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http://hdl.handle.net/1942/3191
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DC Field | Value | Language |
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dc.contributor.author | Pauwels, RA | - |
dc.contributor.author | Yernault, JC | - |
dc.contributor.author | Demedts, MG | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.date.accessioned | 2007-11-27T08:43:34Z | - |
dc.date.available | 2007-11-27T08:43:34Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 157(3). p. 827-832 | - |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | http://hdl.handle.net/1942/3191 | - |
dc.description.abstract | There are still some concerns about the safety of high doses of inhaled glucocorticosteroids (ICS). We compared the safety and efficacy of fluticasone propionate (FP) and beclomethasone dipropionate (BDP) in 306 patients with moderate to severe asthma in a double-blind, multicenter, cross-over study of 12 mo duration. During the 1-mo run-in period, bronchodilators were replaced by salmeterol 50 mu g twice daily, increasing morning peak expiratory flow rate (PEFR) by 28 L/min (p < 0.001) and FEV1 by 6.2% predicted (p < 0.001). At randomization the current ICS was replaced by 500 mu g BDP or 250 mu g FP in accordance with previously taken 500 mu g BDP or 400 mu g budesonide (BUD). No significant differences between the two treatments regarding morning plasma cortisol, urinary excretion of calcium and hydroxyproline, FEV1, and PEFR were observed at any time point during the study. Osteocalcin and bone mineral density (BMD) were improved over baseline in the FP group, resulting in higher serum osteocalcin levels (mean difference 0.28 ng/ml; p < 0.001) and higher BMD in the spine (1.0%; p = 0.05), femoral neck (1.6; p < 0.01), and Ward's triangle (3.6%; p = 0.01) as compared with BDP. We conclude that chronic treatment with FP, at half the dose of BDP, results in a similar antiasthma effect but a more favorable safety profile with respect to bone metabolism and mineral density. | - |
dc.language.iso | en | - |
dc.publisher | AMER LUNG ASSOC | - |
dc.title | Safety and efficacy of fluticasone and beclomethasone in moderate to severe asthma | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 832 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 827 | - |
dc.identifier.volume | 157 | - |
local.format.pages | 6 | - |
dc.description.notes | State Univ Ghent Hosp, Dept Resp Dis, B-9000 Ghent, Belgium. Univ Hosp, Brussels, Belgium. Univ Hosp, Louvain, Belgium. LUC Diepenbeek, Dr Willems Inst, Diepenbeek, Belgium.Pauwels, RA, State Univ Ghent Hosp, Dept Resp Dis, De Pintelaan 185, B-9000 Ghent, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | 000072443200024 | - |
item.fullcitation | Pauwels, RA; Yernault, JC; Demedts, MG & GEUSENS, Piet (1998) Safety and efficacy of fluticasone and beclomethasone in moderate to severe asthma. In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 157(3). p. 827-832. | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 1999 | - |
item.contributor | Pauwels, RA | - |
item.contributor | Yernault, JC | - |
item.contributor | Demedts, MG | - |
item.contributor | GEUSENS, Piet | - |
item.accessRights | Closed Access | - |
Appears in Collections: | Research publications |
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