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http://hdl.handle.net/1942/30885
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DC Field | Value | Language |
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dc.contributor.author | Adams, P. | - |
dc.contributor.author | Iserentant, G. | - |
dc.contributor.author | Servais, J-Y | - |
dc.contributor.author | Pannus, P. | - |
dc.contributor.author | Rutsaert, S. | - |
dc.contributor.author | Van Frankehuijsen, M. | - |
dc.contributor.author | De Wit, S. | - |
dc.contributor.author | Allard, S. D. | - |
dc.contributor.author | MESSIAEN, Peter | - |
dc.contributor.author | Moutschen, M. | - |
dc.contributor.author | Aerts, J. L. | - |
dc.contributor.author | Vandekerckhove, L. | - |
dc.contributor.author | Vanham, G. | - |
dc.contributor.author | Devaux, C. | - |
dc.date.accessioned | 2020-03-30T09:20:21Z | - |
dc.date.available | 2020-03-30T09:20:21Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-01-28T14:10:21Z | - |
dc.identifier.citation | HIV MEDICINE, 20 (S9) , p. 42 -43 (Art N° PS14/3) | - |
dc.identifier.issn | 1464-2662 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30885 | - |
dc.description.abstract | Purpose: Potent HIV-specific immune responses and a small latent viralreservoir are likely required to control viral replication during HIV-1 infection.Here we investigated the antiviral CD8 + T cell response of elite and viremic controllers (EC and VC) and antiretroviral therapy-(ART) suppressed patients atbaseline and after peptide stimulation.Method: Peripheral blood mononuclear cells of 58 patients were analyzed by18 color flow cytometry and IFN-c ELIspot at baseline and after 7 days ofin vitro HIV peptide stimulation (PTE GAG pool, NIH). Plasmas were analyzedfor IFN-c, CXCL-10, IL1-b, IL6, TNF-a, IL-18 concentrations. Cytometry datawas clustered using viSNE and analyzed by Boolean gating strategy to assessmultifunctional characteristics. Statistical comparison was executed withQluCore and Prism nonparametric statistics (Kruskal-Wallis test correcting formultiple comparison).Results: IL-18 in plasma and CD38 expression on CD4 + T cells weresignificantly lower in EC and ART patients with low reservoir than in VC(p<0.05). We observed a significant increase in IFN-y production at baselineand after 7 days of peptide stimulation (p<0.0005) while CD107a and Ki67expression were also significantly increased for ECs compared to ART patients(p<0.001).Detailed phenotyping revealed that CD8 + effector memory T cells which areIFN-c+, Ki67+, CD107abright, Perforinbrightand GrzB+significantly increased inEC (p<0.005) as compared to VC and ART patients. Similarly we observedcentral memory CD8 + T cells subsets with increased cytotoxic andpolyfunctional features in EC (p<0.005). Interestingly, CD8 + T cells subsetsexpressing CXCR5, a homing receptor for lymph node follicles, and cytotoxicmarkers were significantly increased in EC as well (p<0.005).Conclusion: Distinct functional subsets coexist during natural control of HIV-1 infection. Access to the B cell zone of lymph node follicles by cytotoxicCD8 + T cells might explain long-term control of the HIV reservoir. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | Free access. 2019 The Authors HIV Medicine 2019 British HIV Association, HIV Medicine, 20 (Suppl. 9), 3–316 | - |
dc.title | Increased frequency of cytotoxic CXCR5+effector memory CD8+T cells during natural control of HIV-1 infection | - |
dc.type | Journal Contribution | - |
local.bibliographicCitation.conferencedate | 6‐9 November 2019 | - |
local.bibliographicCitation.conferencename | The 17th European AIDS Conference | - |
local.bibliographicCitation.conferenceplace | Basel, Switzerland | - |
dc.identifier.epage | 43 | - |
dc.identifier.issue | S9 | - |
dc.identifier.spage | 42 | - |
dc.identifier.volume | 20 | - |
local.format.pages | 2 | - |
local.bibliographicCitation.jcat | M | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
local.bibliographicCitation.artnr | PS14/3 | - |
dc.identifier.doi | 10.1111/hiv.12814 | - |
dc.identifier.isi | WOS:000494690300075 | - |
dc.identifier.eissn | 1468-1293 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.fullcitation | Adams, P.; Iserentant, G.; Servais, J-Y; Pannus, P.; Rutsaert, S.; Van Frankehuijsen, M.; De Wit, S.; Allard, S. D.; MESSIAEN, Peter; Moutschen, M.; Aerts, J. L.; Vandekerckhove, L.; Vanham, G. & Devaux, C. (2019) Increased frequency of cytotoxic CXCR5+effector memory CD8+T cells during natural control of HIV-1 infection. In: HIV MEDICINE, 20 (S9) , p. 42 -43 (Art N° PS14/3). | - |
item.contributor | Adams, P. | - |
item.contributor | Iserentant, G. | - |
item.contributor | Servais, J-Y | - |
item.contributor | Pannus, P. | - |
item.contributor | Rutsaert, S. | - |
item.contributor | Van Frankehuijsen, M. | - |
item.contributor | De Wit, S. | - |
item.contributor | Allard, S. D. | - |
item.contributor | MESSIAEN, Peter | - |
item.contributor | Moutschen, M. | - |
item.contributor | Aerts, J. L. | - |
item.contributor | Vandekerckhove, L. | - |
item.contributor | Vanham, G. | - |
item.contributor | Devaux, C. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1464-2662 | - |
crisitem.journal.eissn | 1468-1293 | - |
Appears in Collections: | Research publications |
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Adams_P.pdf | Published version | 206.2 kB | Adobe PDF | View/Open |
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