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Title: | Hepatitis C virus (HCV) prevalence estimation in the adult general population in Belgium : a meta-analysis | Authors: | Muyldermans, G. BIELEN, Rob Botterman, R. Bourgeois, S. Colle, I Deressa, B. Devolder, G. Horsmans, Y. Hutse, V Lanthier, N. Lasser, L. Platteau, S. ROBAEYS, Geert Suin, V Verhelst, X. Van Vlierberghe, H. Van Baelen, L. |
Issue Date: | 2019 | Publisher: | UNIV CATHOLIQUE LOUVAIN-UCL | Source: | ACTA GASTRO-ENTEROLOGICA BELGICA, 82 (4) , p. 479 -485 | Abstract: | Background and study aims : Although multiple HCV prevalence studies were recently performed in the general population from Belgium, they suffer from a lack of geographical representativeness, an insufficient number of participants or a lack of inclusion of high prevalence groups. The aim of this study is to provide robust information on the HCV burden. Methods : Recently performed HCV prevalence studies in the general, adult population were included in this study, based on well-defined selection criteria. A meta analysis was performed to estimate the seroprevalence, the prevalence of participants with viremia send the prevalence estimation for people with viremia which were unaware of their status. Results : Eight studies fulfilled the criteria for inclusion of the quantitative prevalence estimation. Based on the meta-analysis on these 8 studies, we estimated an HCV seroprevalence of 1.01% 195% CI : 0.66-1.42%], representing a total of 90,722 adult, HCV seropositives of which 64,412 individuals (0.71%) were confirmed seropositive. Based on the RNA presence, an estimated viremic prevalence of 0.33% I95% CI : 0.21-0.47 %1 was determined, corresponding with 29,642 individuals. This is 46,0% of the true HCV seropositive residents. Further, based on the availability of patient information in 5 out of the 8 studies, a prevalence of 0.18% 195% CI : 0.07-0.33J representing 16,168 individuals from the adult Belgian population are unaware of their HCV status. Conclusions: We believe that the quantitative measurement by the meta-analysis will be more reliable for their use in the design of a screening strategy or in the development of prevention campaigns as compared to the prevalence estimations performed at local level. | Notes: | Muyldermans, G (reprint author), Sciensano, J Wytsmanst 14, B-1050 Brussels, Belgium. gaetan.muyldermans@sciensano.be |
Keywords: | meta-analysis;prevalence;hepatitis C virus | Document URI: | http://hdl.handle.net/1942/31417 | ISSN: | 1784-3227 | e-ISSN: | 1784-3227 | ISI #: | WOS:000509370700003 | Rights: | This is an open access journal which means that all content is freely available without charge to the user or his/her institution. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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Muyldermans_G_2019.pdf | Published version | 1.23 MB | Adobe PDF | View/Open |
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