Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/31469
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | QUADEN, Dana | - |
dc.contributor.author | VANDORMAEL, Patrick | - |
dc.contributor.author | RUYTINX, Pieter | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | CORTEN, Kristoff | - |
dc.contributor.author | VANHOOF, Johan | - |
dc.contributor.author | LIESENBORGS, Jori | - |
dc.contributor.author | VAN REETH, Frank | - |
dc.contributor.author | AGTEN, Anouk | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | de Vlam, Kurt | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2020-07-16T07:40:26Z | - |
dc.date.available | 2020-07-16T07:40:26Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-07-15T14:49:57Z | - |
dc.identifier.citation | Arthritis & rheumatology (Malden. Print), 72(12), p. 2094-2105 | - |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31469 | - |
dc.description.abstract | Objective The aim of this study was to identify novel autoantibodies in axial spondyloarthritis (axSpA) and determine their diagnostic potential in early axSpA patients and controls from two independent cohorts. Methods An axSpA cDNA phage display library was used to screen for novel immunoglobulin G (IgG) antibodies in plasma of early axSpA patients. Presence of these antibodies against novel Hasselt University (UH)‐axSpA peptides was determined in 76 early axSpA patients, 75 non‐specific chronic low back pain (CLBP) controls, 60 rheumatoid arthritis (RA) patients and 94 healthy controls (HC) from the UH cohort using enzyme‐linked immunosorbent assays (ELISA). Antibody reactivity was further validated in 174 axSpA patients from the Leuven Spondyloarthritis (Biologics) cohort ((Bio)SPAR), including 79 early axSpA patients. Results We identified antibodies to 9 novel UH‐axSpA peptides, corresponding to randomly formed peptides and to a novel axSpA autoantigen, Double Homeobox protein 4 (DUX4). Antibodies to 3 UH‐axSpA peptides with the highest positive likelihood ratio (LR+) were significantly more present in early axSpA patients from the UH and (Bio)SPAR cohorts (14.2% (22/155)) compared to CLBP (5% (4/75)), resulting in 95% specificity. The LR+ for confirming axSpA using antibodies to these 3 UH‐axSpA peptides was 2.7, which is higher than the currently used laboratory marker C‐reactive protein (CRP). Testing for antibodies to these 3 UH‐axSpA peptides in CLBP increased post‐test probability for axSpA from 79% to 91%. Conclusion Antibodies to 3 UH‐axSpA peptides could provide a novel tool for the diagnosis of a subset of axSpA patients. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2105 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 2094 | - |
dc.identifier.volume | 72 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/art.41427 | - |
dc.identifier.isi | WOS:000584901100001 | - |
dc.identifier.eissn | 2326-5205 | - |
local.provider.type | CrossRef | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | no | - |
item.fullcitation | QUADEN, Dana; VANDORMAEL, Patrick; RUYTINX, Pieter; GEUSENS, Piet; CORTEN, Kristoff; VANHOOF, Johan; LIESENBORGS, Jori; VAN REETH, Frank; AGTEN, Anouk; VANDENABEELE, Frank; de Vlam, Kurt & SOMERS, Veerle (2020) Antibodies against three novel peptides in early axial spondyloarthritis patients from two independent cohorts. In: Arthritis & rheumatology (Malden. Print), 72(12), p. 2094-2105. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | QUADEN, Dana | - |
item.contributor | VANDORMAEL, Patrick | - |
item.contributor | RUYTINX, Pieter | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | CORTEN, Kristoff | - |
item.contributor | VANHOOF, Johan | - |
item.contributor | LIESENBORGS, Jori | - |
item.contributor | VAN REETH, Frank | - |
item.contributor | AGTEN, Anouk | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | de Vlam, Kurt | - |
item.contributor | SOMERS, Veerle | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 2326-5191 | - |
crisitem.journal.eissn | 2326-5205 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art.41427.pdf Restricted Access | Published version | 513.04 kB | Adobe PDF | View/Open Request a copy |
June2020_Research Article_Quaden et al_ProofRead_CleanVersion_DQ.pdf | Peer-reviewed author version | 258.78 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
10
checked on May 1, 2024
Page view(s)
122
checked on Jun 30, 2022
Download(s)
56
checked on Jun 30, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.