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http://hdl.handle.net/1942/3223
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DC Field | Value | Language |
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dc.contributor.author | VANDEVYVER, CAROLINE | - |
dc.contributor.author | MOTMANS, KRIS | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | ZHANG, JINGWU | - |
dc.contributor.author | RAUS, Jef | - |
dc.date.accessioned | 2007-11-27T10:53:58Z | - |
dc.date.available | 2007-11-27T10:53:58Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | AUTOIMMUNITY, 28(2). p. 77-89 | - |
dc.identifier.issn | 0891-6934 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3223 | - |
dc.description.abstract | Autoimmune mechanisms involving T-cell responses to (a) myelin autoantigen(s), such as myelin basic protein (MBP), are thought to contribute to the pathogenesis of multiple sclerosis (MS), Cytokines may play a central role in the regulation of the pathogenic autoimmune responses in MS and the mediation of tissue damage in the disease. To study the cytokine expression of myelin reactive T-cells in MS, we determined the cytokine mRNA levels in a panel of blood derived MBP-specific T-cell clones derived from MS patients (33 clones) and normal controls (21 clones), using a novel quantitative RT-PCR method. Our results demonstrate that MBP-specific T-cells, both from MS patients and control subjects, predominantly display a Th1- or Th0-like cytokine pattern. Although MS clones express higher levels of TNF alpha and IL-10 mRNA, these differences do not reach statistical significance, Interestingly, significantly increased TNF alpha and IFN gamma mRNA levels were observed among clones derived from HLA-DR2 positive versus HLA-DR2 negative MS patients. This HLA halpotype is known to be associated with MS. The high levels of TNF alpha and IFN gamma mRNA observed in MBP-reactive T-cell clones from MS patients indicate an important role of these cytokines in the disease process. Our data lend further support to the pathogenic role of MBP-reactive T-cells in MS. | - |
dc.language.iso | en | - |
dc.publisher | HARWOOD ACAD PUBL GMBH | - |
dc.subject.other | cytokine; MBP-specific; T-cell clones; multiple sclerosis | - |
dc.title | Cytokine mRNA profile of myelin basic protein reactive T-cell clones in patients with multiple sclerosis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 89 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 77 | - |
dc.identifier.volume | 28 | - |
local.format.pages | 13 | - |
dc.description.notes | Dr Willems Inst, Dept Immunol, B-3590 Diepenbeek, Belgium.Stinissen, P, Dr Willems Inst, Dept Immunol, Univ Campus, B-3590 Diepenbeek, Belgium.pstiniss@luc.ac.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | 000076124200003 | - |
item.validation | ecoom 1999 | - |
item.accessRights | Closed Access | - |
item.fullcitation | VANDEVYVER, CAROLINE; MOTMANS, KRIS; STINISSEN, Piet; ZHANG, JINGWU & RAUS, Jef (1998) Cytokine mRNA profile of myelin basic protein reactive T-cell clones in patients with multiple sclerosis. In: AUTOIMMUNITY, 28(2). p. 77-89. | - |
item.fulltext | No Fulltext | - |
item.contributor | VANDEVYVER, CAROLINE | - |
item.contributor | MOTMANS, KRIS | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | ZHANG, JINGWU | - |
item.contributor | RAUS, Jef | - |
Appears in Collections: | Research publications |
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