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DC Field | Value | Language |
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dc.contributor.author | Goërtz, Yvonne | - |
dc.contributor.author | VAN HERCK, Maarten | - |
dc.contributor.author | Delbressine, Jeannet | - |
dc.contributor.author | Vaes, Anouk | - |
dc.contributor.author | Meys, Roy | - |
dc.contributor.author | Machado, Felipe | - |
dc.contributor.author | Houben-Wilke, Sarah | - |
dc.contributor.author | BURTIN, Chris | - |
dc.contributor.author | Posthuma, Rein | - |
dc.contributor.author | Franssen, Frits | - |
dc.contributor.author | Van Loon, Nicole | - |
dc.contributor.author | Hajian, Bita | - |
dc.contributor.author | Spies, Yvonne | - |
dc.contributor.author | Vijlbrief, Herman | - |
dc.contributor.author | Van't Hul, Alex | - |
dc.contributor.author | Janssen, Daisy | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.date.accessioned | 2020-11-23T09:26:37Z | - |
dc.date.available | 2020-11-23T09:26:37Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020-10-27T06:57:48Z | - |
dc.identifier.citation | ERJ open research, 6 (4) (Art N° 00542-2020) | - |
dc.identifier.issn | 2312-0541 | - |
dc.identifier.uri | http://hdl.handle.net/1942/32647 | - |
dc.description.abstract | Background: Many patients with COVID-19 did not require hospitalisation, nor underwent COVID-19 testing. There is anecdotal evidence that patients with "mild" COVID-19 may complain about persistent symptoms, even weeks after the infection. This suggests that symptoms during the infection may not resolve spontaneously. The objective of this study was to assess whether multiple relevant symptoms recover following the onset of symptoms in hospitalised and nonhospitalised patients with COVID-19. Methods: A total of 2113 members of two Facebook groups for coronavirus patients with persistent complaints in the Netherlands and Belgium, and from a panel of people who registered on a website of the Lung Foundation Netherlands, were assessed for demographics, pre-existing comorbidities, health status, date of symptoms onset, COVID-19 diagnosis, healthcare utilisation, and the presence of 29 symptoms at the time of the onset of symptoms (retrospectively) and at follow-up (mean±SD 79±17 days after symptoms onset). Results: Overall, 112 hospitalised patients and 2001 nonhospitalised patients (confirmed COVID-19, n=345; symptom-based COVID-19, n=882; and suspected COVID-19, n=774) were analysed. The median number of symptoms during the infection reduced significantly over time (median (interquartile range) 14 (11-17) versus 6 (4-9); p<0.001). Fatigue and dyspnoea were the most prevalent symptoms during the infection and at follow-up (fatigue: 95% versus 87%; dyspnoea: 90% versus 71%). Conclusion: In previously hospitalised and nonhospitalised patients with confirmed or suspected COVID-19, multiple symptoms are present about 3 months after symptoms onset. This suggests the presence of a "post-COVID-19 syndrome" and highlights the unmet healthcare needs in a subgroup of patients with "mild" or "severe" COVID-19. | - |
dc.description.sponsorship | Acknowledgements: The research team acknowledges the valuable input from the patient representatives to develop the survey and the technical support by Martijn Briejer and Oscar Wagemakers (ASolutions BV, Capelle an den IJssel, the Netherlands). Support statement: The scientific work of Y.M.J. Goërtz is financially supported by Lung Foundation Netherlands grant 4.1.16.085, F.V.C. Machado is financially supported by European Union grant ZonMw ERACoSysMed 90030355 and R. Meys is financially supported by Lung Foundation Netherlands grant 5.1.18.232. Funding information for this article has been deposited with the Crossref Funder Registry | - |
dc.language.iso | en | - |
dc.publisher | European Respiratory Society | - |
dc.rights | Copyright ©ERS 2020 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. | - |
dc.subject.other | Previously hospitalised and nonhospitalised #COVID19 patients can still have multiple persistent symptoms 3 months after the onset of infection-related symptoms. This provides the first evidence for a “post-COVID-19 syndrome” #longCOVID | - |
dc.title | Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 00542-2020 | - |
dc.identifier.volume | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND | - |
dc.relation.references | 1 Johns Hopkins University & Medicine. Coronavirus Resource Center. https://coronavirus.jhu.edu/ Date last updated: 8 July, 2020. Date last accessed: 9 July, 2020. 2 Li LQ, Huang T, Wang YQ, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol 2020; 92: 577–583. 3 Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708–1720. 4 Carfì A, Bernabei R, Landi F, et al. Persistent symptoms in patients after acute COVID-19. JAMA 2020; 324: 603–605. 5 Li R, Pei S, Chen B, et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2). Science 2020; 368: 489–493. 6 Stringhini S, Wisniak A, Piumatti G, et al. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study. Lancet 2020; 396: 313–319. 7 Centers for Disease Control and Prevention. Interim Guidance for Implementing Home Care of People Not Requiring Hospitalization for Coronavirus Disease 2019 (COVID-19). www.cdc.gov/coronavirus/2019-ncov/downloads/guidance-home-care.pdf Date last updated: 28 June, 2020. Date last accessed: 9 July, 2020. 8 Gandhi RT, Lynch JB, Del Rio C. Mild or moderate COVID-19. N Engl J Med 2020; in press [https://doi.org/10.1056/NEJMcp2009249]. 9 Garner P. The BMJ opinion: COVID-19 and fatigue – a game of snakes and ladders. https://blogs.bmj.com/bmj/2020/05/19/paul-garner-covid-19-and-fatigue-a-game-of-snakes-and-ladders/ Date last updated: 19 May, 2020. Date last accessed: 9 July, 2020. 10 The Atlantic. COVID-19 can last for several months: the disease’s “long-haulers” have endured relentless waves of debilitating symptoms – and disbelief from doctors and friends. Date last updated: 4 June, 2020. Date last accessed: 9 July, 2020. www.theatlantic.com/health/archive/2020/06/covid-19-coronavirus-longterm-symptomsmonths/612679/. 11 Public Facebook Group: Corona ervaringen en langdurige klachten! 2020. www.facebook.com/groups/236723204035929.9 Date last updated: 9 July, 2020. Date last accessed: 9 July, 2020. 12 Public Facebook Group: Corona patiënten met langdurige klachten (Vlaanderen). 2020. www.facebook.com/groups/241043323639334 Date last updated: 9 July, 2020. Date last accessed: 9 July, 2020. 13 Docherty AB, Harrison EM, Green CA, et al. Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO clinical characterisation protocol: prospective observational cohort study. BMJ 2020; 369: m1985. 14 Lechien JR, Chiesa-Estomba CM, Place S, et al. Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019. J Intern Med 2020; 288: 335–344. 15 Lam MH, Wing YK, Yu MW, et al. Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up. Arch Intern Med 2009; 169: 2142–2147. 16 Moldofsky H, Patcai J. Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. BMC Neurol 2011; 11: 37. 17 Schanke AK, Stanghelle JK. Fatigue in polio survivors. Spinal Cord 2001; 39: 243–251. 18 Voss JG. Predictors and correlates of fatigue in HIV/AIDS. J Pain Symptom Manage 2005; 29: 173–184. 19 Svenningsen H, Langhorn L, Ågård AS, et al. Post-ICU symptoms, consequences, and follow-up: an integrative review. Nurs Crit Care 2017; 22: 212–220. 20 Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med 2013; 188: e13–e64. 21 Polastri M, Nava S, Clini E, et al. COVID-19 and pulmonary rehabilitation: preparing for phase three. Eur Respir J 2020; 55: 2001822. 22 Rimes KA, Chalder T. Treatments for chronic fatigue syndrome. Occup Med (Lond) 2005; 55: 32–39. 23 Torjesen I. NICE cautions against using graded exercise therapy for patients recovering from covid-19. BMJ 2020; 370: m2912. 24 Bardel A, Wallander MA, Wallman T, et al. Age and sex related self-reported symptoms in a general population across 30 years: patterns of reporting and secular trend. PLoS ONE 2019; 14: e0211532. 25 Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ 2020; 369: m1966. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 00542-2020 | - |
dc.identifier.doi | 10.1183/23120541.00542-2020 | - |
dc.identifier.isi | 000603682700109 | - |
dc.identifier.eissn | - | |
local.provider.type | - | |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fullcitation | Goërtz, Yvonne; VAN HERCK, Maarten; Delbressine, Jeannet; Vaes, Anouk; Meys, Roy; Machado, Felipe; Houben-Wilke, Sarah; BURTIN, Chris; Posthuma, Rein; Franssen, Frits; Van Loon, Nicole; Hajian, Bita; Spies, Yvonne; Vijlbrief, Herman; Van't Hul, Alex; Janssen, Daisy & SPRUIT, Martijn A. (2020) Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. In: ERJ open research, 6 (4) (Art N° 00542-2020). | - |
item.contributor | Goërtz, Yvonne | - |
item.contributor | VAN HERCK, Maarten | - |
item.contributor | Delbressine, Jeannet | - |
item.contributor | Vaes, Anouk | - |
item.contributor | Meys, Roy | - |
item.contributor | Machado, Felipe | - |
item.contributor | Houben-Wilke, Sarah | - |
item.contributor | BURTIN, Chris | - |
item.contributor | Posthuma, Rein | - |
item.contributor | Franssen, Frits | - |
item.contributor | Van Loon, Nicole | - |
item.contributor | Hajian, Bita | - |
item.contributor | Spies, Yvonne | - |
item.contributor | Vijlbrief, Herman | - |
item.contributor | Van't Hul, Alex | - |
item.contributor | Janssen, Daisy | - |
item.contributor | SPRUIT, Martijn A. | - |
item.validation | ecoom 2023 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.eissn | 2312-0541 | - |
Appears in Collections: | Research publications |
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Goërtz , Van Herck et al 2020 ERJOR.pdf | Published version | 882.04 kB | Adobe PDF | View/Open |
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