Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/32012
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dc.contributor.authorVRIJSEN, Jeroen-
dc.contributor.authorRasines Mazo, Alicia-
dc.contributor.authorJUNKERS, Tanja-
dc.contributor.authorQiao, Greg Guanghua-
dc.date.accessioned2020-10-01T08:15:19Z-
dc.date.available2020-10-01T08:15:19Z-
dc.date.issued2020-
dc.date.submitted2020-09-09T13:03:04Z-
dc.identifier.citationMACROMOLECULAR RAPID COMMUNICATIONS, 41(18), (Art N° 2000071)-
dc.identifier.issn1022-1336-
dc.identifier.urihttp://hdl.handle.net/1942/32012-
dc.description.abstractIn nature, polypeptide-based materials are ubiquitous, yet their synthetic production is hampered by high cost, limited scalability, and often stringent reaction conditions. Herein an elegant approach is presented forN-carboxyanhydride ring opening polymerization (NCA ROP) ofN epsilon-benzyloxycarbonyl-l-lysine (ZLL) and gamma-benzyl-l-glutamate (BLG) NCA in continuous flow. The polymerization is initiated by primary amine initiators usingN,N-dimethylformamide (DMF) as solvent. Carrying out the reaction in a silicon microflow reactor speeds up the rate of ROP (92% conversion in 40 min in flow as opposed to 6 h in batch) due to highly efficient permeation of CO(2)through the reactor tubing. The polymerization strategy provides a facile, scale-up friendly alternative to traditional batch mode polymerization and has the capability of streamlining NCA ROP.-
dc.description.sponsorshipJ.H.V. was funded by the Research Foundation - Flanders (FWO) in the form of a scholarship (Strategic Basic Research) as well as an additional travel grant in the form of a scientific prize (Gustave Boel - Sofina Fellowship). A.R.M. was funded by the Australian Government Research Training Program Scholarship. The authors wish to thank Stephen P. Best for the generous use of a glovebox that made these experiments possible, as well as the thoughtful discussions that guided the direction of this research.-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.rights2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.subject.othercontinuous flow chemistry-
dc.subject.otherflow polymerization-
dc.subject.otherN-carboxyanhydride ring opening polymerization-
dc.titleAccelerated Polypeptide Synthesis via N ‐Carboxyanhydride Ring Opening Polymerization in Continuous Flow-
dc.typeJournal Contribution-
dc.identifier.issue18-
dc.identifier.volume41-
local.bibliographicCitation.jcatA1-
dc.description.notesQiao, GG (corresponding author), Univ Melbourne, Polymer Sci Grp, Dept Chem Engn, Parkville, Vic 3010, Australia.; Junkers, T (corresponding author), Hasselt Univ, Organ & Bio Polymer Chem, Inst Mat Res, Agoralaan, B-3590 Diepenbeek, Belgium.; Junkers, T (corresponding author), Monash Univ, Polymer React Design Grp, Sch Chem, Clayton, Vic 3800, Australia.-
dc.description.notestanja.junkers@monash.edu; gregghq@unimelb.edu.au-
dc.description.otherQiao, GG (corresponding author), Univ Melbourne, Polymer Sci Grp, Dept Chem Engn, Parkville, Vic 3010, Australia. Junkers, T (corresponding author), Hasselt Univ, Organ & Bio Polymer Chem, Inst Mat Res, Agoralaan, B-3590 Diepenbeek, Belgium; Monash Univ, Polymer React Design Grp, Sch Chem, Clayton, Vic 3800, Australia. tanja.junkers@monash.edu; gregghq@unimelb.edu.au-
local.publisher.placePOSTFACH 101161, 69451 WEINHEIM, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr2000071-
dc.identifier.doi10.1002/marc.202000071-
dc.identifier.pmid32691465-
dc.identifier.isiWOS:000550449800001-
dc.contributor.orcidVrijsen, Jeroen/0000-0002-8067-9337; Rasines Mazo,-
dc.contributor.orcidAlicia/0000-0001-6256-1979-
dc.identifier.eissn1521-3927-
dc.identifier.eissn1521-3927-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Vrijsen, Jeroen Hendrik; Rasines Mazo, Alicia; Qiao, Greg Guanghua] Univ Melbourne, Polymer Sci Grp, Dept Chem Engn, Parkville, Vic 3010, Australia.-
local.description.affiliation[Vrijsen, Jeroen Hendrik; Junkers, Tanja] Hasselt Univ, Organ & Bio Polymer Chem, Inst Mat Res, Agoralaan, B-3590 Diepenbeek, Belgium.-
local.description.affiliation[Junkers, Tanja] Monash Univ, Polymer React Design Grp, Sch Chem, Clayton, Vic 3800, Australia.-
local.uhasselt.internationalyes-
item.validationecoom 2021-
item.contributorVRIJSEN, Jeroen-
item.contributorRasines Mazo, Alicia-
item.contributorJUNKERS, Tanja-
item.contributorQiao, Greg Guanghua-
item.accessRightsRestricted Access-
item.fullcitationVRIJSEN, Jeroen; Rasines Mazo, Alicia; JUNKERS, Tanja & Qiao, Greg Guanghua (2020) Accelerated Polypeptide Synthesis via N ‐Carboxyanhydride Ring Opening Polymerization in Continuous Flow. In: MACROMOLECULAR RAPID COMMUNICATIONS, 41(18), (Art N° 2000071).-
item.fulltextWith Fulltext-
crisitem.journal.issn1022-1336-
crisitem.journal.eissn1521-3927-
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