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Title: | Usefulness of the updated logistic clinical SYNTAX score after percutaneous coronary intervention in patients with prior coronary artery bypass graft surgery: Insights from the GLOBAL LEADERS trial | Authors: | Hara, Hironori Kogame, Norihiro Takahashi, Kuniaki Modolo, Rodrigo Chichareon, Ply Tomaniak, Mariusz Ono, Masafumi Kawashima, Hideyuki Gao, Chao Wang, Rutao Valkov, Veselin D. vom Dahl, Juergen Steinwender, Clemens Geisler, Tobias Lemos Neto, Pedro Alves Miguel, Carlos Macaya Garg, Scot Juni, Peter Hamm, Christian Steg, Philippe Gabriel Valgimigli, Marco VRANCKX, Pascal Windecker, Stephan Farooq, Vasim Onuma, Yoshinobu Serruys, Patrick W. |
Issue Date: | 2020 | Publisher: | WILEY | Source: | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 96(5), p. E516-E526 | Abstract: | Objectives We aimed to investigate the prognostic utility of the anatomical CABG SYNTAX and logistic clinical SYNTAX scores for mortality after percutaneous coronary intervention (PCI) in patients with prior coronary artery bypass grafts (CABG). Background The anatomical SYNTAX score evaluated the anatomical complexity of coronary artery disease and helped predict the prognosis of patients undergoing PCI. The anatomical CABG SYNTAX score was derived from the anatomical SYNTAX score in patients with prior CABG, whilst the logistic clinical SYNTAX score was developed by incorporating clinical factors into the anatomical SYNTAX score. Methods We calculated the anatomical CABG SYNTAX score and logistic clinical SYNTAX score in 205 patients in the GLOBAL LEADERS trial. The predictive abilities of these scores for 2-year all-cause mortality were evaluated. Results Using the median scores as categorical thresholds between low and high score groups, the logistic clinical SYNTAX score was able to discriminate the risk of 2-year mortality, unlike the anatomical CABG SYNTAX score. The logistic clinical SYNTAX was significantly better at predicting 2-year mortality, compared to the anatomical CABG SYNTAX score, as evidenced by AUC values in receiver-operating characteristic curve analysis (0.806 vs. 0.582, p < .001) and integrated discrimination improvement (0.121, p < .001). Conclusions The logistic clinical SYNTAX score was superior to the anatomical CABG SYNTAX score in predicting 2-year mortality. | Notes: | Serruys, PW (reprint author), NUIG, Intervent Med & Innovat, Univ Rd, Galway H91 TK33, Ireland. patrick.w.j.c.serruys@gmail.com |
Other: | Serruys, PW (reprint author), NUIG, Intervent Med & Innovat, Univ Rd, Galway H91 TK33, Ireland. patrick.w.j.c.serruys@gmail.com | Keywords: | coronary bypass grafts;drug eluting;percutaneous coronary intervention (PCI);risk stratification;stent | Document URI: | http://hdl.handle.net/1942/31177 | ISSN: | 1522-1946 | e-ISSN: | 1522-726X | DOI: | 10.1002/ccd.28898 | ISI #: | WOS:000525765100001 | Rights: | 2020 Wiley Periodicals, Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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Cathet Cardio Intervent.pdf Restricted Access | Published version | 2.39 MB | Adobe PDF | View/Open Request a copy |
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