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http://hdl.handle.net/1942/31419
Title: | Use of fosfomycin as targeted antibiotic prophylaxis before prostate biopsy: A prospective randomized study | Authors: | Van Besien, Jeroen UVIN, Pieter Weyne, Emmanuel Van Praet, Charles Merckx, Luc De Graeve, Nico VAN RENTERGHEM, Koenraad Cartuyvels, Reinoud Van den Abeele, Anne-Marie |
Issue Date: | 2019 | Publisher: | WILEY | Source: | INTERNATIONAL JOURNAL OF UROLOGY, 26 (3) , p. 391 -397 | Abstract: | Objectives To investigate whether switching ciprofloxacin to fosfomycin in the case of fluoroquinolone-resistant rectal bacteria influences the incidence of infectious complications after transrectal prostate biopsy. Methods From December 2015 until December 2017, patients undergoing prostate biopsy were randomly assigned to a control group or an intervention group in a prospective, open-label fashion at three different centers. The presence of fluoroquinolone-resistant organisms was detected by rectal swabs. Patients in the control group received ciprofloxacin. Patients in the intervention group received fosfomycin instead of ciprofloxacin in the case of fluoroquinolone-resistant bacteria on rectal swab culture. The primary end-point was the difference in occurrence of major (febrile) and minor (afebrile) infections between both groups. Results A total of 102 patients were randomized to the control group, and 102 patients to the intervention group. In the control group, nine complications occurred, of which five were major febrile complications. In the intervention group, six complications occurred, of which four were major febrile complications. The total number of complications (major and minor) did not differ between both groups (P = 0.59). A subgroup analysis of patients with fluoroquinolone-resistant bacteria on rectal swab showed five complications in the control group and one complication in the intervention group (P = 0.09). Conclusions This represents the first prospective randomized study using rectal cultures for targeted antibiotic prophylaxis. Study findings show promising results for use of fosfomycin in patients with fluoroquinolone resistance. | Notes: | Van Besien, J (reprint author), AZ St Lucas Hosp, Dept Urol, Groenebriel 1, B-9000 Ghent, Belgium. jeroen.vanbesien@gmail.com |
Keywords: | antibiotic prophylaxis; fosfomycin; prostate biopsy; rectal swab;;targeted therapy | Document URI: | http://hdl.handle.net/1942/31419 | ISSN: | 0919-8172 | e-ISSN: | 1442-2042 | DOI: | 10.1111/iju.13883 | ISI #: | WOS:000460300600013 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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