4 and 1.1% in stage 5. LVEF and LVESV improved across all CKD stages; however, patients with CKD stages 1 and 2 exhibited a greater degree of improvement in LVEF (median 15% vs 10%, P < 0.001) and LVESV (median 37.2% vs 29.9%, P < 0.001) compared to patients with CKD stages 3-5. Despite a greater degree of reverse remodeling in CKD stages 1 and 2, the most accurate cut-off of remodeling predicting good clinical outcome was lower for patients with CKD stage 3-5, respectively: 5.5% vs 9.5% (LVEF) and 6.67% vs 12.41% (LVESV). Conclusions: CRT results in reverse remodeling across all stages of CKD, although to a lesser extent in patients with renal dysfunction (CKD stage 3-5). However, patients with CKD derive benefit on outcome at a lesser degree of remodeling. | - |
dc.description.sponsorship | PM is supported by a doctoral fellowship by the Research Foundation Flanders (FWO; grant no. 1127917N). PM and WM are researchers for the Limburg Clinical Research Program UHasselt-ZOL-Jessa and supported by the Limburg Sterk Merk foundation, Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. AHM has received lecture fees from Livallova and Medtronic. JMtM, WLH, KD, and MD have nothing to disclose. | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS | - |
dc.rights | 2019 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Cardiac resynchronization therapy | - |
dc.subject.other | chronic kidney disease | - |
dc.subject.other | heart failure | - |
dc.subject.other | response | - |
dc.title | Response to Cardiac Resynchronization Therapy Across Chronic Kidney Disease Stages | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 811 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 803 | - |
dc.identifier.volume | 25 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mullens, W (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | wilfried.mullens@zol.be | - |
dc.description.other | Mullens, W (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. wilfried.mullens@zol.be | - |
local.publisher.place | CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1016/j.cardfail.2019.07.005 | - |
dc.identifier.pmid | 31323302 | - |
dc.identifier.isi | WOS:000495806200005 | - |
dc.contributor.orcid | Maass, Alexander/0000-0002-7936-360X | - |
dc.identifier.eissn | 1532-8414 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.contributor | Ter Maaten, Jozine M. | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | L'Hoyes, Wouter | - |
item.contributor | Maass, Alexander H. | - |
item.contributor | Damman, Kevin | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Ter Maaten, Jozine M.; MARTENS, Pieter; L'Hoyes, Wouter; Maass, Alexander H.; Damman, Kevin; DUPONT, Matthias & MULLENS, Wilfried (2019) Response to Cardiac Resynchronization Therapy Across Chronic Kidney Disease Stages. In: JOURNAL OF CARDIAC FAILURE, 25 (10) , p. 803 -811. | - |
crisitem.journal.issn | 1071-9164 | - |
crisitem.journal.eissn | 1532-8414 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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jozine.pdf Restricted Access | Published version | 558.97 kB | Adobe PDF | View/Open Request a copy |
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