Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/31835
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFokas, Emmanouil-
dc.contributor.authorGlynne-Jones, Robert-
dc.contributor.authorAppelt, Ane-
dc.contributor.authorBeets-Tan, Regina-
dc.contributor.authorBeets, Geerard-
dc.contributor.authorHaustermans, Karin-
dc.contributor.authorMarijnen, Corrie-
dc.contributor.authorMinsky, Bruce D.-
dc.contributor.authorLudmir, Ethan-
dc.contributor.authorQuirke, Phil-
dc.contributor.authorSebag-Montefiore, David-
dc.contributor.authorGarcia-Aguilar, Julio-
dc.contributor.authorGambacorta, Maria Antonietta-
dc.contributor.authorValentini, Vincenzo-
dc.contributor.authorBUYSE, Marc-
dc.contributor.authorRodel, Claus-
dc.date.accessioned2020-08-25T14:58:45Z-
dc.date.available2020-08-25T14:58:45Z-
dc.date.issued2020-
dc.date.submitted2020-08-20T10:11:32Z-
dc.identifier.citationThe Lancet Oncology, 21 (5) , p. E252 -E264-
dc.identifier.urihttp://hdl.handle.net/1942/31835-
dc.description.abstractThere is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in inconsistency and difficulty of data interpretation. Also, surrogate properties of early and intermediate endpoints have not been systematically assessed. We provide a comprehensive review of clinical and surrogate endpoints used in trials for non-metastatic rectal cancer. The applicability, advantages, and disadvantages of these endpoints are summarised, with recommendations on clinical endpoints for the different phase trials, including limited surgery or non-operative management for organ preservation. We discuss how early and intermediate endpoints, including patient-reported outcomes and involvement of patients in decision making, can be used to guide trial design and facilitate consistency in reporting trial results in rectal cancer.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE INC-
dc.rightsElsevier Inc. except certain content provided by third parties.-
dc.subject.otherTotal Mesorectal Excision-
dc.subject.otherSurrogate End-Points-
dc.subject.otherRandomized Phase-Iii-
dc.subject.otherShort-Course Radiotherapy-
dc.subject.otherDisease-Free Survival-
dc.subject.otherQuality-Of-Life-
dc.subject.otherPreoperative Radiotherapy-
dc.subject.otherFollow-Up-
dc.subject.otherPostoperative Chemoradiotherapy-
dc.subject.otherLocal Recurrence-
dc.titleOutcome measures in multimodal rectal cancer trials-
dc.typeJournal Contribution-
dc.identifier.epageE264-
dc.identifier.issue5-
dc.identifier.spageE252-
dc.identifier.volume21-
local.format.pages13-
local.bibliographicCitation.jcatA1-
dc.description.notesFokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany.-
dc.description.notesemmanouil.fokas@kgu.de-
dc.description.otherFokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany. emmanouil.fokas@kgu.de-
local.publisher.placeSTE 800, 230 PARK AVE, NEW YORK, NY 10169 USA-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/S1470-2045(20)30024-3-
dc.identifier.pmid32359501-
dc.identifier.isiWOS:000540084200017-
dc.identifier.urlhttps://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(20)30024-3.pdf-
dc.contributor.orcidAppelt, Ane L/0000-0003-2792-9218-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] Goethe Univ Frankfurt, Dept Radiotherapy & Oncol, D-60590 Frankfurt, Germany.-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] German Canc Res Ctr, German Canc Consortium, Heidelberg, Germany.-
local.description.affiliation[Fokas, Emmanouil; Rodel, Claus] Frankfurt Canc Inst, Frankfurt, Germany.-
local.description.affiliation[Glynne-Jones, Robert] Mt Vernon Canc Ctr, Dept Radiotherapy, Northwood, Middx, England.-
local.description.affiliation[Appelt, Ane; Sebag-Montefiore, David] St Jamess Univ Leeds, Inst Med Res, Leeds, W Yorkshire, England.-
local.description.affiliation[Beets-Tan, Regina] Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands.-
local.description.affiliation[Beets, Geerard] Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands.-
local.description.affiliation[Marijnen, Corrie] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands.-
local.description.affiliation[Beets-Tan, Regina; Beets, Geerard] Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.-
local.description.affiliation[Haustermans, Karin] Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium.-
local.description.affiliation[Minsky, Bruce D.; Ludmir, Ethan] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.-
local.description.affiliation[Quirke, Phil] Univ Leeds, Div Pathol & Data Analyt, Sch Med, Leeds, W Yorkshire, England.-
local.description.affiliation[Garcia-Aguilar, Julio] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA.-
local.description.affiliation[Gambacorta, Maria Antonietta; Valentini, Vincenzo] Univ Cattolica Sacro Cuore, Dept Radiat Oncol, Fdn Policlin Univ Agostino Gemelli IRCCS, Rome, Italy.-
local.description.affiliation[Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium.-
local.description.affiliation[Buyse, Marc] Int Drug Dev Inst, San Francisco, CA USA.-
local.uhasselt.internationalyes-
item.fullcitationFokas, Emmanouil; Glynne-Jones, Robert; Appelt, Ane; Beets-Tan, Regina; Beets, Geerard; Haustermans, Karin; Marijnen, Corrie; Minsky, Bruce D.; Ludmir, Ethan; Quirke, Phil; Sebag-Montefiore, David; Garcia-Aguilar, Julio; Gambacorta, Maria Antonietta; Valentini, Vincenzo; BUYSE, Marc & Rodel, Claus (2020) Outcome measures in multimodal rectal cancer trials. In: The Lancet Oncology, 21 (5) , p. E252 -E264.-
item.accessRightsRestricted Access-
item.validationecoom 2021-
item.fulltextWith Fulltext-
item.contributorFokas, Emmanouil-
item.contributorGlynne-Jones, Robert-
item.contributorAppelt, Ane-
item.contributorBeets-Tan, Regina-
item.contributorBeets, Geerard-
item.contributorHaustermans, Karin-
item.contributorMarijnen, Corrie-
item.contributorMinsky, Bruce D.-
item.contributorLudmir, Ethan-
item.contributorQuirke, Phil-
item.contributorSebag-Montefiore, David-
item.contributorGarcia-Aguilar, Julio-
item.contributorGambacorta, Maria Antonietta-
item.contributorValentini, Vincenzo-
item.contributorBUYSE, Marc-
item.contributorRodel, Claus-
crisitem.journal.issn1470-2045-
crisitem.journal.eissn1474-5488-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
Fokas_E_2020.pdf
  Restricted Access		Published version261.17 kBAdobe PDFView/Open    Request a copy
Show simple item record

SCOPUSTM   
Citations

82
checked on Aug 23, 2025

WEB OF SCIENCETM
Citations

80
checked on Aug 25, 2025

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.