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http://hdl.handle.net/1942/31384
Title: | Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration | Authors: | Keller, Laetitia Pijnenburg, Luc Idoux-Gillet, Ysia Bornert, Fabien Benameur, Laila Tabrizian, Maryam Auvray, Pierrick Rosset, Philippe Gonzalo-Daganzo, Rosa Maria Barrena, Enrique Gomez GENTILE, Luca Benkirane-Jessel, Nadia |
Issue Date: | 2019 | Publisher: | NATURE PUBLISHING GROUP | Source: | Nature communications, 10 (Art N° 2156) | Abstract: | The extended life expectancy and the raise of accidental trauma call for an increase of osteoarticular surgical procedures. Arthroplasty, the main clinical option to treat osteoarticular lesions, has limitations and drawbacks. In this manuscript, we test the preclinical safety of the innovative implant ARTiCAR for the treatment of osteoarticular lesions. Thanks to the combination of two advanced therapy medicinal products, a polymeric nanofibrous bone wound dressing and bone marrow-derived mesenchymal stem cells, the ARTiCAR promotes both subchondral bone and cartilage regeneration. In this work, the ARTiCAR shows 1) the feasibility in treating osteochondral defects in a large animal model, 2) the possibility to monitor non-invasively the healing process and 3) the overall safety in two animal models under GLP preclinical standards. Our data indicate the preclinical safety of ARTiCAR according to the international regulatory guidelines; the ARTiCAR could therefore undergo phase I clinical trial. | Notes: | Benkirane-Jessel, N (reprint author), INSERM French Natl Inst Hlth & Med Res, UMR 1260, Regenerat Nanomed RNM, FMTS, 11 Rue Humann, F-67000 Strasbourg, France.; Benkirane-Jessel, N (reprint author), Univ Strasbourg, Fac Chirurg Dent, Hop Univ Strasbourg, 8 Rue Ste Elisabeth, F-67000 Strasbourg, France. nadia.jessel@inserm.fr |
Keywords: | Autologous Chondrocyte Implantation;Mesenchymal Stem-Cells;Articular-Cartilage Defects;Osteochondral Lesions;Knee;Repair;Microfracture;Transplantation;Trial;Joint | Document URI: | http://hdl.handle.net/1942/31384 | e-ISSN: | 2041-1723 | DOI: | 10.1038/s41467-019-10165-5 | ISI #: | WOS:000467836900010 | Rights: | Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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s41467-019-10165-5.pdf | Published version | 2.24 MB | Adobe PDF | View/Open |
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