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http://hdl.handle.net/1942/31835
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DC Field | Value | Language |
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dc.contributor.author | Fokas, Emmanouil | - |
dc.contributor.author | Glynne-Jones, Robert | - |
dc.contributor.author | Appelt, Ane | - |
dc.contributor.author | Beets-Tan, Regina | - |
dc.contributor.author | Beets, Geerard | - |
dc.contributor.author | Haustermans, Karin | - |
dc.contributor.author | Marijnen, Corrie | - |
dc.contributor.author | Minsky, Bruce D. | - |
dc.contributor.author | Ludmir, Ethan | - |
dc.contributor.author | Quirke, Phil | - |
dc.contributor.author | Sebag-Montefiore, David | - |
dc.contributor.author | Garcia-Aguilar, Julio | - |
dc.contributor.author | Gambacorta, Maria Antonietta | - |
dc.contributor.author | Valentini, Vincenzo | - |
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | Rodel, Claus | - |
dc.date.accessioned | 2020-08-25T14:58:45Z | - |
dc.date.available | 2020-08-25T14:58:45Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-08-20T10:11:32Z | - |
dc.identifier.citation | LANCET ONCOLOGY, 21 (5) , p. E252 -E264 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31835 | - |
dc.description.abstract | There is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in inconsistency and difficulty of data interpretation. Also, surrogate properties of early and intermediate endpoints have not been systematically assessed. We provide a comprehensive review of clinical and surrogate endpoints used in trials for non-metastatic rectal cancer. The applicability, advantages, and disadvantages of these endpoints are summarised, with recommendations on clinical endpoints for the different phase trials, including limited surgery or non-operative management for organ preservation. We discuss how early and intermediate endpoints, including patient-reported outcomes and involvement of patients in decision making, can be used to guide trial design and facilitate consistency in reporting trial results in rectal cancer. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | Elsevier Inc. except certain content provided by third parties. | - |
dc.subject.other | Total Mesorectal Excision | - |
dc.subject.other | Surrogate End-Points | - |
dc.subject.other | Randomized Phase-Iii | - |
dc.subject.other | Short-Course Radiotherapy | - |
dc.subject.other | Disease-Free Survival | - |
dc.subject.other | Quality-Of-Life | - |
dc.subject.other | Preoperative Radiotherapy | - |
dc.subject.other | Follow-Up | - |
dc.subject.other | Postoperative Chemoradiotherapy | - |
dc.subject.other | Local Recurrence | - |
dc.title | Outcome measures in multimodal rectal cancer trials | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | E264 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | E252 | - |
dc.identifier.volume | 21 | - |
local.format.pages | 13 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Fokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany. | - |
dc.description.notes | emmanouil.fokas@kgu.de | - |
dc.description.other | Fokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany. emmanouil.fokas@kgu.de | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/S1470-2045(20)30024-3 | - |
dc.identifier.pmid | 32359501 | - |
dc.identifier.isi | WOS:000540084200017 | - |
dc.identifier.url | https://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(20)30024-3.pdf | - |
dc.contributor.orcid | Appelt, Ane L/0000-0003-2792-9218 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Fokas, Emmanouil; Rodel, Claus] Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany. | - |
local.description.affiliation | [Fokas, Emmanouil; Rodel, Claus] German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany. | - |
local.description.affiliation | [Fokas, Emmanouil; Rodel, Claus] Frankfurt Canc Inst, Frankfurt, Germany. | - |
local.description.affiliation | [Glynne-Jones, Robert] Mt Vernon Canc Ctr, Dept Radiotherapy, Northwood, Middx, England. | - |
local.description.affiliation | [Appelt, Ane; Sebag-Montefiore, David] St Jamess Univ Leeds, Inst Med Res, Leeds, W Yorkshire, England. | - |
local.description.affiliation | [Beets-Tan, Regina] Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Beets, Geerard] Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands. | - |
local.description.affiliation | [Marijnen, Corrie] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Beets-Tan, Regina; Beets, Geerard] Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands. | - |
local.description.affiliation | [Haustermans, Karin] Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium. | - |
local.description.affiliation | [Minsky, Bruce D.; Ludmir, Ethan] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA. | - |
local.description.affiliation | [Quirke, Phil] Univ Leeds, Div Pathol & Data Analyt, Sch Med, Leeds, W Yorkshire, England. | - |
local.description.affiliation | [Garcia-Aguilar, Julio] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA. | - |
local.description.affiliation | [Gambacorta, Maria Antonietta; Valentini, Vincenzo] Univ Cattolica Sacro Cuore, Dept Radiat Oncol, Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy. | - |
local.description.affiliation | [Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. | - |
local.description.affiliation | [Buyse, Marc] Int Drug Dev Inst, San Francisco, CA USA. | - |
local.uhasselt.international | yes | - |
item.fullcitation | Fokas, Emmanouil; Glynne-Jones, Robert; Appelt, Ane; Beets-Tan, Regina; Beets, Geerard; Haustermans, Karin; Marijnen, Corrie; Minsky, Bruce D.; Ludmir, Ethan; Quirke, Phil; Sebag-Montefiore, David; Garcia-Aguilar, Julio; Gambacorta, Maria Antonietta; Valentini, Vincenzo; BUYSE, Marc & Rodel, Claus (2020) Outcome measures in multimodal rectal cancer trials. In: LANCET ONCOLOGY, 21 (5) , p. E252 -E264. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.contributor | Fokas, Emmanouil | - |
item.contributor | Glynne-Jones, Robert | - |
item.contributor | Appelt, Ane | - |
item.contributor | Beets-Tan, Regina | - |
item.contributor | Beets, Geerard | - |
item.contributor | Haustermans, Karin | - |
item.contributor | Marijnen, Corrie | - |
item.contributor | Minsky, Bruce D. | - |
item.contributor | Ludmir, Ethan | - |
item.contributor | Quirke, Phil | - |
item.contributor | Sebag-Montefiore, David | - |
item.contributor | Garcia-Aguilar, Julio | - |
item.contributor | Gambacorta, Maria Antonietta | - |
item.contributor | Valentini, Vincenzo | - |
item.contributor | BUYSE, Marc | - |
item.contributor | Rodel, Claus | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1470-2045 | - |
crisitem.journal.eissn | 1474-5488 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Fokas_E_2020.pdf Restricted Access | Published version | 261.17 kB | Adobe PDF | View/Open Request a copy |
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