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http://hdl.handle.net/1942/31436
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DC Field | Value | Language |
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dc.contributor.author | VANHERLE, Sam | - |
dc.contributor.author | HAIDAR, Mansour | - |
dc.contributor.author | IROBI, Joy | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.date.accessioned | 2020-07-08T07:29:12Z | - |
dc.date.available | 2020-07-08T07:29:12Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-07-06T17:04:37Z | - |
dc.identifier.citation | Advanced drug delivery reviews, 159, p. 322-331. | - |
dc.identifier.issn | 0169-409X | - |
dc.identifier.uri | http://hdl.handle.net/1942/31436 | - |
dc.description.abstract | Increasing evidence indicates that lipid metabolism is disturbed in central nervous system (CNS) disorders, such as multiple sclerosis, Alzheimer's, and Parkinson's disease. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanosized particles that play an essential role in intercellular communication and tissue ho-meostasis by transporting diverse biologically active molecules, including a large variety of lipid species. In the last decade, studies defined that changes in the EV lipidome closely correlate with disease-progression and-remission in CNS disorders. In this review, we summarize and discuss these changes in the EV lipidome and elaborate on the impact of different EV-associated lipids on pathological processes in CNS disorders. We conclude that EV-associated lipids are closely associated with neuroinflammation, CNS repair, and pathological protein aggre-gation in CNS disorders, and that modulation of the EV lipidome represents a promising therapeutic strategy to halt disease progression in multiple sclerosis, Alzheimer's, and Parkinson's disease. Moreover, we predict that disease-stage specific EV-associated lipid signatures can be invaluable markers for the diagnosis and early detection of CNS disorders in the future. | - |
dc.description.sponsorship | This work was financially supported by the Research Foundation of Flanders (FWO Vlaanderen, (1S15519N, G099618FWO and 12J9119N)) and Interreg V-A EMR program (EURLIPIDS, EMR23). We thank J. van Haarlem for the graphical representations. We would also like to thank M. Loix, E. Grajchen, and T. Dierckx for revising the manuscript. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2020 Elsevier B.V. All rights reserved. | - |
dc.subject.other | CNS disorders | - |
dc.subject.other | Extracellular vesicles | - |
dc.subject.other | Lipids | - |
dc.subject.other | CNS repair | - |
dc.title | Extracellular vesicle-associated lipids in central nervous system disorders | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 331 | - |
dc.identifier.spage | 322 | - |
dc.identifier.volume | 159 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.addr.2020.04.011 | - |
dc.identifier.isi | WOS:000600557400016 | - |
dc.identifier.eissn | - | |
local.provider.type | CrossRef | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.contributor | VANHERLE, Sam | - |
item.contributor | HAIDAR, Mansour | - |
item.contributor | IROBI, Joy | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | HENDRIKS, Jerome | - |
item.accessRights | Restricted Access | - |
item.fullcitation | VANHERLE, Sam; HAIDAR, Mansour; IROBI, Joy; BOGIE, Jeroen & HENDRIKS, Jerome (2020) Extracellular vesicle-associated lipids in central nervous system disorders. In: Advanced drug delivery reviews, 159, p. 322-331.. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0169-409X | - |
crisitem.journal.eissn | 1872-8294 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S0169409X20300314-main.pdf Restricted Access | Published version | 1.14 MB | Adobe PDF | View/Open Request a copy |
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