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Title: Safety and efficacy of photobiomodulation therapy in oncology: A systematic review
Authors: Bensadoun, René‐Jean
Epstein, Joel B.
Nair, Raj G.
Barasch, Andrei
Raber‐Durlacher, Judith E.
Migliorati, Cesar
Genot‐Klastersky, Marie‐Thérèse
Treister, Nathaniel
Arany, Praveen
ROBIJNS, Jolien 
Issue Date: 2020
Source: Cancer Medicine, 9 (22) , p. 8279 -8300
Abstract: We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow-up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy-related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
Keywords: cancer;photobiomodulation;safety;supportive care;systematic review
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ISSN: 2045-7634
e-ISSN: 2045-7634
DOI: 10.1002/cam4.3582
ISI #: WOS:000583612900001
Rights: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Category: A1
Type: Journal Contribution
Validations: ecoom 2021
Appears in Collections:Research publications

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