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http://hdl.handle.net/1942/32000
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | ter Maaten, Jozine M. | - |
dc.contributor.author | Vanhaen, Dimitri | - |
dc.contributor.author | HEEREN, Georges | - |
dc.contributor.author | Caers, Thalissa | - |
dc.contributor.author | Bovens, Becky | - |
dc.contributor.author | DAUW, Jeroen | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2020-09-30T14:13:43Z | - |
dc.date.available | 2020-09-30T14:13:43Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-09-01T13:47:30Z | - |
dc.identifier.citation | ACTA CARDIOLOGICA, 76(7), p. 718-726. | - |
dc.identifier.issn | 718 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32000 | - |
dc.description.abstract | Background:The heart failure (HF)-syndrome is associated with neuro-hormonal activation, chronic kidney disease (CKD), inflammation and alterations in the phosphorus-metabolism, all of which are involved in regulation of mineral bone density. However, the role of HF as an independent factor associated with metabolic bone disease (MBD) remains unclear. Methods:HF-patients undergoing dual X-ray absorptiometry (DEXA) were matched in a 1:2 fashion against age and gender matched controls without HF, to determine the proportion of osteoporosis (T-score < -2.5). HF-status was tested against known predictors of MBD. Correlation analysis and Z-score analysis were used to assess the impact of HF on age-related bone demineralisation. Results:A total of 190 HF-patients (age = 80 +/- 10 years, female = 61%) were age and gender matched to 380 controls. HF-patients had a higher proportion of osteoporosis (26 vs 17%;p = .007). HF patients had a lower averaged mineral bone density expressed in g/cm(2) (p = .030), T-scores (p = .001) and Z-scores (p < .001). After adjusting for the individual osteoporosis risk-factors of the FRAX-score, difference in baseline features, kidney function and phosphorus-metabolism alterations, heart failure remained independently associated with a lower averaged T-score (Adjusted beta= -0.189;p = .017). Heart failure was associated with an accelerated age-related decline in mineral bone density (p = .0418). Therapies with ACE-I or ARBs and beta-blockers associated with ameliorated bone demineralisation (p = .023, respectivelyp = .029), while loop diuretic associated with worsened bone demineralization (p < .001). Conclusion:Heart failure independently associates with MBD and higher prevalence of osteoporosis. Heart failure aggravates the aged related loss in mineral bone density while treatment with neuro-hormonal blockers seemed to ameliorate this finding. | - |
dc.description.sponsorship | Pieter Martens is supported by a doctoral fellowship by the Research Foundation - Flanders [FWO, grant-number: 11,27,917 N]. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.rights | Copyright © 2020 Informa UK Limited. | - |
dc.subject.other | Heart failure | - |
dc.subject.other | comorbidities | - |
dc.subject.other | geriatrics | - |
dc.subject.other | osteoporosis | - |
dc.subject.other | metabolic bone disease | - |
dc.title | Heart failure is associated with accelerated age related metabolic bone disease | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 7 | - |
dc.identifier.volume | 76 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Martens, P (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
dc.description.notes | Pieter_martens@icloud.com | - |
dc.description.other | Martens, P (corresponding author), Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. Pieter_martens@icloud.com | - |
local.publisher.place | 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1080/00015385.2020.1771885 | - |
dc.identifier.pmid | 32498656 | - |
dc.identifier.isi | WOS:000542775900001 | - |
dc.identifier.eissn | 726 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Martens, Pieter; Vanhaen, Dimitri; Heeren, Ellen; Caers, Thalissa; Bovens, Becky; Dauw, Jeroen; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Martens, Pieter; Dauw, Jeroen] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [ter Maaten, Jozine M.] Univ Groningen, Univ Med Ctr Groningen UMCG, Dept Cardiol, Groningen, Netherlands. | - |
local.description.affiliation | [Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.fullcitation | MARTENS, Pieter; ter Maaten, Jozine M.; Vanhaen, Dimitri; HEEREN, Georges; Caers, Thalissa; Bovens, Becky; DAUW, Jeroen; DUPONT, Matthias & MULLENS, Wilfried (2020) Heart failure is associated with accelerated age related metabolic bone disease. In: ACTA CARDIOLOGICA, 76(7), p. 718-726.. | - |
item.accessRights | Open Access | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | ter Maaten, Jozine M. | - |
item.contributor | Vanhaen, Dimitri | - |
item.contributor | HEEREN, Georges | - |
item.contributor | Caers, Thalissa | - |
item.contributor | Bovens, Becky | - |
item.contributor | DAUW, Jeroen | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | MULLENS, Wilfried | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 0001-5385 | - |
crisitem.journal.eissn | 1784-973X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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78278518_6102558_HF_and_MBD_FINAL_revised_with_figures.pdf | Peer-reviewed author version | 846.52 kB | Adobe PDF | View/Open |
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