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Title: | Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD | Authors: | Maltais, Francois AUMANN, Joseph Kirsten, Anne-Marie Nadreau, Eric Macesic, Hemani Jin, Xidong Hamilton, Alan O'Donnell, Denis E. |
Issue Date: | 2019 | Publisher: | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Source: | The European respiratory journal, 53 (3) (Art N° 1802049) | Abstract: | The 3-min constant speed shuttle test (CSST) was used to examine the effect of tiotropium/olodaterol compared with tiotropium at reducing activity-related breathlessness in patients with chronic obstructive pulmonary disease (COPD). This was a randomised, double-blind, two-period crossover study including COPD patients with moderate to severe pulmonary impairment, lung hyperinflation at rest and a Mahler Baseline Dyspnoea Index <8. Patients received 6 weeks of tiotropium/olodaterol 5/5 mu g and tiotropium 5 mu g in a randomised order with a 3-week washout period. The speed for the 3-min CSST was determined for each patient such that an intensity of breathing discomfort >= 4 ("somewhat severe") on the modified Borg scale was reached at the end of a completed 3-min CSST. After 6 weeks, there was a decrease in the intensity of breathlessness (Borg dyspnoea score) at the end of the 3-min CSST from baseline with both tiotropium (mean -0.968, 95% CI -1.238--0.698; n=100) and tiotropium/olodaterol (mean -1.325, 95% CI -1.594--1.056; n=101). The decrease in breathlessness was statistically significantly greater with tiotropium/olodaterol versus tiotropium (treatment difference -0.357, 95% CI -0.661--0.053; p=0.0217). Tiotropium/olodaterol reduced activity-related breathlessness more than tiotropium in dyspnoeic patients with moderate to severe COPD exhibiting lung hyperinflation. | Notes: | Maltais, F (reprint author), Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, 2725 Chemin St Foy, Quebec City, PQ G1V 4G5, Canada. Francois.Maltais@fmed.ulaval.ca |
Document URI: | http://hdl.handle.net/1942/31331 | ISSN: | 0903-1936 | e-ISSN: | 1399-3003 | DOI: | 10.1183/13993003.02049-2018 | ISI #: | WOS:000467523800006 | Rights: | Copyright ©ERS 2019. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1802049.full.pdf | Published version | 609.2 kB | Adobe PDF | View/Open |
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