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http://hdl.handle.net/1942/31222
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DC Field | Value | Language |
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dc.contributor.author | Belostotskaya, Galina | - |
dc.contributor.author | HENDRIKX, Marc | - |
dc.contributor.author | Galagudza, Michael | - |
dc.contributor.author | Suchkov, Sergey | - |
dc.date.accessioned | 2020-05-26T14:21:56Z | - |
dc.date.available | 2020-05-26T14:21:56Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-05-04T11:02:48Z | - |
dc.identifier.citation | BIOMED RESEARCH INTERNATIONAL, 2020 (Art N° 7874109) | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31222 | - |
dc.description.abstract | Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been conclusively demonstrated. Consequently, the focus of research in the field has since shifted to stem cell-derived paracrine factors, including cytokines, growth factors, mRNA, and miRNA. Notably, both mRNA and miRNA can enter into the extracellular space either in soluble form or packed into membrane vesicles. Stem cell-derived paracrine factors have been shown to suppress inflammation and apoptosis, stimulate angiogenesis, and amplify the proliferation and differentiation of resident cardiac stem cells (CSCs). Such features have led to exosomes being considered as potential drug candidates affording myocardial regeneration. The search for chemical signals capable of stimulating cardiomyogenesis is ongoing despite continuous debates regarding the ability of mature cardiomyocytes to divide or dedifferentiate, transdifferentiation of other cells into cardiomyocytes, and the ability of CSCs to differentiate into cardiomyocytes. Future research is aimed at identifying novel cell candidates capable of differentiating into cardiomyocytes. The observation that CSCs can undergo intracellular development with the formation of "cell-in-cell structure" and subsequent release of transitory amplifying cells with the capacity to differentiate into cardiomyocytes may provide clues for stimulating regenerative cardiomyogenesis. | - |
dc.description.sponsorship | This work was supported by the grants from the Russian Foundation for Basic Research (Nos. 12-04-00941 and 16-04-01424) and Program of Presidium of Russian Academy of Sciences "Fundamental Sciences for Medicine" (2012-2014), by the state assignment of FASO of Russia ("The mechanisms of development of neuropsychic, metabolic, and hormonal dysfunctions in the nervous and endocrine diseases and the approaches for their correction"), and by the Government of Russian Federation, Grant 08-08. | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.rights | 2020 Galina Belostotskaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.title | How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 2020 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Belostotskaya, G (reprint author), Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, Grp Cytoanalysis, St Petersburg, Russia.; Belostotskaya, G (reprint author), Almazov Natl Med Res Ctr, Inst Expt Med, St Petersburg, Russia. | - |
dc.description.notes | gbelost@mail.ru; marc.hendrikx@uhasselt.be; galagoudza@mail.ru; | - |
dc.description.notes | ssuchkov57@gmail.com | - |
dc.description.other | Belostotskaya, G (reprint author), Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, Grp Cytoanalysis, St Petersburg, Russia; Almazov Natl Med Res Ctr, Inst Expt Med, St Petersburg, Russia. gbelost@mail.ru; marc.hendrikx@uhasselt.be; galagoudza@mail.ru; ssuchkov57@gmail.com | - |
local.publisher.place | ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 7874109 | - |
dc.source.type | Review | - |
dc.identifier.doi | 10.1155/2020/7874109 | - |
dc.identifier.pmid | 32190680 | - |
dc.identifier.isi | WOS:000522400400005 | - |
dc.identifier.eissn | 2314-6141 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | Belostotskaya, Galina; HENDRIKX, Marc; Galagudza, Michael & Suchkov, Sergey (2020) How to Stimulate Myocardial Regeneration in Adult Mammalian Heart: Existing Views and New Approaches. In: BIOMED RESEARCH INTERNATIONAL, 2020 (Art N° 7874109). | - |
item.contributor | Belostotskaya, Galina | - |
item.contributor | HENDRIKX, Marc | - |
item.contributor | Galagudza, Michael | - |
item.contributor | Suchkov, Sergey | - |
crisitem.journal.issn | 2314-6133 | - |
crisitem.journal.eissn | 2314-6141 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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galina.pdf | Published version | 759.74 kB | Adobe PDF | View/Open |
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