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http://hdl.handle.net/1942/31265
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DC Field | Value | Language |
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dc.contributor.author | TRAN, Mai Phuong Thao | - |
dc.contributor.author | ABRAMS, Steven | - |
dc.contributor.author | BRAEKERS, Roel | - |
dc.date.accessioned | 2020-06-04T10:11:27Z | - |
dc.date.available | 2020-06-04T10:11:27Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-06-02T13:57:19Z | - |
dc.identifier.citation | STATISTICS IN MEDICINE, 39 (12) , p. 1695 -1714 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31265 | - |
dc.description.abstract | The analysis of multivariate time-to-event (TTE) data can become complicated due to the presence of clustering, leading to dependence between multiple event times. For a long time, (conditional) frailty models and (marginal) copula models have been used to analyze clustered TTE data. In this article, we propose a general frailty model employing a copula function between the frailty terms to construct flexible (bivariate) frailty distributions with the application to current status data. The model has the advantage to impose a less restrictive correlation structure among latent frailty variables as compared to traditional frailty models. Specifically, our model uses a copula function to join the marginal distributions of the frailty vector. In this article, we considered different copula functions, and we relied on marginal gamma distributions due to their mathematical convenience. Based on a simulation study, our novel model outperformed the commonly used additive correlated gamma frailty model, especially in the case of a negative association between the frailties. At the end of the article, the new methodology is illustrated on real-life data applications entailing bivariate serological survey data. | - |
dc.description.sponsorship | Methusalem research grant from the Flemish government; IAP Research Network [P7/06]; Research Fund of Hasselt University [BOF11NI31] | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2020 John Wiley & Sons, Ltd. | - |
dc.subject.other | association | - |
dc.subject.other | copula functions | - |
dc.subject.other | frailty models | - |
dc.subject.other | maximum likelihood inference | - |
dc.subject.other | serological survey data | - |
dc.title | A general frailty model to accommodate individual heterogeneity in the acquisition of multiple infections: An application to bivariate current status data | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1714 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1695 | - |
dc.identifier.volume | 39 | - |
local.format.pages | 20 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Tran, TMP (reprint author), Hasselt Univ, Data Sci Inst, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. | - |
dc.description.notes | maiphuongthao.tran@uhasselt.be | - |
dc.description.other | Tran, TMP (reprint author), Hasselt Univ, Data Sci Inst, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. maiphuongthao.tran@uhasselt.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1002/sim.8506 | - |
dc.identifier.pmid | 32129520 | - |
dc.identifier.isi | WOS:000527887800001 | - |
dc.contributor.orcid | Tran, Thao Mai Phuong/0000-0003-2336-8302 | - |
dc.identifier.eissn | 1097-0258 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | TRAN, Mai Phuong Thao; ABRAMS, Steven & BRAEKERS, Roel (2020) A general frailty model to accommodate individual heterogeneity in the acquisition of multiple infections: An application to bivariate current status data. In: STATISTICS IN MEDICINE, 39 (12) , p. 1695 -1714. | - |
item.validation | ecoom 2021 | - |
item.contributor | TRAN, Mai Phuong Thao | - |
item.contributor | ABRAMS, Steven | - |
item.contributor | BRAEKERS, Roel | - |
crisitem.journal.issn | 0277-6715 | - |
crisitem.journal.eissn | 1097-0258 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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tran.pdf Restricted Access | Published version | 1.18 MB | Adobe PDF | View/Open Request a copy |
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