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Title: | The Efficacy, Safety and Tolerability of Canakinumab in the Treatment of Familial Mediterranean Fever: A Systematic Review of the Literature | Authors: | Kacar, Mark Savic, Sinisa VAN DER HILST, Jeroen |
Issue Date: | 2020 | Publisher: | DOVE MEDICAL PRESS LTD | Source: | JOURNAL OF INFLAMMATION RESEARCH, 13 , p. 141 -149 | Abstract: | Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%-10% of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchicine in doses needed to prevent attacks. For these patients, Canakinumab, a full human antibody against IL-1 beta, has been approved recently by the FDA and EMA. In this article, we present a systematic review of the long-term efficacy, safety, and tolerability of Canakinumab in FMF patients who cannot tolerate colchicine or who are resistant to colchicine treatment. | Notes: | van der Hilst, JCH (reprint author), Jessa Hosp, Dept Infect Dis & Immun, Stadsomvaart 11, B-3500 Hasselt, Belgium. jeroen.vanderhilst@jessazh.be |
Other: | van der Hilst, JCH (reprint author), Jessa Hosp, Dept Infect Dis & Immun, Stadsomvaart 11, B-3500 Hasselt, Belgium. jeroen.vanderhilst@jessazh.be | Keywords: | familial mediterranean fever;Canakinumab;anti-IL1 therapy | Document URI: | http://hdl.handle.net/1942/31221 | e-ISSN: | 1178-7031 | DOI: | 10.2147/JIR.S206204 | ISI #: | WOS:000520589800001 | Rights: | 2020 Kacar et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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