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http://hdl.handle.net/1942/31223
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DC Field | Value | Language |
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dc.contributor.author | ARROYO HORNERO, Rebeca | - |
dc.contributor.author | HAMAD, Ibrahim | - |
dc.contributor.author | FERNANDES CORTE-REAL, Beatriz | - |
dc.contributor.author | KLEINEWIETFELD, Markus | - |
dc.date.accessioned | 2020-05-26T14:30:52Z | - |
dc.date.available | 2020-05-26T14:30:52Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-05-04T11:50:29Z | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, 11 (Art N° 253) | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31223 | - |
dc.description.abstract | The rise in the prevalence of autoimmune diseases in developed societies has been associated with a change in lifestyle patterns. Among other factors, increased consumption of certain dietary components, such as table salt and fatty acids and excessive caloric intake has been associated with defective immunological tolerance. Dietary nutrients have shown to modulate the immune response by a direct effect on the function of immune cells or, indirectly, by acting on the microbiome of the gastrointestinal tract. FOXP3(+) regulatory T cells (Tregs) suppress immune responses and are critical for maintaining peripheral tolerance and immune homeostasis, modulating chronic tissue inflammation and autoimmune disease. It is now well-recognized that Tregs show certain degree of plasticity and can gain effector functions to adapt their regulatory function to different physiological situations during an immune response. However, plasticity of Tregs might also result in conversion into effector T cells that may contribute to autoimmune pathogenesis. Yet, which environmental cues regulate Treg plasticity and function is currently poorly understood, but it is of significant importance for therapeutic purposes. Here we review the current understanding on the effect of certain dietary nutrients that characterize Western diets in Treg metabolism, stability, and function. Moreover, we will discuss the role of Tregs linking diet and autoimmunity and the potential of dietary-based interventions to modulate Treg function in disease. | - |
dc.description.sponsorship | MK was supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (640116), by a SALK-grant from the government of Flanders, Belgium and by an Odysseus-grant of the Research Foundation Flanders (FWO), Belgium. | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | © 2020 Arroyo Hornero, Hamad, Côrte-Real and Kleinewietfeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | - |
dc.subject.other | diet | - |
dc.subject.other | microbiome | - |
dc.subject.other | Treg-regulatory T cell | - |
dc.subject.other | autoimmunity | - |
dc.subject.other | environmental factors | - |
dc.title | The Impact of Dietary Components on Regulatory T Cells and Disease | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 11 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Kleinewietfeld, M (reprint author), Univ Hasselt, VIB Lab Translat Immunomodulat, VIB Ctr Inflammat Res IRC, Hasselt, Belgium. | - |
dc.description.notes | markus.kleinewietfeld@uhasselt.vib.be | - |
dc.description.other | Kleinewietfeld, M (reprint author), Univ Hasselt, VIB Lab Translat Immunomodulat, VIB Ctr Inflammat Res IRC, Hasselt, Belgium. markus.kleinewietfeld@uhasselt.vib.be | - |
local.publisher.place | AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 253 | - |
dc.source.type | Review | - |
dc.identifier.doi | 10.3389/fimmu.2020.00253 | - |
dc.identifier.pmid | 32153577 | - |
dc.identifier.isi | WOS:000523705000001 | - |
dc.contributor.orcid | Arroyo Hornero, Rebeca/0000-0001-7026-7358 | - |
dc.identifier.eissn | - | |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | no | - |
item.fullcitation | ARROYO HORNERO, Rebeca; HAMAD, Ibrahim; FERNANDES CORTE-REAL, Beatriz & KLEINEWIETFELD, Markus (2020) The Impact of Dietary Components on Regulatory T Cells and Disease. In: FRONTIERS IN IMMUNOLOGY, 11 (Art N° 253). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.accessRights | Open Access | - |
item.contributor | ARROYO HORNERO, Rebeca | - |
item.contributor | HAMAD, Ibrahim | - |
item.contributor | FERNANDES CORTE-REAL, Beatriz | - |
item.contributor | KLEINEWIETFELD, Markus | - |
crisitem.journal.issn | 1664-3224 | - |
crisitem.journal.eissn | 1664-3224 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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rebeca.pdf | Published version | 711.85 kB | Adobe PDF | View/Open |
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