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Title: | Partially Hydrolysed Whey-Based Formulae with Reduced Protein Content Support Adequate Infant Growth and Are Well Tolerated: Results of a Randomised Controlled Trial in Healthy Term Infants | Authors: | Rigo, Jacques Schoen, Stefanie Verghote, Marc van Overmeire, Bart Marion, Wivinne Abrahamse-Berkeveld, Marieke ALLIET, Philippe |
Issue Date: | 2019 | Publisher: | MDPI | Source: | Nutrients, 11 (7) (Art N° 1654) | Abstract: | The current study aimed to investigate growth, safety and tolerance of partially hydrolysed infant formulae in healthy full-term infants. Fully formula-fed infants were randomised <= 14 days of age to receive a partially hydrolysed whey formula with 2.27 g protein/100 kcal (pHF2.27) or the same formula with 1.8 g or 2.0 g protein/100 kcal (pHF1.8 and pHF2.0) until 4 months of age. The primary outcome was equivalence in daily weight gain within margins of +/- 3 g/day; comparison with WHO Child Growth Standards; gastrointestinal tolerance parameters and number of (serious) adverse events were secondary outcomes. A total of 207 infants were randomised, and 61 (pHF1.8), 46 (pHF2.0) and 48 (pHF2.27) infants completed the study per protocol. Equivalence in daily weight gain was demonstrated for the comparison of pHF1.8 and pHF2.27, i.e., the estimated difference was -1.12 g/day (90% CI: [-2.72; 0.47]) but was inconclusive for the comparisons of pHF2.0 and pHF2.27 with a difference of -2.52 g/day (90% CI: [-4.23; -0.81]). All groups showed adequate infant growth in comparison with the World Health Organization (WHO) Child Growth Standards. To conclude, the evaluated partially hydrolysed formulae varying in protein content support adequate growth and are safe and well tolerated in healthy infants. | Notes: | Alliet, P (reprint author), Jessa Hosp, Dept Pediat, Stadsomvaart 11, B-3500 Hasselt, Belgium. dr.philippe.alliet@gmail.com |
Keywords: | safety; protein; gastrointestinal tolerance; partially hydrolysed;;infant formula; growth | Document URI: | http://hdl.handle.net/1942/31407 | ISSN: | 2072-6643 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu11071654 | ISI #: | WOS:000478885400195 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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nutrients-11-01654-v2.pdf | Published version | 793.33 kB | Adobe PDF | View/Open |
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