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http://hdl.handle.net/1942/30910
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DC Field | Value | Language |
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dc.contributor.author | EVERSON, Frans | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Goswami, Nandu | - |
dc.contributor.author | Mthethwa, Mashudu | - |
dc.contributor.author | Webster, Ingrid | - |
dc.contributor.author | Mashele, Nyiko | - |
dc.contributor.author | Charania, Sana | - |
dc.contributor.author | Kamau, Festus | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | Strijdom, Hans | - |
dc.date.accessioned | 2020-04-02T09:13:52Z | - |
dc.date.available | 2020-04-02T09:13:52Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-03-25T09:26:33Z | - |
dc.identifier.citation | ENVIRONMENTAL RESEARCH, 182 (Art N° 108993) | - |
dc.identifier.issn | 0013-9351 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30910 | - |
dc.description.abstract | Air pollution exposure is a major global health concern and has been associated with molecular aging. Unfortunately, the situation has not received much attention in the African region. The aim of this study was to investigate whether current personal ambient NO 2 and benzene, toluene, ethyl-benzene and xylenes (ortho (o)-, meta (m)-and para (p)-xylene (BTEX) exposure is associated with leukocyte telomere length (LTL), a marker of molecular ageing, in apparently healthy women (mean ± SD age: 42.5 ± 13.4 years) residing in the Cape Town region of South Africa. The repeated measures study collected data from 61 women. Seven-day median (interquartile range (IQR)) personal NO 2 and BTEX exposure levels were determined via compact passive diffusion samplers carried on the person prior to baseline (NO 2 : 14.2 (9.4-17.2) μg/m³; Benzene: 3.1 (2.1-5.3) μg/ m³) and 6-month follow-up (NO 2 : 10.6 (6.6-13.6) μg/m³; Benzene: 2.2 (1.3-4.9) μg/m³) visits. LTL was measured at baseline and follow-up using a real-time PCR method. Multiple linear mixed model analyses (adjusting for age, body mass index, smoking, employment status, level of education and assessment visit) showed that each IQR increment increase in NO 2 (7.0 μg/m³) and benzene (3.3 μg/m³) was associated with −7.30% (95% CI: −10.98 to −3.46%; p < 0.001) and −6.78% (95% CI: −11.88 to −1.39%; p = 0.015) difference in LTL, respectively. The magnitude of these effects of NO 2 and benzene corresponds to the effect of an increase of 10.3-and 6.0-year in chronological age on LTL. Our study shows that personal exposures to NO 2 and benzene are associated with molecular ageing as indicated by LTL in healthy women residing in the Cape Town region. | - |
dc.description.sponsorship | The work was supported by the ERAfrica program of the EU 7th Framework Program (Grant number: IC-003), Department of Science and Technology in South Africa (Grant number: DST/CON 0077/2014), The Belgian Science Policy in Belgium (Grant number BL/67/eranet03), and the Österreichische Agentur für internationale Mobilität und Kooperation in Bildung, Wissenschaft und Forschung, OeAD GmbH (ÖAD) in Austria (Grant number: KEF-Projekt P202). In addition, Frans Everson received a grant from Hasselt University in the context of BILA (bilateral) collaboration with Stellenbosch University (BOF16BL05). | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | 2019 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Air pollution | - |
dc.subject.other | Nitrogen dioxide | - |
dc.subject.other | Benzene | - |
dc.subject.other | Leukocyte telomere length | - |
dc.subject.other | South Africa | - |
dc.title | Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 182 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 108993 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1016/j.envres.2019.108993 | - |
dc.identifier.pmid | 31830692 | - |
dc.identifier.isi | WOS:000516094400067 | - |
dc.identifier.eissn | 1096-0953 | - |
local.provider.type | - | |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.accessRights | Restricted Access | - |
item.fullcitation | EVERSON, Frans; MARTENS, Dries; NAWROT, Tim; Goswami, Nandu; Mthethwa, Mashudu; Webster, Ingrid; Mashele, Nyiko; Charania, Sana; Kamau, Festus; DE BOEVER, Patrick & Strijdom, Hans (2020) Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women. In: ENVIRONMENTAL RESEARCH, 182 (Art N° 108993). | - |
item.validation | ecoom 2021 | - |
item.contributor | EVERSON, Frans | - |
item.contributor | MARTENS, Dries | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Goswami, Nandu | - |
item.contributor | Mthethwa, Mashudu | - |
item.contributor | Webster, Ingrid | - |
item.contributor | Mashele, Nyiko | - |
item.contributor | Charania, Sana | - |
item.contributor | Kamau, Festus | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | Strijdom, Hans | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0013-9351 | - |
crisitem.journal.eissn | 1096-0953 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Everson2019Telomere.pdf Restricted Access | Published version | 333.29 kB | Adobe PDF | View/Open Request a copy |
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