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http://hdl.handle.net/1942/31997
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DC Field | Value | Language |
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dc.contributor.author | Camillo, Carlos Augusto | - |
dc.contributor.author | Osadnik, Christian Robert | - |
dc.contributor.author | BURTIN, Chris | - |
dc.contributor.author | Everaerts, Stephanie | - |
dc.contributor.author | Hornikx, Miek | - |
dc.contributor.author | Demeyer, Heleen | - |
dc.contributor.author | Loeckx, Matthias | - |
dc.contributor.author | Rodrigues, Fernanda Machado | - |
dc.contributor.author | Maes, Karen | - |
dc.contributor.author | Gayan-Ramirez, Ghislaine | - |
dc.contributor.author | Janssens, Wim | - |
dc.contributor.author | Troosters, Thierry | - |
dc.date.accessioned | 2020-09-30T13:54:23Z | - |
dc.date.available | 2020-09-30T13:54:23Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-09-28T14:40:24Z | - |
dc.identifier.citation | European respiratory journal (Online), 56 (3) (Art N° 2000639) | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | http://hdl.handle.net/1942/31997 | - |
dc.description.abstract | The development of contractile muscle fatigue (CMF) affects training responses in patients with chronic obstructive pulmonary disease (COPD). Downhill walking induces CMF with lower dyspnoea and fatigue than level walking. This study compared the effect of pulmonary rehabilitation (PR) comprising downhill walking training (DT) to PR comprising level walking (conventional training (CT)) in patients with COPD. In this randomised controlled trial, 35 patients (62±8 years; forced expiratory volume in 1 s (FEV1) 50±17% predicted) were randomised to DT or CT. Exercise tolerance (6-minute walk test distance (6MWD); primary outcome), muscle function, symptoms, quality-of-life and physical activity levels were assessed before and after PR. Absolute training changes and the proportion of patients exceeding the 30 m 6MWD minimally important difference (MID) were compared between groups. Quadriceps muscle biopsies were collected after PR in a subset of patients to examine physiological responses to long-term eccentric training. No between-group differences were observed in absolute 6MWD improvement (mean 6MWD change 77±46 m DT versus 56±47 m CT; p=0.45), however 94% of patients in DT exceeded the 6MWD MID compared to 65% in CT ( p=0.03). Patients in DT tended to have larger improvements than CT in other outcomes. Muscle biopsy analyses did not differ between groups. PR incorporating downhill walking confers similar magnitudes of effects to PR with conventional walking across clinical outcomes in patients with COPD, however, offers a more reliable stimulus to maximise the achievement of clinically relevant gains in functional exercise tolerance in people with COPD | - |
dc.description.sponsorship | : C.A. Camillo and F.M. Rodrigues were recipient of CNPq/Brazil fellowship (202425/2011–8); C.R. Osadnik is a recipient of a European Respiratory Society Fellowship (LTRF 2014–3132); T. Troosters is supported by Flemish Research Foundation (FWO # G·0871·13); H. Demeyer was the recipient of a joint ERS/SEPAR Fellowship (LTRF 2015). Funding information for this article has been deposited with the Crossref Funder Registry | - |
dc.language.iso | en | - |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | - |
dc.rights | ©ERS 2020. | - |
dc.subject.other | Muscle Strength | - |
dc.subject.other | Energy-Cost | - |
dc.subject.other | Exercise | - |
dc.subject.other | Responses | - |
dc.subject.other | Position | - |
dc.subject.other | Fatigue | - |
dc.subject.other | Tests | - |
dc.subject.other | Load | - |
dc.title | Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 3 | - |
dc.identifier.volume | 56 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2000639 | - |
dc.identifier.doi | 10.1183/13993003.00639-2020 | - |
dc.identifier.pmid | 32444407 | - |
dc.identifier.isi | WOS:000589173000010 | - |
dc.identifier.eissn | 1399-3003 | - |
local.provider.type | CrossRef | - |
local.uhasselt.uhpub | yes | - |
item.fullcitation | Camillo, Carlos Augusto; Osadnik, Christian Robert; BURTIN, Chris; Everaerts, Stephanie; Hornikx, Miek; Demeyer, Heleen; Loeckx, Matthias; Rodrigues, Fernanda Machado; Maes, Karen; Gayan-Ramirez, Ghislaine; Janssens, Wim & Troosters, Thierry (2020) Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial. In: European respiratory journal (Online), 56 (3) (Art N° 2000639). | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Camillo, Carlos Augusto | - |
item.contributor | Osadnik, Christian Robert | - |
item.contributor | BURTIN, Chris | - |
item.contributor | Everaerts, Stephanie | - |
item.contributor | Hornikx, Miek | - |
item.contributor | Demeyer, Heleen | - |
item.contributor | Loeckx, Matthias | - |
item.contributor | Rodrigues, Fernanda Machado | - |
item.contributor | Maes, Karen | - |
item.contributor | Gayan-Ramirez, Ghislaine | - |
item.contributor | Janssens, Wim | - |
item.contributor | Troosters, Thierry | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0903-1936 | - |
crisitem.journal.eissn | 1399-3003 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Peer reviewed author version.pdf | Peer-reviewed author version | 781.35 kB | Adobe PDF | View/Open |
2000639.full.pdf Restricted Access | Published version | 793.72 kB | Adobe PDF | View/Open Request a copy |
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