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http://hdl.handle.net/1942/31939
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DC Field | Value | Language |
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dc.contributor.author | Kunchok, Amy | - |
dc.contributor.author | Lechner-Scott, Jeannette | - |
dc.contributor.author | Granella, Franco | - |
dc.contributor.author | Trojano, Maria | - |
dc.contributor.author | Alroughani, Raed | - |
dc.contributor.author | Sola, Patrizia | - |
dc.contributor.author | Ferraro, Diana | - |
dc.contributor.author | Lugaresi, Alessandra | - |
dc.contributor.author | Onofrj, Marco | - |
dc.contributor.author | Ozakbas, Serkan | - |
dc.contributor.author | Izquierdo, Guillermo | - |
dc.contributor.author | Grammond, Pierre | - |
dc.contributor.author | Luis Sanchez-Menoyo, Jose | - |
dc.contributor.author | VAN WIJMEERSCH, Bart | - |
dc.contributor.author | Boz, Cavit | - |
dc.contributor.author | Pucci, Eugenio | - |
dc.contributor.author | McCombe, Pamela | - |
dc.contributor.author | Grand'Maison, Francois | - |
dc.contributor.author | Spitaleri, Daniele | - |
dc.contributor.author | Vucic, Steve | - |
dc.contributor.author | Hupperts, Raymond | - |
dc.contributor.author | Jokubaitis, Vilija | - |
dc.contributor.author | Sormani, Maria Pia | - |
dc.contributor.author | Butzkueven, Helmut | - |
dc.contributor.author | Kalincik, Tomas | - |
dc.date.accessioned | 2020-09-21T10:26:33Z | - |
dc.date.available | 2020-09-21T10:26:33Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2020-09-09T11:00:26Z | - |
dc.identifier.citation | MULTIPLE SCLEROSIS JOURNAL, 27(5), p. 695-705 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31939 | - |
dc.description.abstract | Background: The magnetic resonance imaging in multiple sclerosis (MAGNIMS) score combines relapses and magnetic resonance imaging (MRI) lesions to predict disability outcomes in relapsing-remitting multiple sclerosis (RRMS) treated with interferon-beta. Objective: To validate the MAGNIMS score and extend to other disease-modifying therapies (DMTs). To examine the prognostic value of gadolinium contrast-enhancing (Gd+) lesions. Methods: This RRMS MSBase cohort study (n = 2293) used a Cox model to examine the prognostic value of relapses, MRI activity and the MAGNIMS score for disability worsening during treatment with interferon-beta and three other DMTs. Results: Three new T2 lesions (hazard ratio (HR) = 1.60,p = 0.028) or two relapses (HR = 2.24,p = 0.002) on interferon-beta (for 12 months) were predictive of disability worsening over 4 years. MAGNIMS score = 2 (1 relapse and > 3 T2 lesions or > 2 relapses) was associated with a greater risk of disability worsening on interferon-beta (HR = 2.0,p = 0.001). In pooled cohort of four DMTs, similar associations were seen (MAGNIMS score = 2: HR = 1.72,p = 0.001). Secondary analyses demonstrated that the addition of Gd+ to the MAGNIMS did not materially improve its prediction of disability worsening. Conclusion: We have validated the MAGNIMS score in RRMS and extended its application to three other DMTs: 1 relapse and > 3 T2 lesions or > 2 relapses predicted worsening of disability. Contrast-enhancing lesions did not substantially improve the prognostic score. | - |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was financially supported by the National Health and Medical Research Council of Australia (project grants 1157717 and 1129189 and fellowships 1140766 and 1080518). The MSBase Foundation is a not-for-profit organization that receives support from Merck, Biogen, Novartis, Bayer-Schering, Sanofi Genzyme and Teva. The study was conducted separately and apart from the guidance of the sponsors. | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.rights | 2020 by SAGE Publications | - |
dc.subject.other | Multiple sclerosis | - |
dc.subject.other | therapy | - |
dc.subject.other | prediction | - |
dc.subject.other | magnetic resonance imaging | - |
dc.subject.other | outcomes | - |
dc.subject.other | prognosis | - |
dc.title | Prediction of on-treatment disability worsening in RRMS with the MAGNIMS score | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 705 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 695 | - |
dc.identifier.volume | 27 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Kalincik, T (corresponding author), Univ Melbourne, Royal Melbourne Hosp, Dept Med, CORe, 300 Grattan St,L4 East, Melbourne, Vic 3051, Australia. | - |
dc.description.notes | tomas.kalincik@unimelb.edu.au | - |
dc.description.other | Kalincik, T (corresponding author), Univ Melbourne, Royal Melbourne Hosp, Dept Med, CORe, 300 Grattan St,L4 East, Melbourne, Vic 3051, Australia. tomas.kalincik@unimelb.edu.au | - |
local.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1177/1352458520936823 | - |
dc.identifier.pmid | 32639855 | - |
dc.identifier.isi | WOS:000546608300001 | - |
dc.contributor.orcid | Alroughani, Raed/0000-0001-5436-5804 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Kunchok, Amy; Kalincik, Tomas] Univ Melbourne, Royal Melbourne Hosp, Dept Med, CORe, 300 Grattan St,L4 East, Melbourne, Vic 3051, Australia. | - |
local.description.affiliation | [Kunchok, Amy; Kalincik, Tomas] Royal Melbourne Hosp, Melbourne MS Ctr, Dept Neurol, Melbourne, Vic, Australia. | - |
local.description.affiliation | [Kunchok, Amy] Univ Sydney, Sydney, NSW, Australia. | - |
local.description.affiliation | [Kunchok, Amy] Mayo Clin, Dept Neurol, Rochester, MN USA. | - |
local.description.affiliation | [Lechner-Scott, Jeannette] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia. | - |
local.description.affiliation | [Lechner-Scott, Jeannette] Hunter New England Hlth, Dept Neurol, John Limiter Hosp, Newcastle, NSW, Australia. | - |
local.description.affiliation | [Granella, Franco] Univ Parma, Dept Med & Surg, Parma, Italy. | - |
local.description.affiliation | [Granella, Franco] Panne Univ Hosp, Dept Emergency & Gen Med, Parma, Italy. | - |
local.description.affiliation | [Trojano, Maria] Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy. | - |
local.description.affiliation | [Alroughani, Raed] Amiri Hosp, Dept Med, Div Neurol, Kuwait, Kuwait. | - |
local.description.affiliation | [Sola, Patrizia; Ferraro, Diana] Azienda Osped Univ, Dept Neurosci, Modena, Italy. | - |
local.description.affiliation | [Lugaresi, Alessandra] IRCCS Ist Sci Neurol Bologna, Bologna, Italy. | - |
local.description.affiliation | [Lugaresi, Alessandra] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie, Bologna, Italy. | - |
local.description.affiliation | [Onofrj, Marco] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Clin Neurol, Chieti, Italy. | - |
local.description.affiliation | [Ozakbas, Serkan] Dokuz Eylul Univ, Konak, Turkey. | - |
local.description.affiliation | [Izquierdo, Guillermo] Hosp Univ Virgen Macarena, Seville, Spain. | - |
local.description.affiliation | [Grammond, Pierre] CISSS Chaudiere Appalache, Levis, PQ, Canada. | - |
local.description.affiliation | [Luis Sanchez-Menoyo, Jose] Hosp Galdakao Usansolo, Galdakao, Spain. | - |
local.description.affiliation | [Van Wijmeersch, Bart] Rehabil & MS Ctr Overpelt, Overpelt, Belgium. | - |
local.description.affiliation | [Van Wijmeersch, Bart] Hasselt Univ, Hasselt, Belgium. | - |
local.description.affiliation | [Boz, Cavit] Farabi Hosp, KTU Med Fac, Trabzon, Turkey. | - |
local.description.affiliation | [Pucci, Eugenio] Azienda San Itaria Unica Reg Marche AV3, UOC Neurol, Macerate, Italy. | - |
local.description.affiliation | [McCombe, Pamela] Univ Queensland, Brisbane, Qld, Australia. | - |
local.description.affiliation | [McCombe, Pamela] Royal Brisbane & Womens Hosp, Herston, Qld, Australia. | - |
local.description.affiliation | [Grand'Maison, Francois] Neuro Rive Sud, Longueuil, PQ, Canada. | - |
local.description.affiliation | [Spitaleri, Daniele] Azienda Osped Rilievo Nazl San Giuseppe Moscati A, Avellino, Italy. | - |
local.description.affiliation | [Vucic, Steve] Univ Sydney, Westmead Hosp, Sydney, NSW, Australia. | - |
local.description.affiliation | [Hupperts, Raymond] Zuyderland Ziekenhuis, Sittard, Netherlands. | - |
local.description.affiliation | [Jokubaitis, Vilija; Butzkueven, Helmut] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia. | - |
local.description.affiliation | [Jokubaitis, Vilija; Butzkueven, Helmut] Alfred Hosp, Dept Med, Melbourne, Vic, Australia. | - |
local.description.affiliation | [Sormani, Maria Pia] Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy. | - |
local.uhasselt.international | yes | - |
item.contributor | Kunchok, Amy | - |
item.contributor | Lechner-Scott, Jeannette | - |
item.contributor | Granella, Franco | - |
item.contributor | Trojano, Maria | - |
item.contributor | Alroughani, Raed | - |
item.contributor | Sola, Patrizia | - |
item.contributor | Ferraro, Diana | - |
item.contributor | Lugaresi, Alessandra | - |
item.contributor | Onofrj, Marco | - |
item.contributor | Ozakbas, Serkan | - |
item.contributor | Izquierdo, Guillermo | - |
item.contributor | Grammond, Pierre | - |
item.contributor | Luis Sanchez-Menoyo, Jose | - |
item.contributor | VAN WIJMEERSCH, Bart | - |
item.contributor | Boz, Cavit | - |
item.contributor | Pucci, Eugenio | - |
item.contributor | McCombe, Pamela | - |
item.contributor | Grand'Maison, Francois | - |
item.contributor | Spitaleri, Daniele | - |
item.contributor | Vucic, Steve | - |
item.contributor | Hupperts, Raymond | - |
item.contributor | Jokubaitis, Vilija | - |
item.contributor | Sormani, Maria Pia | - |
item.contributor | Butzkueven, Helmut | - |
item.contributor | Kalincik, Tomas | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
item.fullcitation | Kunchok, Amy; Lechner-Scott, Jeannette; Granella, Franco; Trojano, Maria; Alroughani, Raed; Sola, Patrizia; Ferraro, Diana; Lugaresi, Alessandra; Onofrj, Marco; Ozakbas, Serkan; Izquierdo, Guillermo; Grammond, Pierre; Luis Sanchez-Menoyo, Jose; VAN WIJMEERSCH, Bart; Boz, Cavit; Pucci, Eugenio; McCombe, Pamela; Grand'Maison, Francois; Spitaleri, Daniele; Vucic, Steve; Hupperts, Raymond; Jokubaitis, Vilija; Sormani, Maria Pia; Butzkueven, Helmut & Kalincik, Tomas (2021) Prediction of on-treatment disability worsening in RRMS with the MAGNIMS score. In: MULTIPLE SCLEROSIS JOURNAL, 27(5), p. 695-705. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1352-4585 | - |
crisitem.journal.eissn | 1477-0970 | - |
Appears in Collections: | Research publications |
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amy.pdf Restricted Access | Published version | 572.03 kB | Adobe PDF | View/Open Request a copy |
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