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Title: | Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study | Authors: | VRIJENS, Karen Van Overmeire, Ilse De Cremer, Koen NEVEN, Kristof CAROLLO, Riccardo Vleminckx, Christiane Van Loco, Joris NAWROT, Tim |
Issue Date: | 2020 | Publisher: | BMC | Source: | ENVIRONMENTAL HEALTH, 19 (1) (Art N° 83) | Abstract: | Background Parabens are a group of esters of para-hydroxybenzoic acid utilized as antimicrobial preservatives in many personal care products. Epidemiological studies regarding the adverse effects of parabens on fetuses are limited. The aim of this study was to determine the association between placental paraben exposure and birth outcomes. We assessed paraben concentrations in placental tissue, which potentially gives a better understanding of fetal exposure than the maternal urinary concentrations which are the current golden standard. Methods Placental tissue was collected immediately after birth from 142 mother-child pairs from the ENVIRONAGE birth cohort. The placental concentrations of four parabens (methyl (MeP), ethyl (EtP), propyl (PrP), and butyl (BuP)) were determined by ultra-performance liquid chromatography coupled with tandem mass-spectrometry. Generalized linear regression models were used to determine the association between paraben exposure levels and birth outcomes. Results The geometric means of placental MeP, EtP, PrP, and BuP were 1.84, 2.16, 1.68 and 0.05 ng/g tissue, respectively. The sum of parabens ( n-ary sumation parabens, including MeP, EtP and PrP) was negatively associated with birth weight in newborn girls (- 166 g, 95% CI: - 322, - 8.6,p = 0.04) after adjustment for a priori selected covariates. The sum of parabens was negatively associated with head circumference (- 0.6 cm, 95% CI: - 1.1, - 0.2,p = 0.008) and borderline associated with birth length (- 0.6 cm, 95% CI:-1.3, 0.1,p = 0.08). In newborn girls the placental concentration of EtP was negatively associated with head circumference (- 0.6 cm, 95% CI:-1.1, - 0.1,p = 0.01) and borderline significantly associated with birth weight and birth length. Lastly, placental EtP and n-ary sumation parabens were negatively associated with placental weight in newborn girls but not in newborn boys (- 45.3 g, 95% CI:-86.2, - 4.4,p = 0.03). Conclusion The negative association between maternal paraben exposure and birth outcomes warrants further research and follow-up over time to determine long term effects of gestational exposure to parabens. | Notes: | Vrijens, K (corresponding author), Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. Karen.vrijens@uhasselt.be |
Other: | Vrijens, K (corresponding author), Hasselt Univ, Ctr Environm Sci, B-3590 Diepenbeek, Belgium. Karen.vrijens@uhasselt.be | Keywords: | Paraben exposure;Placental paraben concentrations;Birth cohort;Birth weight and length | Document URI: | http://hdl.handle.net/1942/32617 | e-ISSN: | 1476-069X | DOI: | 10.1186/s12940-020-00635-5 | ISI #: | WOS:000553301200001 | Rights: | © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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