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http://hdl.handle.net/1942/30892
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DC Field | Value | Language |
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dc.contributor.author | Arrigo, Mattia | - |
dc.contributor.author | Jessup, Mariell | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | Reza, Nosheen | - |
dc.contributor.author | Shah, Ajay M. | - |
dc.contributor.author | Sliwa, Karen | - |
dc.contributor.author | Mebazaa, Alexandre | - |
dc.date.accessioned | 2020-03-30T14:09:41Z | - |
dc.date.available | 2020-03-30T14:09:41Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-30T11:58:48Z | - |
dc.identifier.citation | Nature Reviews Disease Primers, 6 (1) (Art N° 16) | - |
dc.identifier.uri | http://hdl.handle.net/1942/30892 | - |
dc.description.abstract | Acute heart failure (AHF) is a syndrome characterized by signs and symptoms of heart failure (typically systemic congestion) that occurs in the presence of an underlying cardiac dysfunction (previously diagnosed, undiagnosed or new-onset) and precipitating factors. AHF is associated with high mortality and hospital readmission rates. Acute heart failure (AHF) is a syndrome defined as the new onset (de novo heart failure (HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of HF, mostly related to systemic congestion. In the presence of an underlying structural or functional cardiac dysfunction (whether chronic in ADHF or undiagnosed in de novo HF), one or more precipitating factors can induce AHF, although sometimes de novo HF can result directly from the onset of a new cardiac dysfunction, most frequently an acute coronary syndrome. Despite leading to similar clinical presentations, the underlying cardiac disease and precipitating factors may vary greatly and, therefore, the pathophysiology of AHF is highly heterogeneous. Left ventricular diastolic or systolic dysfunction results in increased preload and afterload, which in turn lead to pulmonary congestion. Fluid retention and redistribution result in systemic congestion, eventually causing organ dysfunction due to hypoperfusion. Current treatment of AHF is mostly symptomatic, centred on decongestive drugs, at best tailored according to the initial haemodynamic status with little regard to the underlying pathophysiological particularities. As a consequence, AHF is still associated with high mortality and hospital readmission rates. There is an unmet need for increased individualization of in-hospital management, including treatments targeting the causative factors, and continuation of treatment after hospital discharge to improve long-term outcomes. | - |
dc.description.sponsorship | N.R. is supported by the National Institutes of Health, National Human Genome Research Institute, Ruth L. Kirschstein Institutional National Research Service T32 Award in Genomic Medicine (T32 HG009495). | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.rights | Springer Nature Limited 2020 | - |
dc.subject.other | In-Hospital Mortality | - |
dc.subject.other | Acute Myocardial-Infarction | - |
dc.subject.other | Reduced Ejection Fraction | - |
dc.subject.other | 2013 Accf/Aha Guideline | - |
dc.subject.other | Natriuretic Peptide | - |
dc.subject.other | European-Society | - |
dc.subject.other | Precipitating Factors | - |
dc.subject.other | Pulmonary Congestion | - |
dc.subject.other | Volume Expansion | - |
dc.subject.other | Lung Ultrasound | - |
dc.title | Acute heart failure | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 6 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Mebazaa, A (reprint author), Univ Paris, INSERM, MASCOT, Paris, France.; Mebazaa, A (reprint author), Hop Lariboisiere, AP HP, Dept Anesthesia Burn & Crit Care Med, Paris, France. | - |
dc.description.notes | alexandre.mebazaa@aphp.fr | - |
dc.description.other | Mebazaa, A, (reprint author), Univ Parirs, INSERM, MASCOT, Paris, France; Hop Lariboisiere, AP HP, Dept Anesthesia Burn & Crit Care Med, Paris, France. alexandre.mebazaa@aphp.fr | - |
local.publisher.place | MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 16 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1038/s41572-020-0151-7 | - |
dc.identifier.pmid | 32139695 | - |
dc.identifier.isi | WOS:000519016800001 | - |
dc.contributor.orcid | Arrigo, Mattia/0000-0003-4028-2869 | - |
dc.identifier.eissn | 2056-676X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fullcitation | Arrigo, Mattia; Jessup, Mariell; MULLENS, Wilfried; Reza, Nosheen; Shah, Ajay M.; Sliwa, Karen & Mebazaa, Alexandre (2020) Acute heart failure. In: Nature Reviews Disease Primers, 6 (1) (Art N° 16). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.accessRights | Open Access | - |
item.contributor | Arrigo, Mattia | - |
item.contributor | Jessup, Mariell | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | Reza, Nosheen | - |
item.contributor | Shah, Ajay M. | - |
item.contributor | Sliwa, Karen | - |
item.contributor | Mebazaa, Alexandre | - |
crisitem.journal.issn | 2056-676X | - |
crisitem.journal.eissn | 2056-676X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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arrigo.pdf | Published version | 1.63 MB | Adobe PDF | View/Open |
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