Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/31175
Title: | The use of pulse-echo ultrasound in women with a recent non-vertebral fracture to identify those without osteoporosis and/or a subclinical vertebral fracture: a pilot study | Authors: | van den Berg, Peter Schweitzer, Dave H. van Haard, Paul M. M. GEUSENS, Piet VAN DEN BERGH, Joop |
Issue Date: | 2020 | Publisher: | SPRINGER LONDON LTD | Source: | ARCHIVES OF OSTEOPOROSIS, 15 (1) (Art N° 56) | Abstract: | A Summary A pilot study on the use of P-EU to identify patients without osteoporosis and/or a subclinical vertebral fracture after a recently sustained non-vertebral fracture (NVF). Introduction Screening with portable devices at emergency departments or plaster rooms could be of interest to limit referrals for dual X-ray absorptiometry (DXA) and vertebral fracture assessment (VFA). We calculated the number of negative tests for osteoporosis and/or subclinical vertebral fractures (VFs) using pulse-echo ultrasonometry (P-UE) at different thresholds. Patients and methods In this cross-sectional study, 209 consecutive women of 50-70 years with a recent non-vertebral fracture (NVF) were studied at the Fracture Liaison Service (FLS) of one hospital. All women received DXA/VFA and P-EU (Bindex (R)) assessments. Various P-EU thresholds (based on the density index (DI, g/cm(2))) were analyzed to calculate the best balance between true negative (indeed no osteoporosis and/or subclinical VF) and false negative tests (osteoporosis and/or subclinical VF according to DXA/VFA). Results Eighty-three women had osteoporosis (40%) and 17 women at least one VF (8%). Applying the manufacturer's recommended P-EU threshold (DI 0.844 g/cm(2)) being their proposed cut-off for not having hip osteoporosis resulted in 77 negative tests (37%, 31% true negative and 6% false negative tests). A DI of 0.896 g/cm(2) resulted in 40 negative tests (19.3%) (38 true negative (18.3%) and 2 false negative tests (1.0%)). Conclusion The application of P-EU enables the identification of a substantial proportion of women with recent non-vertebral fractures at the FLS who would not need a DXA/VFA referral because they had no osteoporosis and/or subclinical vertebral fractures. The most conservative P-EU threshold resulted in 18.3% true negative tests verified by DXA/VFA against 1% false negative test results. | Notes: | van den Berg, P (reprint author), Reiner Graaf Gasthuis, Dept Orthoped & Surg, Fracture Liaison Serv, Delft, Netherlands. pberg@rdgg.nl |
Other: | van den Berg, P (reprint author), Reiner Graaf Gasthuis, Dept Orthoped & Surg, Fracture Liaison Serv, Delft, Netherlands. pberg@rdgg.nl | Keywords: | DXA/VFA;FLS;Non-vertebral fracture;Osteoporosis;Subclinical vertebral fracture;Pulse-echo ultrasound | Document URI: | http://hdl.handle.net/1942/31175 | ISSN: | 1862-3522 | e-ISSN: | 1862-3514 | DOI: | 10.1007/s11657-020-00730-7 | ISI #: | WOS:000525760900001 | Rights: | International Osteoporosis Foundation and National Osteoporosis Foundation 2020. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
peter.pdf Restricted Access | Published version | 421.14 kB | Adobe PDF | View/Open Request a copy |
WEB OF SCIENCETM
Citations
5
checked on Oct 13, 2024
Page view(s)
28
checked on Sep 7, 2022
Download(s)
8
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.