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DC Field | Value | Language |
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dc.contributor.author | HENDRIX, Sophie | - |
dc.contributor.author | JOZEFCZAK, Marijke | - |
dc.contributor.author | Wojcik, M | - |
dc.contributor.author | DECKERS, Jana | - |
dc.contributor.author | VANGRONSVELD, Jaco | - |
dc.contributor.author | CUYPERS, Ann | - |
dc.date.accessioned | 2020-09-24T12:06:43Z | - |
dc.date.available | 2020-09-24T12:06:43Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-09-24T10:24:44Z | - |
dc.identifier.citation | Plant physiology and biochemistry (Paris), 154 , p. 498 -507 | - |
dc.identifier.issn | 0981-9428 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31962 | - |
dc.description.abstract | Glutathione (GSH) is an important player in plant responses to cadmium (Cd) through its dual function as an antioxidant and precursor for metal-chelating phytochelatins (PCs). In addition, it was shown to be involved in cell cycle regulation in Arabidopsis thaliana roots, but its involvement in this process in leaves is largely unknown and has never been evaluated in Cd-exposed plants. This study aimed to elucidate the role of GSH in leaf growth and development, metal chelation, nutrient homeostasis and cell cycle regulation in A. thaliana plants upon prolonged Cd exposure. Responses were compared between wild-type (WT) plants and three GSH-deficient mutants. Our results indicate that PC production remains important in plants exposed to Cd for an extended duration. Furthermore, an important role for GSH in regulating nutrient homeostasis in Cd-exposed plants was revealed. Cell cycle analysis demonstrated that negative effects of Cd exposure on cell division and endoreplication were more pronounced in leaves of the GSH-deficient cadmium-sensitive 2-1 (cad2-1) mutant in comparison to the WT, indicating the involvement of GSH in cell cycle regulation. Finally, a crucial role for GSH in transcriptional activation of the Cd-induced DNA damage response (DDR) was revealed, as the Cd-induced upregulation of DDR-related genes was either less pronounced or completely abolished in leaves of the GSH-deficient mutants. | - |
dc.description.sponsorship | This work was supported by Hasselt University through a PhD grant to Sophie Hendrix [grant number BOF14DOC04]. Additional funding came from FWO projects to Ann Cuypers [grant numbers G0B6716N, G0C7518N] and a PhD fellowship to Jana Deckers [grant number 1182220N]. We thank Ann Wijgaerts and Carine put for their skillful technical assistance. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.rights | 020 Published by Elsevier Masson SAS. | - |
dc.subject.other | Arabidopsis thaliana | - |
dc.subject.other | Cadmium | - |
dc.subject.other | Cell cycle | - |
dc.subject.other | DNA damage response | - |
dc.subject.other | Glutathione | - |
dc.subject.other | Nutrient homeostasis | - |
dc.subject.other | Phytochelatins | - |
dc.title | Glutathione: A key player in metal chelation, nutrient homeostasis, cell cycle regulation and the DNA damage response in cadmium-exposed Arabidopsis thaliana | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 507 | - |
dc.identifier.spage | 498 | - |
dc.identifier.volume | 154 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.plaphy.2020.06.006 | - |
dc.identifier.pmid | 32673998 | - |
dc.identifier.isi | WOS:000566818900048 | - |
local.provider.type | Web of Science | - |
local.uhasselt.uhpub | yes | - |
item.contributor | HENDRIX, Sophie | - |
item.contributor | JOZEFCZAK, Marijke | - |
item.contributor | Wojcik, M | - |
item.contributor | DECKERS, Jana | - |
item.contributor | VANGRONSVELD, Jaco | - |
item.contributor | CUYPERS, Ann | - |
item.fullcitation | HENDRIX, Sophie; JOZEFCZAK, Marijke; Wojcik, M; DECKERS, Jana; VANGRONSVELD, Jaco & CUYPERS, Ann (2020) Glutathione: A key player in metal chelation, nutrient homeostasis, cell cycle regulation and the DNA damage response in cadmium-exposed Arabidopsis thaliana. In: Plant physiology and biochemistry (Paris), 154 , p. 498 -507. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0981-9428 | - |
crisitem.journal.eissn | 1873-2690 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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HendrixS_2020.pdf Restricted Access | Published version | 3.91 MB | Adobe PDF | View/Open Request a copy |
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