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http://hdl.handle.net/1942/31148
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DC Field | Value | Language |
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dc.contributor.author | Heymans, Cathelijne | - |
dc.contributor.author | de Lange, Ilse H. | - |
dc.contributor.author | Hutten, Matthias C. | - |
dc.contributor.author | Lenaerts, Kaatje | - |
dc.contributor.author | de Ruijter, Nadine J. E. | - |
dc.contributor.author | Kessels, Lilian C. G. A. | - |
dc.contributor.author | Rademakers, Glenn | - |
dc.contributor.author | Melotte, Veerle | - |
dc.contributor.author | BOESMANS, Werend | - |
dc.contributor.author | Saito, Masatoshi | - |
dc.contributor.author | Usuda, Haruo | - |
dc.contributor.author | Stock, Sarah J. | - |
dc.contributor.author | Spiller, Owen B. | - |
dc.contributor.author | Payne, Matthew S. | - |
dc.contributor.author | Kramer, Boris W. | - |
dc.contributor.author | Newnham, John P. | - |
dc.contributor.author | Jobe, Alan H. | - |
dc.contributor.author | Kemp, Matthew W. | - |
dc.contributor.author | van Gemert, Wim G. | - |
dc.contributor.author | Wolfs, Tim G. A. M. | - |
dc.date.accessioned | 2020-05-19T13:38:36Z | - |
dc.date.available | 2020-05-19T13:38:36Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-05-19T12:54:02Z | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, 11 (Art N° 189) | - |
dc.identifier.uri | http://hdl.handle.net/1942/31148 | - |
dc.description.abstract | Background: Chorioamnionitis, inflammation of the fetal membranes during pregnancy, is often caused by intra-amniotic (IA) infection with single or multiple microbes. Chorioamnionitis can be either acute or chronic and is associated with adverse postnatal outcomes of the intestine, including necrotizing enterocolitis (NEC). Neonates with NEC have structural and functional damage to the intestinal mucosa and the enteric nervous system (ENS), with loss of enteric neurons and glial cells. Yet, the impact of acute, chronic, or repetitive antenatal inflammatory stimuli on the development of the intestinal mucosa and ENS has not been studied. The aim of this study was therefore to investigate the effect of acute, chronic, and repetitive microbial exposure on the intestinal mucosa, submucosa and ENS in premature lambs. Materials and Methods: A sheep model of pregnancy was used in which the ileal mucosa, submucosa, and ENS were assessed following IA exposure to lipopolysaccharide (LPS) for 2 or 7 days (acute), Ureaplasma parvum (UP) for 42 days (chronic), or repetitive microbial exposure (42 days UP with 2 or 7 days LPS). Results: IA LPS exposure for 7 days or IA UP exposure for 42 days caused intestinal injury and inflammation in the mucosal and submucosal layers of the gut. Repetitive microbial exposure did not further aggravate injury of the terminal ileum. Chronic IA UP exposure caused significant structural ENS alterations characterized by loss of PGP9.5 and S100 beta immunoreactivity, whereas these changes were not found after re-exposure of chronic UP-exposed fetuses to LPS for 2 or 7 days. Conclusion: The in utero loss of PGP9.5 and S100 beta immunoreactivity following chronic UP exposure corresponds with intestinal changes in neonates with NEC and may therefore form a novel mechanistic explanation for the association of chorioamnionitis and NEC. | - |
dc.description.sponsorship | This work was supported by the National Institutes of Health (Bethesda, MD, USA) grant (HD 57869) and the Kinderonderzoekfonds Limburg (TW). | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | 2020 Heymans, de Lange, Hütten, Lenaerts, de Ruijter, Kessels, Rademakers, Melotte, Boesmans, Saito, Usuda, Stock, Spiller, Beeton, Payne, Kramer, Newnham, Jobe, Kemp, van Gemert and Wolfs. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | Ureaplasma parvum | - |
dc.subject.other | intra-amniotic infection | - |
dc.subject.other | chorioamnionitis | - |
dc.subject.other | enteric nervous system | - |
dc.subject.other | sheep | - |
dc.subject.other | preterm birth | - |
dc.subject.other | necrotizing enterocolitis | - |
dc.title | Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Wolfs, TGAM (reprint author), Maastricht Univ, Sch Oncol & Dev Biol Grow, Dept Pediat, Maastricht, Netherlands.; Wolfs, TGAM (reprint author), Maastricht Univ, Sch Cardiovasc Dis CARIM, Dept Biomed Engn BMT, Maastricht, Netherlands. | - |
dc.description.notes | tim.wolfs@maastrichiuniversity.nl | - |
dc.description.other | Wolfs, TGAM (reprint author), Maastricht Univ, Sch Oncol & Dev Biol Grow, Dept Pediat, Maastricht, Netherlands; Maastricht Univ, Sch Cardiovasc Dis CARIM, Dept Biomed Engn BMT, Maastricht, Netherlands. tim.wolfs@maastrichiuniversity.nl | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 189 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.3389/fimmu.2020.00189 | - |
dc.identifier.pmid | 32256485 | - |
dc.identifier.isi | WOS:000525669500001 | - |
dc.contributor.orcid | Heymans, Cathelijne/0000-0001-9373-1360; Wolfs, Tim/0000-0003-4417-4144; | - |
dc.contributor.orcid | Spiller, Brad/0000-0002-9117-6911 | - |
dc.identifier.eissn | - | |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fullcitation | Heymans, Cathelijne; de Lange, Ilse H.; Hutten, Matthias C.; Lenaerts, Kaatje; de Ruijter, Nadine J. E.; Kessels, Lilian C. G. A.; Rademakers, Glenn; Melotte, Veerle; BOESMANS, Werend; Saito, Masatoshi; Usuda, Haruo; Stock, Sarah J.; Spiller, Owen B.; Payne, Matthew S.; Kramer, Boris W.; Newnham, John P.; Jobe, Alan H.; Kemp, Matthew W.; van Gemert, Wim G. & Wolfs, Tim G. A. M. (2020) Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses. In: FRONTIERS IN IMMUNOLOGY, 11 (Art N° 189). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | Heymans, Cathelijne | - |
item.contributor | de Lange, Ilse H. | - |
item.contributor | Hutten, Matthias C. | - |
item.contributor | Lenaerts, Kaatje | - |
item.contributor | de Ruijter, Nadine J. E. | - |
item.contributor | Kessels, Lilian C. G. A. | - |
item.contributor | Rademakers, Glenn | - |
item.contributor | Melotte, Veerle | - |
item.contributor | BOESMANS, Werend | - |
item.contributor | Saito, Masatoshi | - |
item.contributor | Usuda, Haruo | - |
item.contributor | Stock, Sarah J. | - |
item.contributor | Spiller, Owen B. | - |
item.contributor | Payne, Matthew S. | - |
item.contributor | Kramer, Boris W. | - |
item.contributor | Newnham, John P. | - |
item.contributor | Jobe, Alan H. | - |
item.contributor | Kemp, Matthew W. | - |
item.contributor | van Gemert, Wim G. | - |
item.contributor | Wolfs, Tim G. A. M. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 1664-3224 | - |
crisitem.journal.eissn | 1664-3224 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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fimmu-11-00189.pdf | Published version | 5.21 MB | Adobe PDF | View/Open |
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