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http://hdl.handle.net/1942/30895
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DC Field | Value | Language |
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dc.contributor.author | RAMAEKERS, Jeroen | - |
dc.contributor.author | Janssens, Joyce | - |
dc.contributor.author | Waumans, Lise | - |
dc.contributor.author | Stessens, Linde | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | MARTENS, Pieter | - |
dc.date.accessioned | 2020-03-30T14:39:02Z | - |
dc.date.available | 2020-03-30T14:39:02Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-30T11:51:48Z | - |
dc.identifier.citation | ACTA CARDIOLOGICA, 75 (2) , p. 138 -146 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30895 | - |
dc.description.abstract | Background: Endomyocardial biopsies (EMBs) remain the golden standard to diagnose underlying pathophysiologic process in heart failure (HF), when potential therapeutic decisions cannot be made by non-invasive techniques. However, changes in the field of non-invasive diagnostic testing might have an impact on the need for performing an EMB in certain scenarios. Methods: We performed a retrospective analysis of consecutive EMBs performed in a single, non-academic, tertiary-care centre. EMBs were performed between February 2009 and March 2018. Baseline characteristics including non-invasive imaging and hemodynamic profile were assessed. Indications of EMBs were analysed in accordance with the 2007-AHA/ACC/ESC-scientific statement on EMBs. Results: A total of 57 patients (74% male) were included. The overall diagnostic yield was 58%, with a trend towards a higher yield in left-side (64%) versus right-side EMBs (45%; p = .346). The majority of patients (88%) underwent EMBs for a class IIa-recommendation, 9% for a class-I recommendation and the remaining patients for a class IIb-indication. Of the EMBs for a class IIa indication, 82% (n = 47) was for an unexplained restrictive cardiomyopathy, in which 53% (n = 25) revealed a diagnosis (of whom n = 23 patients had amyloidosis). Subtyping of the EMBs with a pathologic diagnosis of amyloidosis revealed that 52% (n = 12) had transthyretin amyloidosis (ATTR) and 43% (n = 10) had light-chain amyloidosis (AL). Overall one major (1.7%) and one minor (1.7%) complication occurred following the EMB-procedure. Conclusions: When following the AHA/ACC/ESC-scientific statement on EMBs, the performance of EMBs had a high diagnostic yield, with acceptable complication rates. However, in patients presenting with an unexplained restricted cardiomyopathy, technetium-labelled bone scanning could offer a non-invasive approach to establishing the diagnosis of ATTR, mitigating the need for EMBs in a subset of patients. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.rights | 2020 Informa UK Limited. | - |
dc.subject.other | Heart failure | - |
dc.subject.other | endomyocardial biopsy | - |
dc.subject.other | amyloidosis | - |
dc.subject.other | cardiovascular surgery | - |
dc.subject.other | diagnostic yield | - |
dc.title | Indications and diagnostic yield of endomyocardial biopsies for unexplained cardiomyopathy, a single center experience | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 146 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 138 | - |
dc.identifier.volume | 75 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Martens, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | pieter.martens2@zol.be | - |
dc.description.other | Martens, P (reprint author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. pieter.martens2@zol.be | - |
local.publisher.place | 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1080/00015385.2018.1561597 | - |
dc.identifier.pmid | 30650043 | - |
dc.identifier.isi | WOS:000518500300006 | - |
dc.contributor.orcid | Ramaekers, Jobbe/0000-0001-9065-0696 | - |
dc.identifier.eissn | 1784-973X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.fullcitation | RAMAEKERS, Jeroen; Janssens, Joyce; Waumans, Lise; Stessens, Linde; DUPONT, Matthias; MULLENS, Wilfried & MARTENS, Pieter (2020) Indications and diagnostic yield of endomyocardial biopsies for unexplained cardiomyopathy, a single center experience. In: ACTA CARDIOLOGICA, 75 (2) , p. 138 -146. | - |
item.accessRights | Restricted Access | - |
item.contributor | RAMAEKERS, Jeroen | - |
item.contributor | Janssens, Joyce | - |
item.contributor | Waumans, Lise | - |
item.contributor | Stessens, Linde | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | MARTENS, Pieter | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0001-5385 | - |
crisitem.journal.eissn | 1784-973X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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jobbe.pdf Restricted Access | Published version | 1.36 MB | Adobe PDF | View/Open Request a copy |
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