Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/31835
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dc.contributor.authorFokas, Emmanouil-
dc.contributor.authorGlynne-Jones, Robert-
dc.contributor.authorAppelt, Ane-
dc.contributor.authorBeets-Tan, Regina-
dc.contributor.authorBeets, Geerard-
dc.contributor.authorHaustermans, Karin-
dc.contributor.authorMarijnen, Corrie-
dc.contributor.authorMinsky, Bruce D.-
dc.contributor.authorLudmir, Ethan-
dc.contributor.authorQuirke, Phil-
dc.contributor.authorSebag-Montefiore, David-
dc.contributor.authorGarcia-Aguilar, Julio-
dc.contributor.authorGambacorta, Maria Antonietta-
dc.contributor.authorValentini, Vincenzo-
dc.contributor.authorBUYSE, Marc-
dc.contributor.authorRodel, Claus-
dc.date.accessioned2020-08-25T14:58:45Z-
dc.date.available2020-08-25T14:58:45Z-
dc.date.issued2020-
dc.date.submitted2020-08-20T10:11:32Z-
dc.identifier.citationLANCET ONCOLOGY, 21 (5) , p. E252 -E264-
dc.identifier.urihttp://hdl.handle.net/1942/31835-
dc.description.abstractThere is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in inconsistency and difficulty of data interpretation. Also, surrogate properties of early and intermediate endpoints have not been systematically assessed. We provide a comprehensive review of clinical and surrogate endpoints used in trials for non-metastatic rectal cancer. The applicability, advantages, and disadvantages of these endpoints are summarised, with recommendations on clinical endpoints for the different phase trials, including limited surgery or non-operative management for organ preservation. We discuss how early and intermediate endpoints, including patient-reported outcomes and involvement of patients in decision making, can be used to guide trial design and facilitate consistency in reporting trial results in rectal cancer.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.rightsElsevier Inc. except certain content provided by third parties.-
dc.subject.otherTotal Mesorectal Excision-
dc.subject.otherSurrogate End-Points-
dc.subject.otherRandomized Phase-Iii-
dc.subject.otherShort-Course Radiotherapy-
dc.subject.otherDisease-Free Survival-
dc.subject.otherQuality-Of-Life-
dc.subject.otherPreoperative Radiotherapy-
dc.subject.otherFollow-Up-
dc.subject.otherPostoperative Chemoradiotherapy-
dc.subject.otherLocal Recurrence-
dc.titleOutcome measures in multimodal rectal cancer trials-
dc.typeJournal Contribution-
dc.identifier.epageE264-
dc.identifier.issue5-
dc.identifier.spageE252-
dc.identifier.volume21-
local.bibliographicCitation.jcatA1-
dc.description.notesFokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany.-
dc.description.notesemmanouil.fokas@kgu.de-
dc.description.otherFokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany. emmanouil.fokas@kgu.de-
local.publisher.placeSTE 800, 230 PARK AVE, NEW YORK, NY 10169 USA-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/S1470-2045(20)30024-3-
dc.identifier.pmid32359501-
dc.identifier.isiWOS:000540084200017-
dc.identifier.urlhttps://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(20)30024-3.pdf-
dc.contributor.orcidAppelt, Ane L/0000-0003-2792-9218-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany.-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany.-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] Frankfurt Canc Inst, Frankfurt, Germany.-
local.description.affiliation[Glynne-Jones, Robert] Mt Vernon Canc Ctr, Dept Radiotherapy, Northwood, Middx, England.-
local.description.affiliation[Appelt, Ane; Sebag-Montefiore, David] St Jamess Univ Leeds, Inst Med Res, Leeds, W Yorkshire, England.-
local.description.affiliation[Beets-Tan, Regina] Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands.-
local.description.affiliation[Beets, Geerard] Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands.-
local.description.affiliation[Marijnen, Corrie] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands.-
local.description.affiliation[Beets-Tan, Regina; Beets, Geerard] Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.-
local.description.affiliation[Haustermans, Karin] Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium.-
local.description.affiliation[Minsky, Bruce D.; Ludmir, Ethan] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.-
local.description.affiliation[Quirke, Phil] Univ Leeds, Div Pathol & Data Analyt, Sch Med, Leeds, W Yorkshire, England.-
local.description.affiliation[Garcia-Aguilar, Julio] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA.-
local.description.affiliation[Gambacorta, Maria Antonietta; Valentini, Vincenzo] Univ Cattolica Sacro Cuore, Dept Radiat Oncol, Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy.-
local.description.affiliation[Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium.-
local.description.affiliation[Buyse, Marc] Int Drug Dev Inst, San Francisco, CA USA.-
item.contributorFokas, Emmanouil-
item.contributorGlynne-Jones, Robert-
item.contributorAppelt, Ane-
item.contributorBeets-Tan, Regina-
item.contributorBeets, Geerard-
item.contributorHaustermans, Karin-
item.contributorMarijnen, Corrie-
item.contributorMinsky, Bruce D.-
item.contributorLudmir, Ethan-
item.contributorQuirke, Phil-
item.contributorSebag-Montefiore, David-
item.contributorGarcia-Aguilar, Julio-
item.contributorGambacorta, Maria Antonietta-
item.contributorValentini, Vincenzo-
item.contributorBUYSE, Marc-
item.contributorRodel, Claus-
item.fullcitationFokas, Emmanouil; Glynne-Jones, Robert; Appelt, Ane; Beets-Tan, Regina; Beets, Geerard; Haustermans, Karin; Marijnen, Corrie; Minsky, Bruce D.; Ludmir, Ethan; Quirke, Phil; Sebag-Montefiore, David; Garcia-Aguilar, Julio; Gambacorta, Maria Antonietta; Valentini, Vincenzo; BUYSE, Marc & Rodel, Claus (2020) Outcome measures in multimodal rectal cancer trials. In: LANCET ONCOLOGY, 21 (5) , p. E252 -E264.-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
item.validationecoom 2021-
crisitem.journal.issn1470-2045-
crisitem.journal.eissn1474-5488-
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